Описание: This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
Автор: Walmor C. DeMello; Edward D. Frohlich Название: Renin Angiotensin System and Cardiovascular Disease ISBN: 1607611856 ISBN-13(EAN): 9781607611851 Издательство: Springer Рейтинг: Цена: 26711.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Covers aspects such as intracellular signaling, regulation of cell volume in the failing heart, the presence of an intracrine renin angiotensin system, and the influence of prorenin/renin, angiotensin II, angiotensin (1-7) and aldosterone. This book offers a review of the topics involving the renin angiotensin system and cardiovascular disease.
Автор: Dhalla Название: The Renin Angiotensin System in Cardiovascular Disease ISBN: 3031149513 ISBN-13(EAN): 9783031149511 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
Автор: Li, Xiao C Zhuo, Jia L Название: Renin-angiotensin system and the kidney ISBN: 1615046747 ISBN-13(EAN): 9781615046744 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 4712.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in health and disease. The RAS has remarkably evolved from the initial discovery of the rate-limiting enzyme renin to a complex biochemical and physiological cascade involving more than a dozen members. Currently, there are up to five axes or pathways identified in the RAS; each has its substrate, enzyme, effector peptide, receptor, and downstream signaling pathways. These include the renin/ACE/ANG II/AT1 receptor, the APA/ANG III/AT2 receptor, the ACE2/ANG (1-7)/Mas receptor, the prorenin/prorenin receptor (PRR), and the ANG IV/AT4 receptor (IRAP) pathways. Accordingly, the roles of the RAS have expanded well beyond the classic endocrine paradigm as a powerful vasoconstrictor, a potent aldosterone stimulator, or a sodium-retaining hormonal system. The goals of this article are to review and discuss the current insights into and new perspectives on the expression, localization, and novel actions of the RAS with a focus in the kidney. Special emphasis will be placed on recently discovered new members of the RAS derived from studies using innovative mutant rats or mice that either overexpress (knockin) or are deficient (knockout) of a particular substrate, enzyme, ANG peptide, or receptor. This new knowledge will help improve our understanding how each of these pathways act directly or indirectly to regulate blood pressure, cardiovascular and kidney function in physiology, and can be targeted to treat hypertension, cardiovascular and renal diseases.
Автор: Sean E. Thatcher Название: The Renin-Angiotensin-Aldosterone System ISBN: 1493970283 ISBN-13(EAN): 9781493970285 Издательство: Springer Рейтинг: Цена: 17074.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Discussing protocols in measuring components in the renin-angiotensin-aldosterone system (RAAS), this book also looks at methods to assess angiotensin peptides and the influence of RAAS components on mammalian diseases. In the Methods in Molecular Biology series, it lists the necessary materials in step-by-step, reproducible laboratory protocols.
Описание: The special issue of Molecular and Cellular Biochemistry focuses on `Control of Gene Expression by Catecholamines and the Renin-Angiotensin System` in health and disease. This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II.
Автор: D. Ganten; M.P. Printz; M.I. Phillips; B.A. Sch?lk Название: The Renin Angiotensin System in the Brain ISBN: 3642464580 ISBN-13(EAN): 9783642464584 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first publications on the presence of renin, angiotensino- gen and angiotensin-like material in brain tissue appeared about ten years ago. This coincided with the discovery of new biological actions of angiotensin in the brain and with the reinvestigation of already known central angiotensin effects. The possibility that angiotensin could be generated within the brain itself had therefore exciting implications. With the recent popularity of brain neuropeptides, interest in this area is even increasing. The discovery of renin-like activity as well as angiotensino- gen and angiotensin in the brain has led, admittedly by inductive inference, to the hypothesis of the existence of a complete endogenous renin-angiotensin system in the brain.1 For several years there was ardent discussion whether such a renin angiotensin system existed in the brain or not. Inductive inference always contains "an irrational element or a creative intuition".2In view of the biological relevance of a brain angiotensin system, deductive testing of the hypothesis was a worthwhile scientific project taken up by a number of investigators As a matter of principle it is not given to science, to reach either truth or falsity, scientific statements can only attain contmous degrees of probability whose unat- tamable upper and lower limits are truth or falsity. However, several of the early singular statements and results turned out to be reproducible and acceptable. The theory has thus so far passed its test and we have found no reason to discard it.
Описание: Preface... Table of Contents... Contributing Authors...
