Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications, Shen
Автор: Hedaya, Mohsen A. Название: Basic Pharmacokinetics ISBN: 0367752158 ISBN-13(EAN): 9780367752156 Издательство: Taylor&Francis Рейтинг: Цена: 5817.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.
Название: Drug Metabolism, Pharmacokinetics and Bioanalysis ISBN: 3038979163 ISBN-13(EAN): 9783038979166 Издательство: Неизвестно Рейтинг: Цена: 9409.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Название: Pharmacokinetics and metabolism in drug design ISBN: 3527329544 ISBN-13(EAN): 9783527329540 Издательство: Wiley Рейтинг: Цена: 18525.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Bobbe L. Ferraiolo; Marjorie A. Mohler; Carol A. G Название: Protein Pharmacokinetics and Metabolism ISBN: 1489923314 ISBN-13(EAN): 9781489923318 Издательство: Springer Рейтинг: Цена: 22797.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents.
Автор: A. Pecile Название: Pharmacokinetics ISBN: 146845465X ISBN-13(EAN): 9781468454659 Издательство: Springer Рейтинг: Цена: 14818.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This unique feature of the Course is also the unique characteristic of this book which is therefore mainly directed to people interested not just in acquiring a working knowledge of the methods but in developing new methods.
Автор: I. Gut; M. Cikrt; G. L. Plaa Название: Industrial and Environmental Xenobiotics ISBN: 3642681972 ISBN-13(EAN): 9783642681974 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Sponsored by the Permanent Commission and International Association on Occupational Health
Описание: This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.
Описание: These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. Geared toward graduate level students and scientists in the areas of clinical pharmacology and PK, the volumes will fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs, including first-time-in-man, biopharmaceuticals, and special population studies. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.
Описание: These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. Geared toward graduate level students and scientists in the areas of clinical pharmacology and PK, the volumes will fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs, including first-time-in-man, biopharmaceuticals, and special population studies. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.
Автор: Schoenwald Название: Pharmacokinetics in Drug Discovery and Development ISBN: 1566769736 ISBN-13(EAN): 9781566769730 Издательство: Taylor&Francis Рейтинг: Цена: 30624.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: From basic principles to industrial and regulatory applications to clinical and research applications, this book reviews the subspecialties in the field of pharmacokinetics. It covers topics such as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, and linear systems approaches.
Автор: Bonate Название: Pharmacokinetics in Drug Development ISBN: 3319390511 ISBN-13(EAN): 9783319390512 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.
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