Описание: Why the Spike protein is relevant for COVID19 therapeutics
Whole genome mutation rates
Phylogenetic systems
Mechanism of immune escape: single nucleotide mutations, insertion/deletions, and recombination. Spike protein mutations detected in currently circulating strains.
SARS-CoV-2 variants
B.1.1.298
B.1.1.7 (alpha)
B.1.351 (beta)
B.1.1.28- and B.1.1.33-derived Brazilian variants (including gamma and zeta)
B.1.525 (eta)
B.1.526 (iota)
B.1.427/B.1.429 (epsilon)
B.1.617-derived variants (including kappa and delta)
B.1.617.1
Delta VOC
C.37 (lambda)
P.3 (theta)
Other variants under monitoring (VUM)
Which strain will finally become dominant?
SARS-CoV-2 variants characterization
Predicting the functional consequences of mutations
Efficacy of vaccines and monoclonal antibodies against SARS-CoV-2 variants
Selective pressures exerted by antibody-based therapeutics
Описание: This book offers an analytical look at the much debated risks and benefits of the newly developed COVID-19 mRNA-vaccines. As such, it is one of the first books to give a comprehensive overview of mRNA vaccines against COVID-19 and the only one that addresses this topic from a broad multidisciplinary background. It brings together insights from various underlying disciplines on the challenges of developing and evaluating the most suitable vaccines for mass vaccination programs enrolled throughout the world - focusing on safety and efficacy. This book should not be missing on the shelf of any biomedical researcher, epidemiologist, public health professional or clinical researcher interested in SARS-CoV2 or virology and vaccine development in general.
Автор: Chu Название: SARS-CoV-2 ISBN: 1071621130 ISBN-13(EAN): 9781071621134 Издательство: Springer Рейтинг: Цена: 18904.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume provides the increasing number of SARS-CoV-2 researchers with a useful handbook covering multidisciplinary approaches on various aspects of SARS-CoV-2 research, brought together by leading laboratories across the globe. Topics covered include techniques in clinical and diagnostic virology, basic protocols in cell and virus culture, as well as bioinformatics and proteomics approaches in cellular response studies. This comprehensive collection also covers methods in immunology, animal models, antivirals and vaccine development strategies, as well as biorisk and mitigation measurements for SARS-CoV-2 research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that is vital for success in the lab. Practical and timely, SARS-CoV-2: Methods and Protocols serves as an ideal guide for scientists investigating this prevalent and perilous RNA virus and the novel coronavirus disease that results from it.
Автор: Sunil K. Lal Название: Molecular Biology of the SARS-Coronavirus ISBN: 364242435X ISBN-13(EAN): 9783642424359 Издательство: Springer Рейтинг: Цена: 34150.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.
Автор: Cavanagh Название: SARS- and Other Coronaviruses ISBN: 1617378151 ISBN-13(EAN): 9781617378157 Издательство: Springer Рейтинг: Цена: 17074.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In 2003, the word "coronavirus" spread across the globe, somewhat further than the virus that sparked the panic. In this book, expert researchers examine these devastating viruses through 23 state-of-the-art, widely applicable protocols with minute detail.
Автор: Stanley Perlman; Kathryn Holmes Название: The Nidoviruses ISBN: 1441938745 ISBN-13(EAN): 9781441938749 Издательство: Springer Рейтинг: Цена: 34150.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases.
Описание: Although the governments of these countries based their Covid-19 strategy on science, scientists failed to have a decisive influence on decision-makers-except in China-, which created genuine "time bombs." The accelerated development of vaccines does not erase past months` errors.
Описание: As these begin to be deployed and administered across the globe, many now feel the virus will be brought under control and lives will eventually return to normal. This new volume will increase readers` understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns.
