In Vivo MR Techniques in Drug Discovery and Development, Beckman, Nicolau
Автор: Wood Clive R Название: Antibody Drug Discovery ISBN: 1848166281 ISBN-13(EAN): 9781848166288 Издательство: World Scientific Publishing Рейтинг: Цена: 24552.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. This title offers guidance to those evaluating and preparing to enter particular areas within the field.
Автор: Li Название: The Drug Discovery Experience: Practices, Processes, and Perspectives ISBN: 0470942355 ISBN-13(EAN): 9780470942352 Издательство: Wiley Рейтинг: Цена: 12302.00 р. 17574.00-30% Наличие на складе: Есть (1 шт.) Описание: Edited by two distinguished chemists from academia and industry, this book presents an up-to-date overview of major aspects of drug discovery. It covers all ends of the discovery process from target selection to major therapeutic areas.
Автор: Caffrey Название: Parasitic Helminths: Targets, Screens, Drugs and Vaccines ISBN: 3527330593 ISBN-13(EAN): 9783527330591 Издательство: Wiley Рейтинг: Цена: 12856.00 р. 18366.00-30% Наличие на складе: Есть (1 шт.) Описание: The first title dealing with drug discovery against parasitic worms (Helminths) which include many of the major human and animal parasites. The book focusses on the development of novel drugs and vaccination strategies making it attractive for academia and industry alike.
Автор: Lamprou Название: Nano- and Microfabrication Techniques in Drug Delivery ISBN: 3031269071 ISBN-13(EAN): 9783031269073 Издательство: Springer Рейтинг: Цена: 28051.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New materials and manufacturing techniques are evolving with the potential to address the challenges associated with the manufacture of medicinal products that will teach new tricks to old drugs. Nano- and microfabrication techniques include manufacturing methods such as additive manufacturing, lithography, micro-moulding, spray drying, and supercritical fluids among many others. The increasing resolution of new techniques allow researchers to produce objects with micrometric resolutions. This book follows a consecutive order, beginning with a background in the current field and limitations in the manufacturing of different pharmaceutical products, moving on the classification of each method by providing recent examples, and future prospective on a variety of traditional and new Nano and microfabrication techniques. A focus on the materials used to prepare these systems and their biocompatibility, including applied topics such as clinical applications and regulatory aspects also covered, offering the reader a holistic view of this rapidly growing field.
For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing preferred gas and liquid chromatographic methods, Advances in Chromatographic Techniques for Therapeutic Drug Monitoring is a comprehensive reference describing the theory and application of therapeutic drug monitoring in clinical laboratories.
Edited by a distinguished authority in the field and containing contributions from a variety of experts, the book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and therapeutic drug monitoring for a range of medications, including:
Anticonvulsants
Digitalis
Cardioactive drugs
Antidepressants
Immunosuppressants
Anti-cancer drugs
Vancomycin and aminoglycosides
Antibiotics
Antiretroviral drugs
Nonnarcotic analgesics
Anti-inflammatory drugs
Examing older and newer drugs, the book contains detailed discussions on the rationale for therapeutic drug monitoring of each class of drugs, along with their basic pharmacology and toxicology. An extensive list of references is provided at the end of each chapter so that those interested in implementing a new drug assay can find the most appropriate method for the intended drug.
Автор: Jackson, Robert C. Название: Computer Techniques in Preclinical and Clinical Drug Development ISBN: 0367401282 ISBN-13(EAN): 9780367401283 Издательство: Taylor&Francis Рейтинг: Цена: 10411.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.
Описание: Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and the bench with information needed to accelerate clinically-effective CNS drug discovery.
Автор: Vela Название: In Vivo Models for Drug Discovery ISBN: 3527333282 ISBN-13(EAN): 9783527333288 Издательство: Wiley Рейтинг: Цена: 23118.00 р. Наличие на складе: Поставка под заказ.
Описание: This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transde
Название: Pharmaceutical Product Development ISBN: 0367453177 ISBN-13(EAN): 9780367453176 Издательство: Taylor&Francis Рейтинг: Цена: 10104.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During the last two decades, the pharmaceutical industry has been under pressure to reduce development costs and the time needed to bring drugs to market in order to maximize return on investment and bring treatments to patients sooner. To meet these ends, pharmaceutical scientists working in the differing areas of pharmacy, pharmaceutics, and pharmacokinetics are collaborating to address physicochemical and biological issues in the early stages of development to avoid problems in later stages. In Vitro-In Vivo Correlation (IVIVC) is a multidisciplinary tool that has been successfully applied in testing the effectiveness of a drug substance. The only comprehensive guide available on IVIVC, this source illustrates the emerging importance of IVIVC in the drug development process, and covers the most recent advances and regulatory perspectives on the role of IVIVC in the pharmaceutical industry.
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