This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Mishra Название: Nanomedicine for Drug Delivery and Therapeutics ISBN: 1118414098 ISBN-13(EAN): 9781118414095 Издательство: Wiley Рейтинг: Цена: 20507.00 р. 29296.00-30% Наличие на складе: Есть (1 шт.) Описание: This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.
Автор: Kazunari Taira; Kazunori Kataoka; Takuro Niidome Название: Non-viral Gene Therapy ISBN: 443154738X ISBN-13(EAN): 9784431547389 Издательство: Springer Рейтинг: Цена: 18237.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1 Molecules for Gene Delivery 1-1 Leaf Huang Recent Progress in Nonviral Gene Delivery 1-2 Kenichi Yoshikawa Physical Chemistry of DNA-Carrier Complex 1-3 Kazuo Maruyama Liposome-Mediated Delivery System 1-4 Tomoko Hashimoto Polymeric Gene Carriers 1-5 Kazunori Kataoka Development of Cationic Block Copolymer-Based Gene Delivery System 1-6 Toshinori Sato Chitosan-Mediated Gene Delivery 1-7 Hidetoshi Arima Dendrimers as DNA Carriers 1-8 Takuro Niidome Use of Synthetic Peptide for Non-viral Gene Delivery 1-9 Kazuo Sakurai Oligonucleotide Carrier Based on b-1,3-Glucans 1-10 Mahito Nakanishi Biological and Chemical Hybrid Vectors 2 Controlled Gene Delivery 2-1 Hideyoshi Harashima Pharmacokinetics of Gene Delivery in Cells 2-2 Takeshi Nagasaki Active DNA Release from Complex 2-3 Masayuki Yokoyama Controlled Release of DNA using Thermo-Responsive Polymers 2-4 Takeshi Nagasaki Active Transport of Exogenous Gene into Nucleus 2-5 Masayuki Fujii Controlled Intracellular Localization of Oligonucleotides by Chemical Conjugation 2-6 Osam Mazda Functional Nucleotide Sequences Capable of Promoting Nonviral Genetic Transfer 2-7 Yoshiyuki Koyama Shielding of cationic charge of the DNA complex to avoid non-specific interactions for in vivo gene delivery 2-8 Shigeru Kawakami In Vivo Gene Transfer by Ligand Modified Gene Carriers 2-9 Ernst Wagner Optimizing Polyplexes into Systemic Viruses for Tumor-Targeted Gene Therapy 2-10 Mariko Harada-Shiba Gene Transfer and Target Diseases 2-11 Hironobu Yanagie Clinical Trials Using Non-Viral Gene Delivery Systems 3 Current Protocoles of Gene Delivery 3-1 Mitsuru Hashida Evaluation of Size and Zeta-Potential of DNA/Carrier Complex 3-2 Tomoko Ito Observation of DNA / Carrier Complex under Fluorescence Microscopy 3-3 Taku Satoh Synthesis of Chemically Modified Chitosan and its Gene Transfection Efficiency 3-4 Hiroyuki Kamiya Newly Designed DNA Fragments for Gene Correcton 3-5 Tatsuya Okuda Evaluation of Gene Expression in Vivo after Intraveous and Intraportal Administration of Lipoplexes 3-6 Takuro Niidome Evaluation of DNA Administrated with Gene Carrier in Organs by Southern Blot Hybridization 3-7 Fuminori Sakurai Evaluation of Immune Response after Administration of Plasmid DNA-Nonviral Vector Complex 3-8 Kunt R. Madden Gateway RNAi 4 Design of Genes Based on Current RNA Technology 4-1 Kazunari Taira Design of Intracellulary Active Ribozymes and siRNA 4-2 Takanori Yokota siRNA-based Inhibition Specific for Mutant Allele in Autosomal Dominant Diseases: Sequence-Dependent and -Independent Discriminations of Mutant and Wild-type Alleles by siRNA 4-3 Silvere Petit In Vivo RNA Interference: another tool in the box? 4-4 Hiroaki Kawasaki Suppression of Gene Expression via Chromatin Remodeling and the siRNA-Induced Silencing of Transcription 4-5 Andrew Miller Intracellular delivery of nucleic acids: differences between transfection and siFection reflect differences between DNA and RNA, and between oligodeoxynucleotides and oligonucleotides 4-6 Junichi Yano In Vivo Antitumour Activity of a New Cationic Liposome siRNA Complex 4-7 John Rossi Enhancing RNAi with Synthetic RNA Duplexes