Автор: Saxena Название: Coronavirus Disease 2019 (COVID-19) ISBN: 9811548137 ISBN-13(EAN): 9789811548130 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chapter 1_Global trends in epidemiology of Coronavirus Disease 2019 (COVID-19). -Chapter 1.1. Introduction. -Chapter 1.2. 21st century SARS-CoV-2 outbreaks, epidemics. -Chapter 1.3.Worldwide surveillance systems. -Chapter 1.4. Regions of potential threat. -Chapter 1.5. Pandemic SARS-CoV-2. -Chapter 1.6. Conclusions. -Chapter 1.7. Future Perspectives. -Chapter 1.8. References. -Chapter 2_Genome organization and Pathogenesis of novel Coronavirus 2019 (SARS-CoV-2). -Chapter 2.1. Introduction. -Chapter 2.2. Structure and genome of SARS-CoV-2. -Chapter 2.3. Replication and life cycle of virus. -Chapter 2.3.1 Attachment. -Chapter 2.3.2.Entry. -Chapter 2.3.3. Receptors. -Chapter 2.3.4. Uncoating. -Chapter 2.3.5. Synthesis of viral RNA. -Chapter 2.3.6. Viral proteins . -Chapter 2.3.7. Egress. -Chapter 2.4. Conclusions. -Chapter 2.5. Future Perspectives. -Chapter 3_Host immune response against human SARS-CoV-2 infection.-Chapter 3.1. Introduction. -Chapter 3.2. Immune response. -Chapter 3.3. Humoral immune response. -Chapter 3.4.Cellular immune response. -Chapter 3.5. Conclusions. -Chapter 3.6. Future Perspectives. -Chapter 4_Emergence and Re-emergence of SARS Coronaviruses. -Chapter 4.1. Introduction. -Chapter 4.2. SARS-CoV to SARS-CoV-2: RNA recombination, antigenic shift and antigenic drift. -Chapter 4.3. Conclusions. -Chapter 4.4. Future Perspectives. -Chapter 5_Transmission cycle of SARS-CoV and SARS-CoV-2. . -Chapter 5.1. Introduction. -Chapter 5.2. Coronavirus Transmission cycle. -Chapter 5.2.1. Transmission among animals. -Chapter 5.2.2. Transmission in animals to human. -Chapter 5.2.3.Transmission among humans. -Chapter 5.2.4. Other hosts. -Chapter 5.3. Conclusions. -Chapter 5.4. Future Perspectives. -Chapter 6_Preparing for the perpetual challenges of pandemics of Coronavirus infections with special focus on SARS-CoV-2. -Chapter 6.1. Introduction. -Chapter 6.2. Strategies for pandemic preparedness for Coronavirus. -Chapter 6.2.1. Updated Surveillance system. -Chapter 6.2.2. Strategies for implementation of laboratory diagnostic services during pandemics. -Chapter 6.2.3. Management of bulk vaccines, antiviral drugs. -Chapter 6.3. Promoting facilities for treatment and hospitalisation, healthcare personnel, maintenance of hygiene and disinfection during pandemics. -Chapter 6.3.1.Global management strategies of Coronavirus infection. -Chapter 6.3.2.Economic Consequences of pandemic risk. -Chapter 6.3.3.Conclusions. -Chapter 6.3.4. Future Perspectives. -Chapter 7. Clinical manifestations and diagnosis of human SARS-CoV-2 infection. . -Chapter 7.1. Introduction. -Chapter 7.2. General Symptoms of SARS-CoV-2 infection. -Chapter 7.3. Clinical Course. -Chapter 7.4. Clinical complications. -Chapter 7.5. Diagnosis of SARS-CoV-2. -Chapter 7.6. Conclusions. -Chapter 7.7. Future Perspectives. -Chapter 8. Treatment and Drugs for SARS-CoV-2. . -Chapter 8.1. Introduction. -Chapter 8.2. Antiviral drugs for SARS-CoV-2. -Chapter 8.3. Current available drugs, Pharmacokinetics, Toxicity, Efficacy, Resistance, Drug Interactions, Recommendations for Use. . -Chapter 8.4. Complementary and alternative medicines for SARS-CoV-2. . -Chapter 8.5. Conclusions. -Chapter 8.6. Future Perspectives. -Chapter 9. Prevention and control strategies for SARS-CoV-2 infection. . -Chapter 9.1. Introduction. -Chapter 9.2. SARS-CoV-2 vaccine development. -Chapter 9.3. Types of Coronavirus vaccines. -Chapter 9.4. Efficacy and effectiveness of Coronavirus vaccines. -Chapter 9.5. Control strategies of Coronavirus infection. -Chapter 9.6. Conclusions
Автор: Barry Название: Studies to Combat COVID-19 using Science and Engineering ISBN: 9811913552 ISBN-13(EAN): 9789811913556 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This unique book provides excellent examples of ongoing, leading-edge research related to viruses, especially COVID-19. It is written from the viewpoint of various scientific fields including materials science. It introduces and describes viruses (submicroscopic infectious agents that replicate inside the living cells of an organism), various infections caused by viruses (human to human, human to other organisms to humans, humans to materials to humans, etc.), not only from the viewpoint of medical research but also from other scientific disciplines. A major focus of the book is the COVID-19 virus. Highlighted topics include the evolution of COVID-19, transmission of virus particles through the air, virus spread through various materials, detection of the virus by testing wastewater, the development and testing of vaccines and therapeutic drugs, and the preparation for future viruses and pandemics. This includes reform in funeral services to properly and safely accommodate very large numbers of bodies in a pandemic, like those seen in New York City when it was the epicenter for the virus in the United States. This book serves as an excellent and very informative guide (practical book) for engineers and researchers of various backgrounds and as a great academic textbook.
Автор: Andrews Gavin J., Crooks Valorie A., Pearce Jamie R. Название: Covid-19 and Similar Futures: Pandemic Geographies ISBN: 3030701786 ISBN-13(EAN): 9783030701789 Издательство: Springer Цена: 17074.00 р. Наличие на складе: Нет в наличии.
Описание: Although falling under a health geography book series, the book explores the centrality and importance of a full range of biological, material, social, cultural, economic, urban, rural and other geographies.
Автор: Guest Название: Multiplex Biomarker Techniques ISBN: 107162394X ISBN-13(EAN): 9781071623947 Издательство: Springer Рейтинг: Цена: 14635.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume explores the application of multiplex biomarker methods in the critical area of COVID-19 research through state-of-the-art technologies in the fields of genomics, proteomics, transcriptomics, metabolomics, and imaging.
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