Drug Repurposing: Advances, Scopes and Opportunities in Drug Discovery, Mithun Rudrapal
Название: Drug Repurposing and Computational Drug Discovery ISBN: 1774912775 ISBN-13(EAN): 9781774912775 Издательство: Taylor&Francis Рейтинг: Цена: 22509.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Cavalla David Название: Drug Repurposing ISBN: 1788019032 ISBN-13(EAN): 9781788019033 Издательство: Royal Society of Chemistry Рейтинг: Цена: 45923.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Drug Repurposing provides an ideal introduction to the field of drug repositioning and repurposing with contributions from world-renowned experts culminating in an excellent resource for any drug discovery or medicinal chemist.
Автор: Roy, Kunal Название: In Silico Drug Design ISBN: 0128161256 ISBN-13(EAN): 9780128161258 Издательство: Elsevier Science Рейтинг: Цена: 23075.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design.
Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing
Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases
Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing
Описание: This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.
Описание: This book comprehensively reviews current and novel treatment strategies against human parasites, including protozoans and helminths, using natural products. The initial chapters summarize the conventional treatment strategies and natural-product based therapeutics against these parasites. It discusses biochemical tools and techniques for the discovery of natural product based drugs against human parasites. The book also covers the ingenious and innovative mechanisms to achieve drug resistance by the protozoan parasites and strategies to overcome the resistance. It entails mechanistic insight into the modulation of host immune responses to delay or inhibit parasite clearance and explores host-pathogen interactions that mediate immunity against subsequent parasite challenge. In turn, the volume helps in understanding the immunobiology of the parasites and tools to identify candidate vaccine antigens and novel delivery systems against the protozoan parasites. Lastly, it explores the role of advanced methods, including nanotechnology, marine bioprospecting, and microorganisms-derived biochemicals against the protozoan parasites. This book is useful for students and researchers of pharmacology, parasitology, zoology and other allied fields.
Автор: Willers Henning, Eke Iris Название: Molecular Targeted Radiosensitizers: Opportunities and Challenges ISBN: 3030497038 ISBN-13(EAN): 9783030497033 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Introduction
Translating targeted radiosensitizers into the clinic [include focus on normal tissue toxicity
Mechanisms and markers of clinical radioresistance
Pre-clinical screening of targeted radiosensitizers
3D radiation biology for studying radiosensitizers
In vivo determinations of local tumor control and radiosensitzers
GEMMs for studying radiosensitizers
Pre-clinical models for studying radioresistance of GBM [include focus on PD/PK]
Targeting the DNA damage response for radiosensitization [include focus on scheduling]
Targeting metabolomics to overcome radioresistance
Targeting cancer stem cells to overcome radioresistance
Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.
Автор: Giovanni Melillo Название: Hypoxia and Cancer ISBN: 1493953559 ISBN-13(EAN): 9781493953554 Издательство: Springer Рейтинг: Цена: 18237.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ГЇВїВЅ ГЇВїВЅ ГЇВїВЅ The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues.
Название: Hypoxia and Cancer ISBN: 1461491665 ISBN-13(EAN): 9781461491668 Издательство: Springer Рейтинг: Цена: 22797.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ГЇВїВЅ ГЇВїВЅ ГЇВїВЅ The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues.
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