Antibody-Drug Conjugates and Cellular Metabolic Dynamics, Chen

Автор: Wood Clive R
Название: Antibody Drug Discovery
ISBN: 1848166281 ISBN-13(EAN): 9781848166288
Издательство: World Scientific Publishing
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Описание: Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. This title offers guidance to those evaluating and preparing to enter particular areas within the field.

Автор: Pavol Ivanyi
Название: MHC + X
ISBN: 3642740286 ISBN-13(EAN): 9783642740282
Издательство: Springer
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Цена: 13415.00 р.
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Описание: Proceedings of the Workshop-Symposium meeting held in Ommen/ Amsterdam, 7-9 October 1987

Автор: Lo Benny K. C.
Название: Antibody Engineering / Methods and Protocols
ISBN: 1588290921 ISBN-13(EAN): 9781588290922
Издательство: Springer
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Цена: 21343.00 р.
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Описание: A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics.

Автор: Tsumoto
Название: Computer-Aided Antibody Design
ISBN: 1071626086 ISBN-13(EAN): 9781071626085
Издательство: Springer
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Цена: 17074.00 р.
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Описание: This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Автор: Borrebaeck, Carl A. K.
Название: Antibody Engineering
ISBN: 0195091507 ISBN-13(EAN): 9780195091502
Издательство: Oxford Academ
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Описание: This text has been designed to help researchers understand and develop designer antibodies. Its practical approach makes use of state-of-the-art technologies for the production of recombinant human or mouse monoclonal antibodies.

Автор: Laura Caponi; Paola Migliorini
Название: Antibody Usage in the Lab
ISBN: 3662039443 ISBN-13(EAN): 9783662039441
Издательство: Springer
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Цена: 6097.00 р.
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Описание: A handy lab manual that allows quick and easy access to the techniques commonly used in analysing antibody specificity.

Автор: Roland E. Kontermann; Stefan D?bel
Название: Antibody Engineering Volume 2
ISBN: 3642011462 ISBN-13(EAN): 9783642011467
Издательство: Springer
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Цена: 28051.00 р.
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Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.

Автор: Damelin Marc
Название: Innovations for Next-Generation Antibody-Drug Conjugates
ISBN: 3319781537 ISBN-13(EAN): 9783319781532
Издательство: Springer
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Цена: 18294.00 р.
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Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Название: Antibody-drug conjugates
ISBN: 3319376691 ISBN-13(EAN): 9783319376691
Издательство: Springer
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Цена: 14817.00 р.
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Описание: Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg (R)), Brentuximab vedotin (Adcetris (R)), and ado-trastuzumab emtansine (Kadcyla (R)), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011).

Автор: Van Delft Floris, Lambert John M.
Название: Chemical Linkers in Antibody-Drug Conjugates (Adcs)
ISBN: 1839162635 ISBN-13(EAN): 9781839162633
Издательство: Royal Society of Chemistry
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Описание: Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.

Автор: Gail Lewis Phillips
Название: Antibody-Drug Conjugates and Immunotoxins
ISBN: 1489997008 ISBN-13(EAN): 9781489997005
Издательство: Springer
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Цена: 19376.00 р.
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Описание: This volume collets leading research on antibody-drug conjugates and immunotoxins. It examines all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Автор: Marc Damelin
Название: Innovations for Next-Generation Antibody-Drug Conjugates
ISBN: 3030086275 ISBN-13(EAN): 9783030086275
Издательство: Springer
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Цена: 18294.00 р.
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Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.