1. A Brief Introduction into the Renin-Angiotensin-Aldosterone System: New and Old Techniques Sean E. Thatcher
2. A Color Segmentation Based Method to Quantify Atherosclerotic Lesion Compositions with Immunostaining Congqing Wu, Alan Daugherty, and Hong Lu 3. Assessment of Protein Carbonylation and Protein Tyrosine Phosphatase (PTP) Oxidation in Vascular Smooth Muscle Cells (VSMCs) using Immunoblotting Approaches Sofia Tsiropoulou and Rhian M. Touyz 4. Methods for Studying the Role of RAAS in the Modulation of Vascular Repair-Relevant Functions of Stem/Progenitor Cells Yagna P.R. Jarajapu 5. Use of a Fluorescent Substrate to Measure ACE2 Activity in the Mouse Abdominal Aorta Yu Wang, Lisa A. Cassis, and Sean E. Thatcher 6. Measuring Blood Pressure using a Non-Invasive Tail Cuff Method in Mice Yu Wang, Sean E. Thatcher, and Lisa A. Cassis 7. Blood Pressure Monitoring using Radio Telemetry Method in Mice Yu Wang, Sean E. Thatcher, and Lisa A. Cassis 8. Characterization and Functional Phenotyping of Renal Immune Cells via Flow Cytometry Nathan P. Rudemiller and Steven D. Crowley 9. Assessment of the Renin-Angiotensin System in Cellular Organelle: New Arenas for Study in the Mitochondria Bryan A. Wilson and Mark C. Chappell 10. Comprehensive Assessments of Energy Balance in Mice Justin L. Grobe 11. In Vitro Assays to Determine Smooth Muscle Cell Hypertrophy, Protein Content, and Fibrosis Katherine J. Elliott and Satoru Eguchi 12. A New Mouse Model for Introduction of Aortic Aneurysm by Implantation of Deoxycorticosterone Acetate Pellets or Aldosterone Infusion in the Presence of High Salt Shu Liu, Ming C. Gong, and Zhenheng Guo 13. Fluorescence-Based Binding Assay for Screening Ligands of Angiotensin Receptors Maiia E. Bragina, Nikolaos Stergiopulos, and Rodrigo A. Fraga-Silva 14. A Primer to Angiotensin Peptide Isolation, Stability, and Analysis by Nano-Liquid Chromatography with Mass Detection Mariola Olkowicz, Stefan Chlopicki, and Ryszard T. Smolenski 15. Analysis of Angiotensin Metabolism in the Kidney using Mass Spectrometry Nadja Grobe and Khalid M. Elased
Автор: J. Alan Johnson Название: The Renin-Angiotensin System ISBN: 1461591759 ISBN-13(EAN): 9781461591757 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Hideshi Kobayashi; Yoshio Takei Название: The Renin-Angiotensin System ISBN: 3642647251 ISBN-13(EAN): 9783642647253 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of verte- brates, along with many other systems involved in the in- tegrated survival of the organism.
Автор: Walmor C. DeMello; Edward D. Frohlich Название: Renin Angiotensin System and Cardiovascular Disease ISBN: 1617796387 ISBN-13(EAN): 9781617796388 Издательство: Springer Цена: 26711.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Systemic Versus Local Renin Angiotensin Systems: An Overview Walmor C De Mello, MD and Richard N Re, MD Clinical Importance of the Local Renin-Angiotensin aldosterone Systems Edward D. Frohlich, MD Renin, Prorenin And The (Pro)Renin Receptor Genevieve Nguyen and Aurelie Contrepas Local Renin-Angiotensin Systems in the Cardiovascular System Richard N Re, MD Renin-Angiotensin-Aldosterone System and Pathobiology of Hypertension Pierre Paradis, MD and Ernesto L. Schiffrin, MD At1 Receptors, Angiotensin Receptor Blockade and Clinical Hypertensive Disease Robert M. Carey, M.D., M.A.C. P Structural and Electrophysiologic Remodeling of the Failing Heart. On the Role of the Renin Angiotensin Aldosterone System Walmor C De Mello, MD Inhibiting the Renin Angiotensin Aldosterone System in Patients with Heart Failure and Myocardial Infarction Marc A. Pfeffer, M.D., Ph.D Left Ventricular Hypertrophy and Treatment With Renin-Angiotensin System Inhibition Edward D. Frohlich, MD and Javier Dнez, MD, PhD Angiotensin-(1-7), Angiotensin Converting Enzyme 2, and New Components of the Renin-Angiotensin System Aaron J. Trask, Jasmina Varagic, Sarfaraz Ahmad, Carlos M. Ferrario Kinin Receptors and ACE Inhibitors: an Interrelationship Ervin G. Erdцs, MD, Fulong Tan, PhD and Randal A. Skidgel, PhD Kinins and Cardiovascular Disease Oscar A. Carretero, M.D., Xiao-Ping Yang, MD, Nour-Eddine Rhaleb, PhD, FAHA CMS and Type 2 diabetes Mellitus: Bound together by the Renin-Angiotensin-Aldosterone System Deepashree Gupta, MD, Guido Lastra, MD, Camila Manrique, MD, James R Sowers, MD Renin Angiotensin Aldosterone System and CardiovascularDisease Swynghedauw Bernard, Milliez Paul, Messaoudi Smail, Benard Ludovic, Samuel Jane-Lise, Delcayre Claude Renin Angiotensin System and Atherosclerosis Changping Hu, Jawahar L. Mehta Renin Angiotensin System and Aging Leуn F. Ferder MD
Описание: Highlighting the role local renin-angiotensin systems (RAS) play in pancreatic disease, this review presents the latest research advances in the field. These findings suggest both preventative measures and treatment for pancreatic disease.
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