Chemical Linkers in Antibody-Drug Conjugates (Adcs), Van Delft Floris, Lambert John M.

Автор: Ulf Grawunder; Stefan Barth
Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
ISBN: 3319836099 ISBN-13(EAN): 9783319836096
Издательство: Springer
Рейтинг:
Цена: 18294.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Автор: Ulf Grawunder; Stefan Barth
Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
ISBN: 3319468758 ISBN-13(EAN): 9783319468754
Издательство: Springer
Рейтинг:
Цена: 18294.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Название: Antibody-drug conjugates
ISBN: 3319376691 ISBN-13(EAN): 9783319376691
Издательство: Springer
Рейтинг:
Цена: 14817.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg (R)), Brentuximab vedotin (Adcetris (R)), and ado-trastuzumab emtansine (Kadcyla (R)), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011).

Автор: Ducry
Название: Antibody-Drug Conjugates
ISBN: 1627035400 ISBN-13(EAN): 9781627035408
Издательство: Springer
Рейтинг:
Цена: 20733.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.

Автор: Marc Damelin
Название: Innovations for Next-Generation Antibody-Drug Conjugates
ISBN: 3030086275 ISBN-13(EAN): 9783030086275
Издательство: Springer
Рейтинг:
Цена: 18294.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Автор: Laurent Ducry
Название: Antibody-Drug Conjugates
ISBN: 1493960261 ISBN-13(EAN): 9781493960262
Издательство: Springer
Рейтинг:
Цена: 14635.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.

Автор: Gail Lewis Phillips
Название: Antibody-Drug Conjugates and Immunotoxins
ISBN: 1489997008 ISBN-13(EAN): 9781489997005
Издательство: Springer
Рейтинг:
Цена: 19376.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume collets leading research on antibody-drug conjugates and immunotoxins. It examines all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Автор: Damelin Marc
Название: Innovations for Next-Generation Antibody-Drug Conjugates
ISBN: 3319781537 ISBN-13(EAN): 9783319781532
Издательство: Springer
Рейтинг:
Цена: 18294.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Название: Polymer-protein conjugates
ISBN: 0444640819 ISBN-13(EAN): 9780444640819
Издательство: Elsevier Science
Рейтинг:
Цена: 26107.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Polymer-Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched.

Автор: Helmut Schlaad
Название: Bio-synthetic Polymer Conjugates
ISBN: 3642445071 ISBN-13(EAN): 9783642445071
Издательство: Springer
Рейтинг:
Цена: 25075.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Bjorn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M.