This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Patil Popat M Название: Discoveries In Pharmacological Sciences ISBN: 9814355070 ISBN-13(EAN): 9789814355070 Издательство: World Scientific Publishing Рейтинг: Цена: 27720.00 р. 39600.00-30% Наличие на складе: Есть (1 шт.) Описание: Throughout history, the perpetuation of species, the need for survival, and human curiosity, intelligence and skills provided the basis for the development of drug science. This title contains the history of herbal medicine as it emerged about 5,000 years ago.
Автор: Laurence Brunton, Bruce Chabner Название: Goodman And Gilman`s Pharmacological Basis Of Therapeutics 12 ed ISBN: 0071624422 ISBN-13(EAN): 9780071624428 Издательство: McGraw-Hill Рейтинг: Цена: 17503.00 р. 25004.00-30% Наличие на складе: Есть (1 шт.) Описание: A medical text that represents accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. It helps thousands of practitioners and students to an understanding of the drugs essential to preventing, diagnosing, and treating disease.
Автор: W. Holmes Название: Pharmacological Control of Lipid Metabolism ISBN: 1468475495 ISBN-13(EAN): 9781468475494 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Each meeting has introduced or developed some new concepts in the areas of lipid metabolism and drugs. Principal among the many new concepts discussed were lipoprotein synthesis and metabolism, apoprotein structure and function, whole body metabolism of cholesterol, and aspects of myocardial and aortic metabolism.
Название: Drugs, Ageing and Society ISBN: 1032687770 ISBN-13(EAN): 9781032687773 Издательство: Taylor&Francis Рейтинг: Цена: 15004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the mostfrequently- prescribed drugs in the Western world. During the past decade a large number of new compounds were marketed, some of which had to be withdrawn after a short while because of adverse drug reactions. These experiences led to an under- standing that a complete picture of the safety of these drugs can only be obtained after their introduction into the marketplace.
Differentmethods ofpost-marketing surveillance (PMS) serve as important tools for monitoring the frequency of adverse reactions and for generating and corroborating hypotheses. Experience with PMS has thusfar been quite limited in Germany. In 1987 a non-profit organization, "Verein zur Langzeituntersuchung von Arzneimittel- wirkungen auf dem Gebiet der Rheumatologie e.
V. " (VLAR) was founded by interested physicians and pharmacologists to raise funds and perform investiga- tions on the safety of NSAIDs. The first project by the VLAR, SPALA ("Safety Profile of Antirheumatics in Long-Term Administration"), was sponsored by F.
Hoffmann-La Roche AG (Basel, Switzerland). In July 1990, when the project was successfully terminated, almost 30,000 patients had been completely docu- mented and their medical records entered into a computer for subsequent review by a select panel of experts with experience in monitoring adverse reactions to NSAIDs. The comments, criticisms, and ideas of these experts were brought togetherat a symposium organized by the VLAR at the Klinikum Steglitz (Berlin, Germany) on 12 October 1990.
Название: Pharmacological guide to paroxetine ISBN: 1536180459 ISBN-13(EAN): 9781536180459 Издательство: Nova Science Рейтинг: Цена: 27402.00 р. Наличие на складе: Невозможна поставка.
Описание: This is a comprehensive reference manual. Its authors include seasoned practicing mental health professionals and doctoral psychology program faculty with over a century of combined clinical experience. The book provides a history of paroxetines development, licensing, and application to a growing variety of diagnoses, including social anxiety disorder, generalized anxiety disorder, panic attacks, post-traumatic stress disorder, premenstrual dysphoric disorder, perimenopausal hot flashes, and obsessive-compulsive disorder. Paroxetines unlabeled uses are also discussed, including impulse control disorders, eating disorders, vasomotor symptoms of menopause, obsessive-compulsive disorder in children, mild dementia-associated agitation in nonpsychotic individuals, treatment of premature ejaculation and diabetic neuropathy. The pharmacology of paroxetine is explored in detail, with attention to its chemical and physical properties, absorption, metabolism, mechanism of action, interactions with enzymes, genes, proteins, and other medications, anticholinergic effects, potential adverse effects, and counter-indications for use. Paroxetines nonlinear pharmacokinetics are explained and discussed with application to specific populations and potential drug interactions. Special attention is given to considerations in the use of paroxetine with pediatric populations and older adults. There is detailed exploration of the use of human biological specimens to determine concentrations of paroxetine in bioanalytical applications, including forensic settings. Paroxetines potential for novel future applications is discussed, including improving cardiac function following myocardial infarction, and the treatment of allodynia, colorectal cancer, Alzheimers Disease, and Parkinsons Disease.
Автор: Krauss Brendon Название: Handbook of Pharmacological Sciences: Volume I ISBN: 1632422123 ISBN-13(EAN): 9781632422125 Издательство: Неизвестно Цена: 24783.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Claudio A. Naranjo; Edward M. Sellers Название: Novel Pharmacological Interventions for Alcoholism ISBN: 1461277051 ISBN-13(EAN): 9781461277057 Издательство: Springer Рейтинг: Цена: 12805.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Novel Pharmacological Interventions for Alcoholism identifies priorities for focusing alcoholism and addiction research efforts during the coming years. A number of important issues concerning methodology, mechanisms, clinical evaluation, and pharmaceutical aspects are discussed.
Автор: A.F. Casy Название: The Steric Factor in Medicinal Chemistry ISBN: 0306442892 ISBN-13(EAN): 9780306442896 Издательство: Springer Рейтинг: Цена: 36468.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Providing an overview of medicinal stereochemistry, this book is suitable for graduate students and research workers in medicinal chemistry and pharmacology.
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