Membrane Structure in Disease and Drug Therapy, Cornell, Svante
Автор: Kumar Vinay Название: Robbins And Cotran Pathologic Basis Of Disease, 10 ed. IE ISBN: 0323609929 ISBN-13(EAN): 9780323609920 Издательство: Elsevier Science Рейтинг: Цена: 9725.00 р. Наличие на складе: Заказано в издательстве.
Описание: Readable and highly illustrated, Robbins and Cotran Pathologic Basis of Disease, 10th Edition presents an in-depth, state-of-the-art overview of human diseases and their cellular and molecular basis. This best-selling text delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content. More than 1,000 high-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more.
This superb learning package also includes an enhanced eBook with a full complement of ancillary content on Student Consult.
Автор: David S Strayer Название: Rubins Pathology 8 Ed. IE. ISBN: 1975141024 ISBN-13(EAN): 9781975141028 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 16998.00 р. Наличие на складе: Есть (4 шт.) Описание: Learn how to sail the world`s most popular junior sailing boat fast. Originally written by Ben Ainslie`s Optimist coach, this new edition has been completely updated by top coach Steve Irish. It shows how to achieve blistering boatspeed through technique and tuning, perfect boat handling and tactics as well as covering the mental and physical side.
Автор: Vinay Kumar, Abul K. Abbas, Jon C. Aster Название: Robbins & Cotran Pathologic Basis Of Disease 10 ed. ISBN: 032353113X ISBN-13(EAN): 9780323531139 Издательство: Elsevier Science Рейтинг: Цена: 16673.00 р. Наличие на складе: Есть (1 шт.) Описание: Readable and highly illustrated, Robbins and Cotran Pathologic Basis of Disease, 10th Edition presents an in-depth, state-of-the-art overview of human diseases and their cellular and molecular basis. This best-selling text delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content. More than 1,000 high-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. This superb learning package also includes an enhanced eBook with a full complement of ancillary content on Student Consult.
Provides uniquely authoritative and readable coverage, ideal for USMLE or specialty board preparation, as well as for coursework.
Covers the hot topics you need to know about, including novel therapies for hepatitis C, classification of lymphomas, unfolded protein response, non-apoptotic pathways of cell death, coronavirus infections, liquid biopsy for cancer detection, regulation of iron absorption, clonal hematopoiesis and atherosclerosis, thrombotic microangiopathies, heparin-induced thrombocytopenias, inflammatory myopathies, genetic tools for treatment of cystic fibrosis, and many more.
Uses an outstanding full-color, user-friendly design to simplify your study and quickly direct you to the information you need to know, with learning features such as boldface overviews at the beginning of each section, key concepts boxes, suggested readings, schematic diagrams that illustrate complex concepts, and new gross and microscopic figures for clarity of morphology.
Brings you up to date with the latest information in molecular and genetic testing, mechanisms of disease, personalized medicine and its impact on treatment of human diseases, the role of microbiome and metabolome in non-communicable diseases, and much more.
Provides access to a wealth of interactive ancillaries online: pathology case studies, videos, self-assessment questions, Targeted Therapy boxes that discuss drug therapy for specific diseases, interactive cases, and more.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
Автор: Abbas, Abul K. Fausto, Nelson Kumar, Vinay Название: Robbins and Cotran Pathologic Basis of Disease.-9 ed. ISBN: 0808924508 ISBN-13(EAN): 9780808924500 Издательство: Elsevier Science Рейтинг: Цена: 9136.00 р. Наличие на складе: Нет в наличии.
Описание: Ashton B. Carter said when announcing that the Pentagon would open all combat jobs to women, "I made a commitment to building America`s force of the future. In the twenty-first century, that requires drawing strength from the broadest possible pool of talent." William Taylor chronicles and analyses the long and ever-changing history of that often contentious and controversial effort.
Описание: Enthusiastically acclaimed by medical students and faculty worldwide, this text is specifically designed to prepare students for their first encounters with patients with cardiovascular disease. Thoroughly revised by internationally recognized Harvard Medical School faculty and a team of select cardiology fellows and internal medicine residents, this seventh edition equips students with a clear, complete, and clinically relevant understanding of cardiovascular pathophysiology, setting a strong foundation for patient diagnosis and management. New seventh edition highlights:Review questions and answers in each chapter prepare students for course and board exams.
