Автор: Wood Clive R Название: Antibody Drug Discovery ISBN: 1848166281 ISBN-13(EAN): 9781848166288 Издательство: World Scientific Publishing Рейтинг: Цена: 24552.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. This title offers guidance to those evaluating and preparing to enter particular areas within the field.
Название: New antibody formats ISBN: 0323994024 ISBN-13(EAN): 9780323994026 Издательство: Elsevier Science Рейтинг: Цена: 27791.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 145 miles of lush, ever-green walking in North East Wales: featuring fourteen routes within the Clwydian Range and Dee Valley Area of Outstanding Natural Beauty, embracing the Clwydian and Berwyn Hills and Llantysilio Mountain; three walks on the North Wales coast between Great Orme and Point of Ayr; eleven rambles to the east of the River Conwy.
Автор: Benny K. C. Lo Название: Antibody Engineering ISBN: 1617373524 ISBN-13(EAN): 9781617373527 Издательство: Springer Рейтинг: Цена: 21343.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite this setback, advances in recombinant DNA techniques over the last 15-20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA.
Автор: Roland E. Kontermann; Stefan D?bel Название: Antibody Engineering Volume 2 ISBN: 3642422764 ISBN-13(EAN): 9783642422768 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319468758 ISBN-13(EAN): 9783319468754 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Автор: McCafferty, John; Hoogenboom, Hennie; Chiswell, Da Название: Antibody Engineering A Practical Approach (Hardback) ISBN: 0199635927 ISBN-13(EAN): 9780199635924 Издательство: Oxford Academ Рейтинг: Цена: 16450.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recombinant DNA techniques have revolutionized the isolation and production of antibodies in recent years, and rapid changes have been made. The time is now ripe to assemble in a Practical Approach volume the protocols which allow the researcher to isolate a new antibody, analyse its properties, format the right antibody molecule or fragment, and produce it in usable quantitites.
Автор: Damien Nevoltris; Patrick Chames Название: Antibody Engineering ISBN: 1493993534 ISBN-13(EAN): 9781493993536 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Нет в наличии.
Описание: This detailed new edition provides complete and easy access to a variety of antibody engineering techniques. The volume explores topics such as the generation of native, synthetic, or immune antibody libraries, the selection of lead candidates via the different powerful and innovative display technologies, Fc engineering, as well as their production, characterization, and optimization of antibodies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Antibody Engineering: Methods and Protocols, Third Edition presents the reader with an extensive toolbox to create the powerful molecules of tomorrow.
Автор: L. Nathan Tumey Название: Antibody-Drug Conjugates ISBN: 1493999311 ISBN-13(EAN): 9781493999316 Издательство: Springer Рейтинг: Цена: 14025.00 р. Наличие на складе: Нет в наличии.
Описание: This volume looks at key methodologies that are commonly used across antibody drug conjugates (ADCs) programs.
Автор: William C. Davis Название: Monoclonal Antibody Protocols ISBN: 0896033082 ISBN-13(EAN): 9780896033085 Издательство: Springer Рейтинг: Цена: 14635.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since the initial description of techniques to immortalize anti- body-producing B-lymphocytes by fusion with tissue culture-adapted myeloma cells, methods have been developed to produce monoclonal antibodies of defined specificity in multiple animal species.
Автор: Liddell, Eryl Название: Antibody Technology ISBN: 1872748872 ISBN-13(EAN): 9781872748870 Издательство: Taylor&Francis Рейтинг: Цена: 10104.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Название: Antibody-drug conjugates ISBN: 3319376691 ISBN-13(EAN): 9783319376691 Издательство: Springer Рейтинг: Цена: 14817.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg (R)), Brentuximab vedotin (Adcetris (R)), and ado-trastuzumab emtansine (Kadcyla (R)), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011).
Автор: Lo Benny K. C. Название: Antibody Engineering / Methods and Protocols ISBN: 1588290921 ISBN-13(EAN): 9781588290922 Издательство: Springer Рейтинг: Цена: 21343.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics.
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