Drug Metabolism in Diseases, Edited by Wen Xie, PhD, Professor of Pharmaceutica

Автор: Xie, Wen
Название: Drug Metabolism in Diseases
ISBN: 0128029498 ISBN-13(EAN): 9780128029497
Издательство: Elsevier Science
Цена: 17517.00 р.
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Описание:

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states.

Автор: Bradley J.
Название: Nelson`s Pediatric Antimicrobial Therapy - 28 ed.
ISBN: 1610025644 ISBN-13(EAN): 9781610025645
Издательство: Mare Nostrum (Eurospan)
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Цена: 6930.00 р.
Наличие на складе: Поставка под заказ.

Описание: Completely updated and revised, the 28th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select the best of all antimicrobial choices.

Автор: Caffrey
Название: Parasitic Helminths: Targets, Screens, Drugs and Vaccines
ISBN: 3527330593 ISBN-13(EAN): 9783527330591
Издательство: Wiley
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Цена: 12856.00 р. 18366.00 -30%
Наличие на складе: Есть (1 шт.)
Описание: The first title dealing with drug discovery against parasitic worms (Helminths) which include many of the major human and animal parasites. The book focusses on the development of novel drugs and vaccination strategies making it attractive for academia and industry alike.

Автор: Lyubimov
Название: Encyclopedia of Drug Metabolism and Interactions, 6-Volume Set
ISBN: 0470450150 ISBN-13(EAN): 9780470450154
Издательство: Wiley
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Цена: 271173.00 р.
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Описание: This multi-volume, state-of-the-art encyclopedia discusses all preclinical, clinical, toxicological, regulatory and marketing perspectives of drug metabolism and interactions. Methods and detailed protocols describing how to perform studies of metabolism and drug interactions are presented in one of the volumes.

Автор: Evans
Название: YB of Bioanalysis and Drug Metabolism,2003
ISBN: 0415275199 ISBN-13(EAN): 9780415275194
Издательство: Taylor&Francis
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Цена: 39046.00 р.
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Описание: An invaluable guide for pharmacology students and professionals which will help to reinforce the theory in the subject of drug metabolism, and help develop valuable analytical and interpreting skills.

Автор: Evans
Название: Guide to Bioanalysis and Drug Metabolism.2003
ISBN: 0415275202 ISBN-13(EAN): 9780415275200
Издательство: Taylor&Francis
Цена: 4592.00 р.
Наличие на складе: Нет в наличии.

Описание: Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. This textbook provides a guide for students of this field.

Автор: Zhang
Название: Drug Metabolism in Drug Design and Development - Basic Concepts and Practice
ISBN: 047173313X ISBN-13(EAN): 9780471733133
Издательство: Wiley
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Цена: 22643.00 р.
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Описание: Drug Metabolism in Drug Design and Development provides a practical description of what happens during the drug design and development process and focuses on issues such as: what data are needed; what experiments and analytical methods are typically employed; and how to interpret and apply data.

Автор: Helmer Erica
Название: Integrated Study of Drug Metabolism
ISBN: 1632420449 ISBN-13(EAN): 9781632420442
Издательство: Неизвестно
Цена: 27404.00 р.
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Название: Enzyme kinetics in drug metabolism
ISBN: 1627037578 ISBN-13(EAN): 9781627037570
Издательство: Springer
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Цена: 26832.00 р.
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Aparajita Dey
Название: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
ISBN: 9400758804 ISBN-13(EAN): 9789400758803
Издательство: Springer
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Цена: 22797.00 р.
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Описание: The book examines clinical aspects of cytochrome P450 2E1(CYP2E1), covering clinical disorders associated with changes in the regulation of CYP2E1 and consequent abnormalities including alcoholic liver disease, hepatitis C, inhibition of bone repair and more.

Автор: Younggil Kwon
Название: Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
ISBN: 147578693X ISBN-13(EAN): 9781475786934
Издательство: Springer
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Цена: 19514.00 р.
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Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.

Автор: Ronald T. Borchardt; Philip L. Smith; Glynn Wilson
Название: Models for Assessing Drug Absorption and Metabolism
ISBN: 1489918655 ISBN-13(EAN): 9781489918659
Издательство: Springer
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Цена: 25077.00 р.
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Описание: Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems.

Автор: Hamed Alborzinia
Название: Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing
ISBN: 3658101601 ISBN-13(EAN): 9783658101602
Издательство: Springer
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Цена: 9756.00 р.
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Описание: Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines;