Название: Dihydropyrimidinones as potent anticancer agents ISBN: 0443190941 ISBN-13(EAN): 9780443190940 Издательство: Elsevier Science Рейтинг: Цена: 20380.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Sigel Astrid, Sigel Helmut, Freisinger Eva Название: Metallo-Drugs: Development and Action of Anticancer Agents ISBN: 3110469847 ISBN-13(EAN): 9783110469844 Издательство: Walter de Gruyter Цена: 80810.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Описание: Proceedings of the 18th Annual Detroit Cancer Symposium, Detroit, Michigan, USA, June 13-14, 1986
Автор: Bimal Krishna Banik, Bubun Banerjee Название: Heterocyclic Anticancer Agents ISBN: 3110739267 ISBN-13(EAN): 9783110739268 Издательство: Walter de Gruyter Рейтинг: Цена: 39051.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.
Название: Anticancer Agents: Design, Synthesis and Evaluation ISBN: 3036501401 ISBN-13(EAN): 9783036501406 Издательство: Неизвестно Рейтинг: Цена: 22056.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book is a printed edition of the Special Issue entitled "Anticancer Agents: Design, Synthesis and Evaluation" that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Автор: Carmen Avendano Название: Medicinal Chemistry of Anticancer Drugs ISBN: 0444626492 ISBN-13(EAN): 9780444626493 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Нет в наличии.
Описание: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. . Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. . Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.
Автор: Snapka, Robert M. Название: The SV40 Replicon Model for Analysis of Anticancer Drugs ISBN: 0126536309 ISBN-13(EAN): 9780126536300 Издательство: Elsevier Science Рейтинг: Цена: 14654.00 р. Наличие на складе: Нет в наличии.
Автор: Kunnumakkara Ajaikumar B Название: Anticancer Properties Of Fruits And Vegetables: A Scientific Review ISBN: 9814508888 ISBN-13(EAN): 9789814508889 Издательство: World Scientific Publishing Рейтинг: Цена: 20592.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An Estimated 12.6 Million People Are Diagnosed With Cancer Every Year And 7.6 Million People Die Of The Disease Annually. Numerous Lines Of Evidence Suggest That Lifestyle And Nutrition Play An Important Role In Cancer Development. As For Nutrition, Diets That Are Rich In Fruits And Vegetables Have Been Shown To Lower The Risk Of Cancer Incidence. In Addition, Several Phytochemicals That Are Present In Fruits And Vegetables Have Been Scientifically Established To Have Properties That Can Prevent And Treat This Malevolent Disease.The Primary Aim Of The Book Is To Educate The Public About The Benefits Of Fruits And Vegetables As They Relate To Cancer And Their Potential To Contribute To The Possibility Of A Cancer-Free Life. The Active Ingredients And Modes Of Actions Of Fruits And Vegetables Are Also Discussed, Along With Their Chemo-Preventive Aspects.This Clearly Written, Comprehensive Guide Explains The Properties Of These Natural Foods And Substances On A Cancer-By-Cancer Basis. Thus, This Book Not Only Informs The General Public About The Anticancer Properties Of Fruits And Vegetables But Also Provides A Valuable Reference For Scientists And Other Professionals Working In This Area.
Автор: Madkour, Loutfy H. Название: Nucleic Acids As Gene Anticancer Drug Delivery Therapy ISBN: 0128197773 ISBN-13(EAN): 9780128197776 Издательство: Elsevier Science Рейтинг: Цена: 26107.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.
Автор: Andrzej ?wierniak; Marek Kimmel; Jaroslaw Smieja; Название: System Engineering Approach to Planning Anticancer Therapies ISBN: 3319280937 ISBN-13(EAN): 9783319280936 Издательство: Springer Рейтинг: Цена: 10366.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well.
Автор: Teicher Название: Anticancer Drug Development Guide. 2ed.2004 ISBN: 1588292282 ISBN-13(EAN): 9781588292285 Издательство: Springer Рейтинг: Цена: 30370.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thoroughly updated and expanded second edition of Beverly Teicher's widely used classic survey provides a step-by-step guide to anticancer drug development from initial design through FDA approval. The authors have included new material on the use of high throughput screening in industry, on specialized in vitro/in vivo procedures employed by the National Cancer Institute (NCI) in preclinical drug evaluations, and on nonclinical testing to support both human clinical trials, as well as trials of biologic oncology products. The chapters on phase I, II, and III clinical trials and on novel phase II clinical trial designs for targeted therapies have been significantly updated, along with those on cancer drug development in Europe, working with the NCI, and the FDA's role in cancer drug development and setting requirements for approval.
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