This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials.
In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered.
The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.
Combinational optimization (CO) is a topic in applied mathematics, decision science and computer science that consists of finding the best solution from a non-exhaustive search. CO is related to disciplines such as computational complexity theory and algorithm theory, and has important applications in fields such as operations research/management science, artificial intelligence, machine learning, and software engineering.
Advances in Combinatorial Optimization presents a generalized framework for formulating hard combinatorial optimization problems (COPs) as polynomial sized linear programs. Though developed based on the 'traveling salesman problem' (TSP), the framework allows for the formulating of many of the well-known NP-Complete COPs directly (without the need to reduce them to other COPs) as linear programs, and demonstrates the same for three other problems (e.g. the 'vertex coloring problem' (VCP)). This work also represents a proof of the equality of the complexity classes "P" (polynomial time) and "NP" (nondeterministic polynomial time), and makes a contribution to the theory and application of 'extended formulations' (EFs).
On a whole, Advances in Combinatorial Optimization offers new modeling and solution perspectives which will be useful to professionals, graduate students and researchers who are either involved in routing, scheduling and sequencing decision-making in particular, or in dealing with the theory of computing in general.
Автор: Daniel Bar-Shalom; Klaus Rose Название: Pediatric Formulations ISBN: 1493945211 ISBN-13(EAN): 9781493945214 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.
Автор: Ellis Название: Economic Model Predictive Control ISBN: 3319411071 ISBN-13(EAN): 9783319411071 Издательство: Springer Рейтинг: Цена: 17074.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents general methods for the design of economic model predictive control (EMPC) systems for broad classes of nonlinear systems that address key theoretical and practical considerations including recursive feasibility, closed-loop stability, closed-loop performance, and computational efficiency. Specifically, the book proposes:Lyapunov-based EMPC methods for nonlinear systems; two-tier EMPC architectures that are highly computationally efficient; and EMPC schemes handling explicitly uncertainty, time-varying cost functions, time-delays and multiple-time-scale dynamics.The proposed methods employ a variety of tools ranging from nonlinear systems analysis, through Lyapunov-based control techniques to nonlinear dynamic optimization. The applicability and performance of the proposed methods are demonstrated through a number of chemical process examples.The book presents state-of-the-art methods for the design of economic model predictive control systems for chemical processes.In addition to being mathematically rigorous, these methods accommodate key practical issues, for example, direct optimization of process economics, time-varying economic cost functions and computational efficiency. Numerous comments and remarks providing fundamental understanding of the merging of process economics and feedback control into a single framework are included. A control engineer can easily tailor the many detailed examples of industrial relevance given within the text to a specific application.The authors present a rich collection of new research topics and references to significant recent work making Economic Model Predictive Control an important source of information and inspiration for academics and graduate students researching the area and for process engineers interested in applying its ideas.
Автор: Aruqaj, Bujar (Freie Universitat Berlin, Germany) Название: Natural Products and Nano-Formulations in Cancer Chemoprevention ISBN: 103231303X ISBN-13(EAN): 9781032313030 Издательство: Taylor&Francis Рейтинг: Цена: 26030.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers various aspects of cancer chemoprevention including overview of chemoprevention in the process of tumorigenesis, and role of various phytochemicals, functional foods, and dietary interventions in disease prevention, and techniques such as cancer stem cell targeting, nano-formulations, and so forth.
Название: Photostability of Drugs and Drug Formulations ISBN: 0367394103 ISBN-13(EAN): 9780367394103 Издательство: Taylor&Francis Рейтинг: Цена: 10411.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource.
The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results. Features
Assists non-experts in this field design a test protocol and interpret the results
Covers in vitro and in vivo aspects of interactions between drugs and light
Explores the kinetic and chemical aspects of drug photodecomposition
Discusses the problems frequently encountered in photochemical stability testing
Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs
Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint
Offers specific guidance in photos
Автор: Moore Mark A. Название: Early Creedal Formulations and Theological Discourse ISBN: 0578783959 ISBN-13(EAN): 9780578783956 Издательство: Неизвестно Рейтинг: Цена: 1240.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Theology is a grand conversation, comprised of a myriad of voices and viewpoints. A great temptation exists within theology today, however, which could signal the loss of a unique Christian identity. The creedal formulations of the early church were never meant to serve as shackles constricting further theological exploration. They were, and still are, relevant guides in assessing the crowded conversation of theology. Early creedal formulations identified and articulated primary affirmations of the biblical narrative not to put an end to the conversation but rather to focus the conversation on the unique Christian identity of God as presented in Scripture. This book examines the function of early creedal formulations as essential identity markers in theological discourse with the goal of constructing an approach to the various subcategories of systematic theology that mirrors the creedal process. This approach, termed here as "Essential Identity Markers" (or simply EIM), seeks to identify and articulate the essential identity markers of a given theological subcategory, in order to define the proper parameters for theological discourse while still allowing such discourse to develop and expand within the articulated identity markers. The EIM model constructed and proposed in this book offers an approach to theology that mirrors the creedal process and seeks to guide modern theological conversations as the community of faith continues to explore the space framed by these markers.
Автор: Paulo Flores Название: Concepts and Formulations for Spatial Multibody Dynamics ISBN: 331916189X ISBN-13(EAN): 9783319161891 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book will be particularly useful to those interested in multibody simulation (MBS) and the formulation for the dynamics of spatial multibody systems.
Автор: John F. Carpenter; Mark C. Manning Название: Rational Design of Stable Protein Formulations ISBN: 1461351316 ISBN-13(EAN): 9781461351313 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