Автор: Shegokar Название: Viral Drug Delivery Systems ISBN: 3031205367 ISBN-13(EAN): 9783031205361 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems The third volume of series is focused on viral drug delivery systems. Typically, virus attaches to the cells (referred as host cell) and releases its DNA or RNA inside the cell. In second stage, virus’s genetic material takes control of the cell and forces it to replicate the virus leading to onset of disease symptoms. DNA class of viruses include Herpes, Papilloma and Adeno viruses. RNA class of viruses include retroviruses, such as HIV immunodeficiency virus and SARS COV – 2 / Corona virus. This book addresses recent developments in viral drug delivery systems. It covers many different aspects of viral infections, ways to treat them using modern drug delivery systems like nano particulate carriers. The choice of viral delivery systems mainly depends upon the type of virus, duration of life cycle, presence of drug resistance, cellular and mucosal interaction of virus, accordingly gene or non-gene drug delivery systems are selected. Besides that, this book also reports global dynamics of viral diseases, future predictions of infection rate, current treatment options, details of drug carriers like nanoemulsions, polymeric nanoparticles, role of biofunctionalization, and phyto-molecules in treatment of viral infections particularly herpes, Covid-19, Ebola, HIV/AIDS, influenza and viral hepatitis. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of viral drug delivery research.
Автор: Rehman, Nahid (motilal Nehru National Inst. Of Tech., Allahabad, India) Pandey, Anjana (mnnit Allahabad, India) Название: Engineered nanoparticles as drug delivery systems ISBN: 1032171766 ISBN-13(EAN): 9781032171760 Издательство: Taylor&Francis Рейтинг: Цена: 15004.00 р. Наличие на складе: Нет в наличии.
Описание: This book highlights application of nanomaterials for drug delivery, therapy, and engineering. It covers stimuli-sensitive drug delivery systems including an overview of the physical, chemical, biological, and multi-stimuli-responsive nanosystems. It also presents analysis of clinical status for different types of nanoplatforms and assesses novel applications of nanomaterials in the areas of smart delivery and drug targeting. It further discusses the advantages and disadvantages of each application of pertinent nanomaterials.Features:Provides academic introduction to the uses of nanotechnology in drug delivery.Discusses use of nanomaterials in targeting a drug to specific tissues and cells.Presents an analysis of clinical status for different types of nanoplatforms.Covers applications in drug delivery, therapy, and engineering.Focuses on how novel nanotechnology-orientated methods can help improve treatment.This book is aimed at researchers and graduate students in biomedical and biochemical engineering, pharmaceutical, chemical and bioprocess engineering, materials science, and drug delivery mechanisms.
Автор: Keservani Raj K., Sharma Anil K., Kesharwani Rajesh Kumar Название: Recent Advances in Drug Delivery Technology ISBN: 152250754X ISBN-13(EAN): 9781522507543 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 26961.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Technological innovations have become the impetus for continuous developments in medical research. With the assistance of new technologies, effective drug delivery techniques have been improved for optimal patient care.Recent Advances in Drug Delivery Technology is a pivotal reference source for the latest scholarly research on the application of pharmaceutical technology to optimize techniques for drug delivery in patients. Focusing on novel approaches in pharmaceutical science, this book is ideally designed for medical practitioners, upper-level students, scientists, and researchers.
