Daniel Bar-Shalom; Klaus Rose Pediatric Formulations 9781493945214

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Автор: Daniel Bar-Shalom; Klaus Rose
Название: Pediatric Formulations
ISBN: 9781493945214
Издательство: Springer
Классификация:

Педиатрия

Аптечная служба и отпуск лекарственных средств

Промышленная химия

Технологии производства фармацевтических препаратов

ISBN-10: 1493945211
Обложка/Формат: Paperback
Страницы: 439
Вес: 0.63 кг.
Дата издания: 23.08.2016
Серия: AAPS Advances in the Pharmaceutical Sciences Series
Язык: English
Издание: Softcover reprint of
Иллюстрации: 28 tables, black and white; 36 illustrations, color; 40 illustrations, black and white; xv, 439 p. 76 illus., 36 illus. in color.
Размер: 234 x 156 x 23
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Подзаголовок: A Roadmap
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.
Дополнительное описание: Pediatric Development: Anatomy.- Age, Weight, Body Surface and Stature, Organ Development.- Pediatric Development: Physiology. Enzymes, Drug Metabolism, Pharmacokinetics and Pharmacodynamics.- Pediatric Development – Gastrointestinal.- How to Estimate the

Pediatric Formulations, Daniel Bar-Shalom; Klaus Rose