Target Volume Delineation in Hematologic Malignancies, Chelsea Pinnix

Автор: Bhargava
Название: Hematologic Malignancies
ISBN: 9813348011 ISBN-13(EAN): 9789813348011
Издательство: Springer
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Цена: 20733.00 р.
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Описание: This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail.

Автор: Blake Copland
Название: Hematologic Malignancies: An Overview
ISBN: 1536181242 ISBN-13(EAN): 9781536181241
Издательство: Nova Science
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Цена: 32312.00 р.
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Описание: Ineffective haematopoiesis in bone marrow and peripheral cytopenias are features of bone marrow failure and related syndromes. These diseases can progress to myelodysplastic syndrome, acute myeloid leukaemia, and other malignancies. Acute myeloid leukaemia is a heterogeneous complex malignancy characterized by proliferating myeloblasts in the bone marrow and a diverse range of recurrent molecular aberrations that occur in many different combinations. More specifically, the authors explore the McDonough strain of feline sarcoma virus-related tyrosine kinase 3 receptor mutations present in about 30-35% of acute myeloid leukaemia patients. The way in which the Wnt signalling pathway plays an important role in normal haematopoiesis and its deregulation associated with acute myeloid leukaemia is also discussed. This compilation also explores the importance of residual leukemic cells in disease relapse prognosis, as the new definition of the European LeukemiaNet for complete remission includes minimal or measurable residual disease negativity. Mutations detected in patients with clonal haematopoiesis are addressed, including those which most commonly affect DNMT3A, ASXL1, TET2, JAK2, SF3B1, SRSF2, and TP53 genes that had previously been identified as drivers in various myeloid neoplasms. The authors provide an overview of the roles of extracellular vesicles in multiple myeloma, their capacity as emerging biomarkers, and implications for liquid biopsy for detection and monitoring. The penultimate study focuses on toll-like receptors, which play an essential role in the recognition of invading pathogens via specific microbial molecular motifs, forming a bridge between the innate and adaptive immune responses. In conclusion, this compilation explores PROTACs, proteolysis targeting chimeras, which mediate the degradation of proteins of interest by hijacking the activity of E3-ubiquitin ligases for POI polyubiquitination and subsequent degradation by proteasome.

Автор: A. Clarysse; G. Mathe
Название: Cancer Chemotherapy
ISBN: 3540070559 ISBN-13(EAN): 9783540070559
Издательство: Springer
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Цена: 9756.00 р.
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Автор: J.V. Melo; J. Goldman
Название: Myeloproliferative Disorders
ISBN: 3642421121 ISBN-13(EAN): 9783642421129
Издательство: Springer
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Цена: 14635.00 р.
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Описание: This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. A feature of this book is the speed with which it has been produced - an important factor in this rapidly moving field.

Автор: Lenz
Название: Aggressive Lymphomas
ISBN: 3030003612 ISBN-13(EAN): 9783030003616
Издательство: Springer
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Цена: 15855.00 р.
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Описание: This book summarizes current knowledge of the biology and molecular pathogenesis of aggressive lymphomas and reviews the state of the art in diagnostic and therapeutic strategies.

Автор: David A. Sallman, Ateefa Chaudhury, Johnny Nguyen,
Название: Handbook of Hematologic Malignancies
ISBN: 1620700948 ISBN-13(EAN): 9781620700945
Издательство: Mare Nostrum (Eurospan)
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Цена: 16610.00 р.
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Описание: Provides a unique, practical, and concise guide focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. This comprehensive subspecialty handbook is designed and organised for the busy hematologist, hematologic oncologist, hematopathologist, and trainee.

Автор: Hehlmann Rьdiger
Название: Chronic Myeloid Leukemia
ISBN: 303071912X ISBN-13(EAN): 9783030719128
Издательство: Springer
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Цена: 9756.00 р.
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Описание: This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health.

Автор: Hehlmann
Название: Chronic Myeloid Leukemia
ISBN: 3030719154 ISBN-13(EAN): 9783030719159
Издательство: Springer
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Цена: 9756.00 р.
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Описание: This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health.

Автор: Martin S. Tallman; Leo I. Gordon
Название: Diagnostic and Therapeutic Advances in Hematologic Malignancies
ISBN: 1475782675 ISBN-13(EAN): 9781475782677
Издательство: Springer
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Цена: 36589.00 р.
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Автор: Guy B. Faguet
Название: Hematologic Malignancies
ISBN: 1489942165 ISBN-13(EAN): 9781489942166
Издательство: Springer
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Цена: 12196.00 р.
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Описание: The aim of Hematologic Malignancies: Methods and Techniques is to review those methods most useful for the diagnosis and subsequent mana- ment of hematologic malignancies.

Автор: Hays
Название: Cancer Immunotherapies
ISBN: 3030963756 ISBN-13(EAN): 9783030963750
Издательство: Springer
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Цена: 12196.00 р.
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Описание: This book presents the clinical scope of cancer immunotherapeutic agents for solid tumors and Hematologic malignancies, elaborates on the scientific details of their modes of action, and presents the impact of these agents on oncology, patients and the broader healthcare system. At present, cancer immunotherapies fall broadly into three categories: immune checkpoint inhibitors (ICIs), adoptive T cell therapies, and cancer vaccines which have distinct mechanisms of action. Immune checkpoint inhibitors rely upon disrupting tumor antigen recognition as self by the immune system through inhibition of checkpoint molecules. Adoptive T cell therapies involve the engineering of T cells ex vivo to target and destroy tumor cells. The first part of this book will provide an overview of the discovery and mechanistic details of the technology. The second part will be devoted to elaborating on the clinical outcomes, successes and limitations for specific tumor subtypes, which includes both solid tumors and hematologic malignances for both pediatric and adult populations. As such, the book offers a valuable resource for oncologists, hematologists, and all those seeking an up-to-date overview of cancer immunotherapies.

Автор: Dreyling
Название: Rare Lymphomas
ISBN: 3642395899 ISBN-13(EAN): 9783642395895
Издательство: Springer
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Цена: 20123.00 р.
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Описание: After a decade of tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma, optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors.