This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Villa Tomбs G., Viсas Miguel Название: Horizontal Gene Transfer: Breaking Borders Between Living Kingdoms ISBN: 3030218643 ISBN-13(EAN): 9783030218645 Издательство: Springer Рейтинг: Цена: 14025.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book focuses on the evolutionary impact of horizontal gene transfer processes on pathogenicity, environmental adaptation and biological speciation. Newly acquired genetic material has been considered as a driving force in evolution for prokaryotic genomes for many years, with recent technical developments advancing this field further. However, the extent and implications of gene transfer between prokaryotes and eukaryotes still raise controversies. This multi-authored volume introduces various means by which DNA can be exchanged, covers gene transfer between prokaryotes and their viruses as well as between bacteria and eukaryotes, such as fungi, plants and animals, and addresses the role of horizontal gene transfer in human diseases. Aspects discussed also include the relevance for virulence and drug resistance development on one hand, and for the occurrence of naturally derived antibiotics and other secondary metabolites on the other hand. This book offers new insights to anyone interested in genome evolution and the exchange of DNA between the different domains of life, the genetic toolkit for adaptation and the emergence of multidrug resistant bacteria.
Автор: Peter Vadasz Название: Emerging Topics in Heat and Mass Transfer in Porous Media ISBN: 1402081774 ISBN-13(EAN): 9781402081774 Издательство: Springer Рейтинг: Цена: 19377.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The very first major reference text on this topic, this book provides a unique collection of articles reviewing the state of the art in the field.
Описание: Biotechnology is referred to as one of the key enabling technologies of the 21st century. It has the potential to offer solutions for a number of health and resource-based problems the world is facing, such as unmet medical needs and fossil fuel dependency.
Автор: Ajay Babu Pazhayattil Название: Technology Transfer ISBN: 3031322193 ISBN-13(EAN): 9783031322198 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Нет в наличии.
Описание: Currently, there are no textbooks on drug product manufacturing technology transfer that incorporate the latest regulatory expectations. Recent guidance from regulatory bodies such as the US FDA, EMEA, WHO, and PIC/S has adopted the ICH Lifecycle approach harmonizing concepts across regulatory guidance. This allows organizations to align their technology transfer activities for all regulated markets. However, there is a need for consensus and direction in approaching technology transfer, particularly in understanding how to manage the scale-up effects to ensure regulatory compliance. This textbook offers technology transfer solutions and guidance to the pharmaceutical industry. The chapters provide a systematic understanding of applying the technology transfer concepts in pharmaceutical manufacturing, promoting standardization within the industry. Since Stage 1b is not specified in detail within the regulations, pharmaceutical organizations are left to determine the requirementsof the stage. The need to justify the methodologies and utilization of sound science makes it more demanding. The textbook’s authors provide innovative solutions for technology transfer challenges, making it a comprehensive reference document. The approaches can be applied to both small-molecule and large-molecule drug product manufacturing segments, addressing the unmet needs of the industry.
Автор: Ingo Potrykus; German Spangenberg Название: Gene Transfer to Plants ISBN: 3642489672 ISBN-13(EAN): 9783642489679 Издательство: Springer Рейтинг: Цена: 14818.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Scherman Daniel Название: Advanced Textbook On Gene Transfer, Gene Therapy And Genetic ISBN: 1786347059 ISBN-13(EAN): 9781786347053 Издательство: World Scientific Publishing Рейтинг: Цена: 12672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Hans-J?rg Bart Название: Reactive Extraction ISBN: 3642074308 ISBN-13(EAN): 9783642074301 Издательство: Springer Рейтинг: Цена: 17096.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: After an introductory chapter there is in Chapter 2 an intensive discussion of reactive phase equilibria of ionic and non-ionic solutes based on chemical potentials.
Автор: Twyman, Richard Название: Gene Transfer to Animal Cells ISBN: 1859962041 ISBN-13(EAN): 9781859962046 Издательство: Taylor&Francis Рейтинг: Цена: 5205.00 р. Наличие на складе: Нет в наличии.
Автор: Gresshoff, Peter M. Название: Technology Transfer of Plant Biotechnology ISBN: 0849382653 ISBN-13(EAN): 9780849382659 Издательство: Taylor&Francis Рейтинг: Цена: 34452.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: HRTF and sound localization in the horizontal and median planes are then explained, followed by discussion of individual differences in HRTF, solutions to this individuality (personalization of HRTF), and methods of sound image control for an arbitrary 3D direction, encompassing both classic theory and state of the art data.
Автор: Marcelo Tigre Moura Название: Somatic Cell Nuclear Transfer Technology ISBN: 1071630660 ISBN-13(EAN): 9781071630662 Издательство: Springer Рейтинг: Цена: 14635.00 р. Наличие на складе: Нет в наличии.
Описание: This volume details protocols on animal cloning by Somatic cell nuclear transfer for basic research and biotechnological applications. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Somatic Cell Nuclear Transfer Technology aims to be comprehensive guide for researchers.
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