Toll-Like Receptors: Practice and Methods, McCoy Claire
Автор: Tammy Kielian Название: Toll-like Receptors: Roles in Infection and Neuropathology ISBN: 3642269117 ISBN-13(EAN): 9783642269110 Издательство: Springer Рейтинг: Цена: 24392.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book highlights traditional roles for TLRs in infectious diseases of the CNS. It also discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands.
Автор: Claire McCoy Название: Toll-Like Receptors ISBN: 1493933337 ISBN-13(EAN): 9781493933334 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second edition volume expands on the first edition with new developments on Toll-Like Receptors (TLRs) controlling events such as cross-priming of associated pattern recognition receptors, post-transcriptional regulation, interaction with other cellular and biologic systems, and cancer progression.
Автор: Bruce Beutler; Hermann Wagner Название: Toll-Like Receptor Family Members and Their Ligands ISBN: 3642639755 ISBN-13(EAN): 9783642639753 Издательство: Springer Рейтинг: Цена: 14818.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: On occasion, the innate immune system is referred to as the "primitive" immune system. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due.
Описание: TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.
Автор: M. D. Cooper; T. Takai; J.V. Ravetch Название: Activating and Inhibitory Immunoglobulin-like Receptors ISBN: 4431679596 ISBN-13(EAN): 9784431679592 Издательство: Springer Рейтинг: Цена: 19377.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system.
Автор: Vivier Eric, Colonna Marco Название: Immunobiology of Natural Killer Cell Receptors ISBN: 3540260838 ISBN-13(EAN): 9783540260837 Издательство: Springer Рейтинг: Цена: 22797.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
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