Chromatin And Gene Function: A Primer, John C Lucchesi

Автор: John C Lucchesi
Название: Chromatin And Gene Function: A Primer
ISBN: 9811258937 ISBN-13(EAN): 9789811258930
Издательство: World Scientific Publishing
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Цена: 7128.00 р.
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Описание: The purpose of this primer is to provide students, teachers as well as academic and industry researchers with a succinct account of the chemical and structural features of chromatin and the role that these features play in the maintenance and function of the genetic material.It is universally accepted that DNA is the carrier of the genetic information that is transmitted from parents to their offspring and that it is responsible for the anatomy, physiology and behavior of all individuals throughout development and adult life. Yet, how this information is retrieved and used selectively to allow a fertilized egg to become an organism made up of myriads of different cells and tissues is not as evident and easily understood.Dr Lucchesi, an internationally known researcher and teacher, provides an easily opened window into the role that the complex of proteins and nucleic acids that are associated with the DNA play in mediating gene expression and in responding to environmental circumstances.

Автор: Brehon Laurent
Название: Chromatin Dynamics in Cellular Function
ISBN: 3642070248 ISBN-13(EAN): 9783642070242
Издательство: Springer
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Цена: 15855.00 р.
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Описание: This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.

Автор: W. Nagl; V. Hemleben; F. Ehrendorfer
Название: Genome and Chromatin: Organization, Evolution, Function
ISBN: 3709185580 ISBN-13(EAN): 9783709185582
Издательство: Springer
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Цена: 10610.00 р.
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Описание: Orientation about actual trends and results in our understanding of the organization, evolution, and function of the plant genome at the level of the DNA (gene), the level of chromatin, and the level of the karyotype.

Автор: Claudio Nicolini
Название: Chromatin Structure and Function
ISBN: 1468409751 ISBN-13(EAN): 9781468409758
Издательство: Springer
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Цена: 6097.00 р.
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Автор: Claudio Nicolini
Название: Chromatin Structure and Function
ISBN: 1468409786 ISBN-13(EAN): 9781468409789
Издательство: Springer
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Цена: 14818.00 р.
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Описание: A few chapters, dealing at the level of intact cell and/or in classical genetic terms, with aging, differentiation and neoplastic transformation, have been included to furnish a more comprehensive view of fundamental cell functions directly and indirectly related to the structure and function of the genetic apparatus.

Автор: Vincenzo Pirrotta
Название: Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms
ISBN: 9811258902 ISBN-13(EAN): 9789811258909
Издательство: World Scientific Publishing
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Описание: This book is an introduction to epigenetics, a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Starting with the discovery of repressor proteins in the 1960s, epigenetics evolved into a kind of user manual for the genetic information, telling the genome if, when, how much and in what cells to read genes. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences and an understanding of its basic principles is therefore essential for every student in this field.The field of chromatin and epigenetics has developed very rapidly in the past 15-20 years. The pace in the field of epigenetics has now slowed down, the basic outlines of the mechanisms and implications have solidified and a consensus has been achieved among the researchers in the field. At the same time, these mechanisms and implications are now an integral part of how we think about the genome. Genes are more than just DNA and more than just protein-coding sequences and this realization has revolutionized our understanding of the genome, gene expression and its regulation in development, health and disease. It is time, therefore, for a textbook to help train a new generation of biologists and health scientists as well as providing a basic competence among practitioners in allied fields. The present book has grown out of a course given for the past 13 years to advanced undergraduates at Rutgers University. In keeping with the experience in that course, the book is abundantly illustrated, presents a wealth of specific examples, and includes a chapter describing a number of methods and techniques that have driven the advances in the field.

Автор: Blossey, Ralf
Название: Chromatin
ISBN: 1032241977 ISBN-13(EAN): 9781032241975
Издательство: Taylor&Francis
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Цена: 7808.00 р.
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Автор: Binda, Olivier
Название: Chromatin Signaling and Diseases
ISBN: 0128023899 ISBN-13(EAN): 9780128023891
Издательство: Elsevier Science
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Цена: 17517.00 р.
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Описание: "

Chromatin Signaling" "and Diseases" covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.

After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.

Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in "Chromatin Signaling and Diseases." Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.
Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with agingEducates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathologyExplores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signalingHelps researchers learn about the quickly expanding field of chromatin signaling

Автор: Zini
Название: Sperm Chromatin for the Clinician
ISBN: 1461478421 ISBN-13(EAN): 9781461478423
Издательство: Springer
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Цена: 10610.00 р.
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Описание: This condensed version of Zini and Agarwal`s Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction offers select, clinical chapters for a handy, resource about this cutting-edge topic in reproductive medicine.

Автор: Zini
Название: Sperm Chromatin for the Researcher
ISBN: 1461484588 ISBN-13(EAN): 9781461484585
Издательство: Springer
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Цена: 10610.00 р.
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Описание: Sperm Chromatin for the Researcher

Автор: Gardner George
Название: Animal Genetics: Epigenetics and Chromatin
ISBN: 168286782X ISBN-13(EAN): 9781682867822
Издательство: Неизвестно
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Цена: 24460.00 р.
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Автор: Tsanev, Roumen G.
Название: Replication and Transcription of Chromatin
ISBN: 0849368030 ISBN-13(EAN): 9780849368035
Издательство: Taylor&Francis
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Цена: 59717.00 р.
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