This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials.
In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered.
The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.
Автор: Osborne, David W. Название: Topical Drug Delivery Formulations ISBN: 082478183X ISBN-13(EAN): 9780824781835 Издательство: Taylor&Francis Рейтинг: Цена: 9186.00 р. Наличие на складе: Нет в наличии.
Автор: Gad, Shayne C. Название: Nonclinical Drug Administration ISBN: 1466502533 ISBN-13(EAN): 9781466502536 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Нет в наличии.
Автор: Keservani Название: Advances in Novel Formulations for Drug Delivery ISBN: 1394166435 ISBN-13(EAN): 9781394166435 Издательство: Wiley Рейтинг: Цена: 29938.00 р. Наличие на складе: Поставка под заказ.
Описание: Hoe bestuur je een wendbare organisatie, of beter, hoe bestuur je een organisatie naar een blijvende wendbare organisatie?¢ Ben jij lid van het Managementteam (MT) of lid van de directie die de noodzaak tot verandering in besturing ziet, die de urgentie voelt om daar iets aan te doen en gehoor hiervoor wil vinden bij de collega leden van het MT of directie? ¢ Ben jij een coach in een organisatie die beweging richting een wendbare organisatie vooral bottom up ziet groeien, een beweging waar je de top down beweging aan toe wil voegen?. In deze pocketguide vind je een praktische methode hoe dit aan te pakken. Besturen in een steeds sneller veranderende wereld. Met de waan van de dag die vaak veel aandacht vraagt en die je kan afleiden van de te behalen resultaten. De auteurs gaan in op het operationaliseren van de strategische organisatiedoelen en daarmee het besturen van de gehele organisatie. De stellingname van dit boek is: maak scherp wat dit kwartaal bereikt moet worden om de strategische doelen te bereiken. Stuur kort cyclisch om te kunnen reageren op veranderende klantwensen of gewijzigde wet- en regelgeving. Werk samen als managementteam of directie richting dje strategische doelen en voorkom dat iedereen in de organisatie vooral een eigen doel nastreeft. Breng meer focus in de operationalisering van de strategie, minder met "brandjes" bezig zijn en meer met het voorkomen ervan. Krijg snel helder wat je medewerkers belemmert in hun werk. Lukt het om de belemmeringen in jouw organisatie snel op te lossen? De kern van deze pocketguide betreft het FOCUS- bord. Deze manier van visual management is een krachtig middel in de besturing. De toepassing ervan zorgt voor samenwerking tussen alle lagen in de organisatie, kort cyclisch sturen en focus op het behalen van de strategische doelen.
Автор: T?nnesen, Hanne Название: Photostability of Drugs and Drug Formulations ISBN: 0415303230 ISBN-13(EAN): 9780415303231 Издательство: Taylor&Francis Рейтинг: Цена: 56654.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Название: Photostability of Drugs and Drug Formulations ISBN: 0367394103 ISBN-13(EAN): 9780367394103 Издательство: Taylor&Francis Рейтинг: Цена: 10411.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource.
The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results. Features
Assists non-experts in this field design a test protocol and interpret the results
Covers in vitro and in vivo aspects of interactions between drugs and light
Explores the kinetic and chemical aspects of drug photodecomposition
Discusses the problems frequently encountered in photochemical stability testing
Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs
Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint
Offers specific guidance in photos
Автор: Hauss, David J. Название: Oral Lipid-Based Formulations ISBN: 0824729455 ISBN-13(EAN): 9780824729455 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Нет в наличии.
Название: Dermatological and Transdermal Formulations ISBN: 0367396343 ISBN-13(EAN): 9780367396343 Издательство: Taylor&Francis Рейтинг: Цена: 10411.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Containing 350 illustrations, tables, and equations and covering AAPS/FDA guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption, this reference provides comprehensive coverage of the development, preparation, and application of topical and transdermal therapeutic systems. Recognized international experts discuss the bioequivalence of dermatological and transdermal dosage forms. They explore the biochemistry and treatment of skin diseases, the structure and function of the skin, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation.
Автор: Khan, Anish Название: Hybrid Natural Fiber Composites ISBN: 0128199008 ISBN-13(EAN): 9780128199008 Издательство: Elsevier Science Рейтинг: Цена: 32844.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Research on natural fiber composites is an emerging area in the field of polymer science with tremendous growth potential for commercialization. Hybrid Natural Fiber Composites: Material Formulations, Processing, Characterization, Properties, and Engineering Applications provides updated information on all the important classes of natural fibers and their composites that can be used for a broad range of engineering applications. Leading researchers from industry, academia, government, and private research institutions from across the globe have contributed to this highly application-oriented book.
The chapters showcase cutting-edge research discussing the current status, key trends, future directions, and opportunities. Focusing on the current state of the art, the authors aim to demonstrate the future potential of these materials in a broad range of demanding engineering applications.
This book will act as a one-stop reference resource for academic and industrial researchers working in R&D departments involved in designing composite materials for semi structural engineering applications.
Автор: A. Knowles Название: Chemistry and Technology of Agrochemical Formulations ISBN: 0751404438 ISBN-13(EAN): 9780751404432 Издательство: Springer Рейтинг: Цена: 46347.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text covers issues around international product quality and safety standards, and describes the late-1990s and likely future trends which will carry the industry forward into the third millennium.
Автор: Stein W. Wallace Название: Algorithms and Model Formulations in Mathematical Programming ISBN: 3642837263 ISBN-13(EAN): 9783642837265 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop on Algorithms and Model Formulations in Mathematical Pro- gramming held in Bergen, Norway, June 15-19, 1987
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