Автор: Laszlo Prokai; Katalin Prokai-Tatrai Название: Peptide Transport and Delivery into the Central Nervous System ISBN: 3034894201 ISBN-13(EAN): 9783034894203 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The general characteristics of neuropeptides are discussed as a background for the understanding of their role in regulation of physiological systems. The extent of those systems that are crucially affected by neuropeptides is vast and the complexity of their interactions makes the clinical focus on a specific neu- ropeptide unsatisfactory. The clinical potential of neuropeptides affecting eating disorders, eNS behavioral disorders and the neuroregenerative and neuroprotective action of neuropeptides is discussed. It is probable that suc- cessful neuropeptide therapeutics will depend upon the application of trans- lational and combinational research using various ingenious combinations and antagonists, neuropeptide receptor ago- of neuropeptides, their agonists nists and antagonists, improved methods of delivery and the development of peptides targeted to the genetic profile of individual patients. References 1 DeWied D (1969) Effects of peptide hormones on behavior. In: WF Ganong, L Martini (eds): Frontiers in Neuroendocrinology. Oxford University Press, New York, 97-140 2 Sandman CA, Schally AV, Kastin AJ, Miller L H (1972) A neuroendocrine influence on attention and memory. J Comp Physiol Psychol80: 54-58 3 Kastin AJ, Olson RD, SchaUy A V, Coy DH (1979) CNS effects of peripherally adminis- tered brain peptides. Life Sci 25: 401-414 4 Strand FL, Saint-Come C, Lee TS, Lee SJ, Kume JA, Zuccarelli LA (1993) An ACTH/MSH 4-10 analog BIM 22015 has neurotrophic and myotrophic attributes during peripheral nerve regeneration. Peptides 14: 287-296 5 Strand FL (1999) Neuropeptides: Regulators ofPhysiologjcal Processes.
Автор: Seyfoddin, Ali Название: Engineering Drug Delivery Systems ISBN: 0081025483 ISBN-13(EAN): 9780081025482 Издательство: Elsevier Science Рейтинг: Цена: 29476.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Engineering of Biomaterials for Drug Delivery Systems is an essential resource on a variety of biomaterials engineering approaches for creating drug delivery systems that have a great therapeutic and market potential. The book comprehensively discusses recent advances in the fields of biomaterials and biomedical sciences in relation to drug delivery.
The book's early chapters provide a detailed introduction to various engineering approaches in designing drug delivery systems, in addition to discussing regulatory requirements and potential pathways to market. The middle section of the book delves into the engineering of body functions, encompassing simulation of physiological environments and body functions in drug delivery, as well as covering the selection, design and evaluation of biomaterials and discussing the engineering of colloids as drug carriers. The book's final chapters address the engineering of implantable drug delivery systems and advances in drug delivery technology such as 3D printing, stimuli-responsive drug delivery systems, and biological and cell-based drug delivery systems, as well as discussing the future of novel drug delivery systems.
This book is an invaluable resource for drug delivery, materials scientists and bioengineers within the pharmaceutical industry.
Examines the properties and synthesis of biomaterials for successful drug delivery
Discusses the important connection between drug delivery and tissue engineering
Includes techniques and approaches applicable to a wide range of users
Reviews innovative technologies in drug delivery systems such as 3-D printed devices for drug delivery
Название: Drug delivery systems ISBN: 9813201045 ISBN-13(EAN): 9789813201040 Издательство: World Scientific Publishing Рейтинг: Цена: 20592.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
With the alarming increase in cancer diagnoses and genetic illnesses, traditional drug agents and their delivery media need to be re-evaluated to address a quickly evolving field. With newer smart materials for the controlled release of macromolecules, peptides, genetic material, etc. further complications arise, such as material performance, synthesis, functionalization and targeting, biological identity, and biocompatibility.
The book provides a comprehensive overview of the recent developments on "smart" targeting and drug delivery systems with a variety of carriers like nanoparticles, membranes, and hydrogels. It contains detailed descriptions on the recent trends in this field in the ongoing battle with catastrophic diseases like cancer. This field of research has been in its infancy and continues to face growth, and with it, further challenges and difficulties along the way toward maturity, which are accurately introduced in this book.
Автор: Lee, Vincent Название: Peptide and Protein Drug Delivery ISBN: 0824778960 ISBN-13(EAN): 9780824778965 Издательство: Taylor&Francis Рейтинг: Цена: 19906.00 р. Наличие на складе: Нет в наличии.
Автор: Patel, Deepa H. Название: Bioresponsive Polymers ISBN: 1774638975 ISBN-13(EAN): 9781774638972 Издательство: Taylor&Francis Рейтинг: Цена: 12707.00 р. Наличие на складе: Нет в наличии.
Автор: Vergnaud, Jean-Maurice Название: Assessing Bioavailablility of Drug Delivery Systems ISBN: 0849330440 ISBN-13(EAN): 9780849330445 Издательство: Taylor&Francis Рейтинг: Цена: 35983.00 р. Наличие на складе: Нет в наличии.
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