Battling Resistance to Antibiotics and Pesticides, Laxminarayan, Ramanan
Автор: Carsten Str?by Jensen; S?ren Beck Nielsen; Lars Fy Название: Risking Antimicrobial Resistance ISBN: 3030080676 ISBN-13(EAN): 9783030080679 Издательство: Springer Рейтинг: Цена: 9756.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antimicrobial resistance (AMR) is predicted to be one of the greatest threats to public health in the twenty-first century. In this context, understanding the reasons why perceptions of antibiotic risk differ between different groups is crucial when it comes to tackling antibiotic misuse. This innovative volume gathers together chapters written by sociologists, psychologists and linguists with the common aim of examining the social factors that affect use of antibiotics among humans and animals. A unique focus on Denmark – one of the world’s most progressive countries when it comes to antibiotic regulation – as well as Europe more broadly, makes this book a valuable resource for regulatory deliberations on future antibiotic policy to effectively combat AMR.
Автор: Jensen Название: Risking Antimicrobial Resistance ISBN: 3319906550 ISBN-13(EAN): 9783319906553 Издательство: Springer Рейтинг: Цена: 9756.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antimicrobial resistance (AMR) is predicted to be one of the greatest threats to public health in the twenty-first century. In this context, understanding the reasons why perceptions of antibiotic risk differ between different groups is crucial when it comes to tackling antibiotic misuse. This innovative volume gathers together chapters written by sociologists, psychologists and linguists with the common aim of examining the social factors that affect use of antibiotics among humans and animals. A unique focus on Denmark – one of the world’s most progressive countries when it comes to antibiotic regulation – as well as Europe more broadly, makes this book a valuable resource for regulatory deliberations on future antibiotic policy to effectively combat AMR.
Автор: Cox Jr. Название: Quantitative Health Risk Analysis Methods ISBN: 1441938508 ISBN-13(EAN): 9781441938503 Издательство: Springer Рейтинг: Цена: 21343.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book grew out of an effort to salvage a potentially useful idea for greatly simplifying traditional quantitative risk assessments of the human health consequences of using antibiotics in food animals. In 2001, the United States FDA's Center for Veterinary Medicine (CVM) (FDA-CVM, 2001) published a risk assessment model for potential adverse human health consequences of using a certain class of antibiotics, fluoroquinolones, to treat flocks of chickens with fatal respiratory disease caused by infectious bacteria. CVM's concern was that fluoroquinolones are also used in human medicine, raising the possibility that fluoroquinolone-resistant strains of bacteria selected by use of fluoroquinolones in chickens might infect humans and then prove resistant to treatment with human medicines in the same class of antibiotics, such as ciprofloxacin. As a foundation for its risk assessment model, CVM proposed a dramatically simple approach that skipped many of the steps in traditional risk assessment. The basic idea was to assume that human health risks were directly proportional to some suitably defined exposure metric. In symbols: Risk = K Exposure, where "Exposure" would be defined in terms of a metric such as total production of chicken contaminated with fluoroquinolone-resistant bacteria that might cause human illnesses, and "Risk" would describe the expected number of cases per year of human illness due to fluoroquinolone-resistant bacterial infections caused by chicken and treated with fluoroquinolones.
Автор: Fred E. Hahn Название: Mechanism of Action of Antibacterial Agents ISBN: 364246405X ISBN-13(EAN): 9783642464058 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first volume of Antibiotics was published in 1967 and contained a series of review papers on antibiotic actions.
Автор: Li Название: Polymyxin Antibiotics: From Laboratory Bench to Bedside ISBN: 3030163717 ISBN-13(EAN): 9783030163716 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’.
Автор: Wilson Mary E. Название: Antibiotics: What Everyone Needs to Know(r) ISBN: 0190663405 ISBN-13(EAN): 9780190663407 Издательство: Oxford Academ Рейтинг: Цена: 1944.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Virtually everyone has taken antibiotics. They can be lifesavers -- or they can be useless. But what are they? How are they used? And what happens as the effectiveness of antibiotics begins to decline?
Автор: Omura, Satoshi Название: Macrolide Antibiotics ISBN: 0125264518 ISBN-13(EAN): 9780125264518 Издательство: Elsevier Science Рейтинг: Цена: 20380.00 р. Наличие на складе: Нет в наличии.
Описание: Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the
Автор: Srivastava Название: Health Effects of Pesticides ISBN: 0367175185 ISBN-13(EAN): 9780367175184 Издательство: Taylor&Francis Рейтинг: Цена: 23734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Health Effects of Pesticides covers various aspects of the use of pesticides, their behaviour, degradation, and impacts on the agrarian environment. It focuses on pesticide poisoning incidents and farm practices in developing countries. The health impacts of pesticides, including neurological, respiratory, and dermal effects, are examined. Other repercussions caused as a result of pesticides, including reproductive abnormalities and cancer, are comprehensively discussed. Effects of pesticides on general health and agrarian health surveys have been touched upon. Please note: This volume is Co-published with The Energy and Resources Institute Press, New Delhi. Taylor & Francis does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka
Автор: Jacobson Название: Focus On Phytochemical Pesticides ISBN: 1315892952 ISBN-13(EAN): 9781315892955 Издательство: Taylor&Francis Рейтинг: Цена: 15310.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: First published in 1989. Presents research and findings from a series of conferences in the 1980s on the use of plants in pesticides for insect control.
While current methods used in ecological risk assessments for pesticides are largely deterministic, probabilistic methods that aim to quantify variability and uncertainty in exposure and effects are attracting growing interest from industries and governments. Probabilistic methods offer more realistic and meaningful estimates of risk and hence, potentially, a better basis for decision-making. Application of Uncertainty Analysis to Ecological Risks of Pesticides examines the applicability of probabilistic methods for ecological risk assessment for pesticides and explores their appropriateness for general use.
The book presents specific methods leading to probabilistic decisions concerning the registration and application of pesticides and includes case studies illustrating the application of statistical methods. The authors discuss Bayesian inference, first-order error analysis, first-order (non-hierarchical) Monte Carlo methods, second-order Bayesian and Monte Carlo methods, interval analysis, and probability bounds analysis. They then examine how these methods can be used in assessments for other environmental stressors and contaminants.
There are many methods of analyzing variability and uncertainty and many ways of presenting the results. Inappropriate use of these methods leads to misleading results, and experts differ on what is appropriate. Disagreement about which methods are appropriate will result in wasted resources, conflict over findings, and reduced credibility with decision makers and the public. There is, therefore, a need to reach a consensus on how to choose and use appropriate methods, and to present this in the form of guidance for prospective users. Written in a clear and concise style, the book examines how to use probabilistic methods within a risk-based decision paradigm.
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