Описание: Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. This book summarizes the status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments.
Автор: Hughes Название: Translational Toxicology ISBN: 3319801430 ISBN-13(EAN): 9783319801438 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Нет в наличии.
Описание: Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
Автор: Wehling, Martin Название: Principles Of Translational Science In Medicine ISBN: 0128204931 ISBN-13(EAN): 9780128204931 Издательство: Elsevier Science Рейтинг: Цена: 21054.00 р. Наличие на складе: Нет в наличии.
Описание: Collins CSEC (R) Human and Social Biology provides a new approach to the study of the CSEC (R) HSB syllabus that focuses on the skills of recalling facts, applying facts and analysing data as needed for the examination and School Based Assessment. It provides the content and skills that students truly need to master to pass - and do well in - the exam.
Автор: Mohammad A. Tabrizi; Gadi G. Bornstein; Scott L. K Название: Development of Antibody-Based Therapeutics ISBN: 9811344329 ISBN-13(EAN): 9789811344329 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Нет в наличии.
Описание: The biologics market continues to witness an impressive rate of growth and the monoclonal antibody market, in particular, has contributed remarkably to the expansion of this segment within the pharmaceutical industry. In 2006, close to 80% of the annual biologics growth rate in the United States (US) was attributed to cancer and anti-TNF antibodies, with increases in growth of 56% and 25%, respectively, compared to those in the previous year. Additionally, the monoclonal antibody sector is anticipated to achieve a growth rate of approximately 14% by 2012, easily outstripping the predicted 0.6% growth rate in the small molecules market. The robust late-stage antibody pipeline within the biotech sector has drawn an increasing amount of interest from the large pharmaceutical industry and has triggered the largest product and platform deals in 2006, with values more than $2.1 and $5.1 billion in partnering and mergers and acquisitions, respectively. Additionally, with the forthcoming emergence of biogenerics, next-generation bio-improved antibodies have drawn much attention and increasingly contribute to the growth of the biologics segment. As next-generation monoclonal antibodies confront their first-generation rivals, it is critical that these next-generation products offer a clear differentiating advantage against the existing competition. Successful strategies for the development of monoclonal antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, pharmacokinetic and pharmacodynamic (PK/PD) properties, antibody cross-reactivity across species, market differentiation opportunities for the first- and next-generation leads, and regulatory requirements from the early stages of antibody development. Biophysical measurements are one of the critical components necessary for the design of effective translational strategies for lead selection and evaluation of relevant animal species for preclinical safety and efficacy studies. Incorporation of effective translational strategies from the early stages of the antibody development process is a necessity, and when considered, it not only reduces development time and cost, but also fosters implementation of rational decision-making throughout all phases of antibody development. Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the 'unit dose' and 'unit effect' with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective and novel next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of bio-improved antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.
Автор: Rahman, Shafiqur Название: The Brain As A Drug Target,98 ISBN: 0123855063 ISBN-13(EAN): 9780123855060 Издательство: Elsevier Science Рейтинг: Цена: 21054.00 р. Наличие на складе: Нет в наличии.
Описание: The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This title discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. It discusses discoveries, approaches, and ideas.
Автор: Robbins Trevor W., Sahakian Barbara J. Название: Translational Neuropsychopharmacology ISBN: 3319816306 ISBN-13(EAN): 9783319816302 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
Описание: This book reviews techniques for assessing insulin action, insulin secretion and body composition, with reference to new drugs, in phase 1 & 2 studies. Adds to understanding of drug effects and non-drug treatment strategies in obesity and type 2 diabetes.
Описание: The concept of cancer stem cells has great clinical implications. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis.
Автор: Nikhil C. Munshi; Kenneth C. Anderson Название: Advances in Biology and Therapy of Multiple Myeloma ISBN: 1489989145 ISBN-13(EAN): 9781489989147 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Автор: Mohammad A. Tabrizi; Gadi G. Bornstein; Scott L. K Название: Development of Antibody-Based Therapeutics ISBN: 1489991131 ISBN-13(EAN): 9781489991133 Издательство: Springer Рейтинг: Цена: 18237.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the `unit dose` and `unit effect` with respect to beneficial and deleterious effects.
Описание: The concept of cancer stem cells has great clinical implications. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis.
Автор: Littman Название: Translational Medicine and Drug Discovery ISBN: 0521886457 ISBN-13(EAN): 9780521886451 Издательство: Cambridge Academ Рейтинг: Цена: 13781.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. It is essential for anyone interested in translational medicine from a variety of backgrounds: university institutes, medical schools, pharmaceutical companies and drug development researchers and decision-makers.
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