Each week, people read about new and exciting cancer drugs. Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which
- promote novel cancer therapies long before credible data are available to support such treatment - exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars
Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.
This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,
- more cancer clinical trials should measure outcomes that actually matter to people with cancer; - patients on those trials should look more like actual global citizens; - we need drug regulators to raise, not perpetually lower, the bar for approval; and - we need unbiased patient advocates and experts.
This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.
Автор: Wittekind Название: TNM Atlas, 6th Edition ISBN: 1444332422 ISBN-13(EAN): 9781444332421 Издательство: Wiley Рейтинг: Цена: 11524.00 р. Наличие на складе: Поставка под заказ.
Описание: The complete, authoritative TNM cancer classification and staging system—now illustrated with new, full-colour figures for fast, effective, anatomical referencing Referring to “Tumour,” “Node,” and “Metastasis,&rdq
Название: Understanding mesothelioma ISBN: 1032631295 ISBN-13(EAN): 9781032631295 Издательство: Taylor&Francis Рейтинг: Цена: 7195.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Testa Joseph R. Название: Asbestos and Mesothelioma ISBN: 3319851837 ISBN-13(EAN): 9783319851839 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.
Автор: Giovanni Luca Ceresoli; Emilio Bombardieri; Mauriz Название: Mesothelioma ISBN: 3030168867 ISBN-13(EAN): 9783030168865 Издательство: Springer Рейтинг: Цена: 10366.00 р. Наличие на складе: Нет в наличии.
Описание: This book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research.
Автор: Robinson, Bruce W S Название: Mesothelioma ISBN: 9058231801 ISBN-13(EAN): 9789058231802 Издательство: Taylor&Francis Рейтинг: Цена: 26796.00 р. Наличие на складе: Нет в наличии.
Автор: Joseph R. Testa Название: Asbestos and Mesothelioma ISBN: 3319535587 ISBN-13(EAN): 9783319535586 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.
Название: Mesothelioma ISBN: 1685070752 ISBN-13(EAN): 9781685070755 Издательство: Nova Science Рейтинг: Цена: 13462.00 р. Наличие на складе: Невозможна поставка.
Описание: Mesothelioma is a type of cancer in which tumors form in the tissue that lines the lungs, heart, stomach, and other organs. While mesothelioma is relatively rare, it represents a serious health crisis as the disease is aggressive and often fatal. This book includes five chapters that detail the treatment and prognosis of the disease as well as the factors that put a person at risk for developing mesothelioma. Chapter One describes the most promising emerging immunotherapy combinations for the treatment of malignant pleural mesothelioma, discussing the biological rational underlying their development as well as the issues surrounding their clinical development. Chapter Two provides an overview of malignant mesothelioma, describing the history of its diagnosis and treatment as well as the role that asbestos exposure and other factors play in its development. Chapter Three revises the role of the main inflammatory and immunological markers as prognostic indicators in malignant pleural mesothelioma and discusses the surgical effects on immune response against cancer. Chapter Four explores the main cancer markers utilized for mesothelioma diagnosis as well as the new developments in the field. Lastly, Chapter Five examines the various surgical options available for removing pleural tumors.
Автор: Nakano Название: Malignant Pleural Mesothelioma ISBN: 9811591601 ISBN-13(EAN): 9789811591600 Издательство: Springer Рейтинг: Цена: 10976.00 р. Наличие на складе: Нет в наличии.
Описание: This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma.
Описание: This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma.
Автор: Galateau-Sall? Название: Pathology of Malignant Mesothelioma ISBN: 1852338725 ISBN-13(EAN): 9781852338725 Издательство: Springer Рейтинг: Цена: 23173.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The use of asbestos and its consequences is a global problem. This title aids in pathological diagnosis which is very difficult. It is of interest to members of legal profession specializing in this disease.
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