Автор: Ilmoniemi Risto, Sarvas Jukka Название: Brain Signals: Physics and Mathematics of Meg and Eeg ISBN: 0262039826 ISBN-13(EAN): 9780262039826 Издательство: Random House (USA) Рейтинг: Цена: 8966.00 р. Наличие на складе: Нет в наличии.
Описание: A unified treatment of the generation and analysis of brain-generated electromagnetic fields.
Автор: H?l?ne Girouard Название: Hypertension and the Brain as an End-Organ Target ISBN: 3319256149 ISBN-13(EAN): 9783319256146 Издательство: Springer Рейтинг: Цена: 17097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first comprehensive overview of the effects of hypertension on the brain. The book discusses not only the relationship between hypertension and stroke, but also the much less studied relationship between hypertension and cognitive decline and neurodegenerative diseases such as Alzheimer`s.
Автор: Girouard Hйlиne Название: Hypertension and the Brain as an End-Organ Target ISBN: 3319798154 ISBN-13(EAN): 9783319798158 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Нет в наличии.
Описание: The first comprehensive overview of the effects of hypertension on the brain. The book discusses not only the relationship between hypertension and stroke, but also the much less studied relationship between hypertension and cognitive decline and neurodegenerative diseases such as Alzheimer's. It seeks to answer two important questions. First, what are the conditions under which hypertension is associated with stroke, cognitive decline, and neurodegenerative disease? And second, what are the biological mechanisms by which hypertension alters brain homeostasis? By looking at the biological mechanisms of these relationships, this book provides insight to neuroscientists and neurologists regarding why anti-hypertension treatments make a big difference in the case of stroke, but have very little impact on cognitive decline and brain aging.
Автор: Mark von Itzstein Название: Influenza Virus Sialidase - A Drug Discovery Target ISBN: 3034807791 ISBN-13(EAN): 9783034807791 Издательство: Springer Рейтинг: Цена: 22796.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented.
Автор: Jurgen Moll; Riccardo Colombo Название: Target Identification and Validation in Drug Discovery ISBN: 1493962787 ISBN-13(EAN): 9781493962785 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate. In Target Identification and Validation in Drug Discovery: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to identify and validate new target. These include methods and approaches covering biochemical, cell based, in vivo models and translational methods. Chapters also include selected case reports that demonstrate the integration of these technologies to real life experiences and to demonstrate the multiple use of more than one technology to increase knowledge on a specific target. These Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Target Identification and Validation in Drug Discovery: Methods and Protocols contains a comprehensive list of essential methods and clear protocols to follow.
Описание: This detailed book showcases recent advances in computational design of multi-target drug candidates involving various ligand and structure-based strategies.
Автор: J?rgen Moll; Sebastian Carotta Название: Target Identification and Validation in Drug Discovery ISBN: 1493991442 ISBN-13(EAN): 9781493991440 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Fully updated and authoritative, Target Identification and Validation in Drug Discovery: Methods and Protocols, Second Edition is an ideal guide for molecular and cellular biologists, pharmacologists, pathologists, bioinformaticians, clinical researchers, or investigators, as well as experts in other fields that need a quick overview of these state-of-the-art technologies.
Автор: Scotti Название: Drug Target Selection and Validation ISBN: 3030958949 ISBN-13(EAN): 9783030958947 Издательство: Springer Рейтинг: Цена: 17074.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation.
Автор: Jurgen Moll; Riccardo Colombo Название: Target Identification and Validation in Drug Discovery ISBN: 1627033106 ISBN-13(EAN): 9781627033107 Издательство: Springer Рейтинг: Цена: 13415.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports.
Описание: Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant and most challenging areas of drug discovery.
Описание: A book useful to postgraduate students and researchers in medicinal chemistry and pharmacology, as well as specialists in the acute brain injury field.
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