Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms, Vincenzo Pirrotta
Автор: Vincenzo Pirrotta Название: Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms ISBN: 9811257620 ISBN-13(EAN): 9789811257629 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is an introduction to epigenetics, a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Starting with the discovery of repressor proteins in the 1960s, epigenetics evolved into a kind of user manual for the genetic information, telling the genome if, when, how much and in what cells to read genes. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences and an understanding of its basic principles is therefore essential for every student in this field.The field of chromatin and epigenetics has developed very rapidly in the past 15-20 years. The pace in the field of epigenetics has now slowed down, the basic outlines of the mechanisms and implications have solidified and a consensus has been achieved among the researchers in the field. At the same time, these mechanisms and implications are now an integral part of how we think about the genome. Genes are more than just DNA and more than just protein-coding sequences and this realization has revolutionized our understanding of the genome, gene expression and its regulation in development, health and disease. It is time, therefore, for a textbook to help train a new generation of biologists and health scientists as well as providing a basic competence among practitioners in allied fields. The present book has grown out of a course given for the past 13 years to advanced undergraduates at Rutgers University. In keeping with the experience in that course, the book is abundantly illustrated, presents a wealth of specific examples, and includes a chapter describing a number of methods and techniques that have driven the advances in the field.
Описание: During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes.
Автор: Saldanha, Sabita Название: Epigenetic Mechanisms in Cancer ISBN: 0128095520 ISBN-13(EAN): 9780128095522 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Нет в наличии.
Описание: Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offer a unique evaluation of signature differences in of childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.
Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc.
Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management
Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis
Features contributions by leading experts in the field
Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs
Описание: Advances from Computational and Experimental Studies of Chromatin Structure and Epigenetics Mechanisms, Volume 122, the latest release in the Enzymes - Mechanisms, Dynamics and Inhibition series, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors.
Автор: Naumova Anna K & Taketo-Hosotani Teruko Название: Epigenetics In Human Reproduction And Development ISBN: 9813144262 ISBN-13(EAN): 9789813144262 Издательство: World Scientific Publishing Цена: 18216.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood.
Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.
Автор: Lucchesi John Название: Epigenetics, Nuclear Organization & Gene Function ISBN: 0198831218 ISBN-13(EAN): 9780198831211 Издательство: Oxford Academ Рейтинг: Цена: 9198.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a framework to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. It further aims to highlight the role of the three-dimensional organization of the genetic material itself and its distribution in a functionally compartmentalized nucleus.
Автор: Steven Gray Название: Epigenetic Cancer Therapy ISBN: 0128002069 ISBN-13(EAN): 9780128002063 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Нет в наличии.
Описание:
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.
The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).
The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.
Название: Epigenetic cancer therapy ISBN: 0323913679 ISBN-13(EAN): 9780323913676 Издательство: Elsevier Science Рейтинг: Цена: 23917.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past few decades, chromatin modulation has emerged as an important regulator of gene expression. This second edition provides detailed information on the epigenetic mechanisms in plants, illustrating the value of this research in plants of agronomic importance. It examines recent advances regarding plants’ epigenetic regulation in response to abiotic and biotic types of stress; the epigenetic basis of plant immunity; evolution and functions of plant histones; epigenetic variation and plant breeding; and epigenome editing and crop improvement. The content is intended to promote the development of future biotechnologies to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases, and to increase crop productivity. The development of new fields, like epigenome editing and RNA epigenetics, will certainly improve our understanding of currently known epigenetic modifications and their roles in e.g. host-pathogen interactions, crop productivity, and in response to environmental stimuli. This volume contains twelve new/revised chapters, written by an international team of experts on plant epigenetics, and addresses the needs of researchers and professionals in the fields of agronomics, crop breeding, epigenetics, plant biochemistry, plant developmental biology, and related disciplines.
Автор: Philippe Jeanteur Название: Epigenetics and Chromatin ISBN: 3540852360 ISBN-13(EAN): 9783540852360 Издательство: Springer Рейтинг: Цена: 13677.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Emphasizes on the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. This work deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.
Автор: Gardner George Название: Animal Genetics: Epigenetics and Chromatin ISBN: 168286782X ISBN-13(EAN): 9781682867822 Издательство: Неизвестно Рейтинг: Цена: 24460.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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