New contributors include cardiology fellows and internal medicine residents, who worked closely with faculty to extend coverage of clinically pertinent issues for medical students. Updated content reflects the latest understanding of mechanisms of cardiac disease and technological advances. Classic student-friendly features:Full-color illustrations help readers visualize and quickly grasp key concepts.
Medical imaging and color clinical photographs show real-world examples of many clinically relevant cardiovascular conditions. Introductory chapter outlines and end-of-chapter summaries provide organized, quick review of core information. Bonus online study tools:Animations help support understanding of complex, dynamic disease processes.
Interactive question bank reinforces learning and improves retention.
Автор: Sajal Chakraborti; Naranjan S Dhalla Название: Regulation of Membrane Na+-K+ ATPase ISBN: 3319247484 ISBN-13(EAN): 9783319247489 Издательство: Springer Рейтинг: Цена: 24392.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s ?- and ?- subunits. At present four different ?- (?-1,?-2,?-3 and ?-4) and three ?- (?-1, ?-2, and ?-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of ?- and ?- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of ?-? subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.
Автор: Murphy, Sean V. Название: Regenerative Medicine Technology ISBN: 0367658267 ISBN-13(EAN): 9780367658267 Издательство: Taylor&Francis Рейтинг: Цена: 7808.00 р. Наличие на складе: Нет в наличии.
Автор: Christer Larsson; Ian M. Moller Название: The Plant Plasma Membrane ISBN: 3642745245 ISBN-13(EAN): 9783642745249 Издательство: Springer Рейтинг: Цена: 13677.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The plasma membrane forms the living barrier between the cell and its surroundings. The first isolation of plant protoplasts by enzymatic digestion of the cell wall in the early 1970`s was an important step forward in that it provided direct access to the outer surface of the plasma membrane.
Автор: Reinhard Kr?mer; Christine Ziegler Название: Membrane Transport Mechanism ISBN: 3662523051 ISBN-13(EAN): 9783662523056 Издательство: Springer Рейтинг: Цена: 17096.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane.
Автор: Jean-Jacques Lacap?re Название: Membrane Protein Structure Determination ISBN: 1493961179 ISBN-13(EAN): 9781493961177 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part I: Membrane Protein Purification 1. Characterization of Membrane Protein Preparations: Measurement of Detergent Content and Ligand Binding after Proteoliposomes Reconstitution Mariano A. Ostuni, Soria Iatmanen, David Teboul, Jean-Claude Robert, and Jean-Jacques Lacapиre 2. Native Membrane Proteins Versus Yeast Recombinant: An Example, the Mitochondrial ADP/ATP Carrier Bertrand Arnou, Cйcile Dahout-Gonzalez, Ludovic Pelosi, Guy J.-M. Lauquin, Gйrard Brandolin, and Vйronique Trйzйguet 3. Bacterial Overexpressed Membrane Proteins: An Example, the TSPO Jean-Claude Robert and Jean-Jacques Lacapиre 4. Insect Cell Versus Bacterial Overexpressed Membrane Proteins: An Example, the Human ABCG2 Transporter Alexandre Pozza, Josй M. Perez-Victoria, and Attilio Di Pietro Part II: X-Ray Crystallography 5. Crystallography of Membrane Proteins: From Crystallization to Structure Aurйlien Deniaud, Ekaterina Moiseeva, Valentin Gordeliy, and Eva Pebay-Peyroula 6. Structural Approaches of the Mitochondrial Carrier Family Hughes Nury, Iulia Blesneac, Stephanie Ravaud, and Eva Pebay-Peyroula 7. What Can Be Learned about the Function of a Single Protein from Its Various X-Ray Structures: The Example of the Sarcoplasmic Calcium Pump Jesper Vuust M ller, Claus Olesen, Anne-Marie Lund Winther, and Poul Nissen 8. Toward Drug Design: Recent Progress in the Structure of GPCR, a Membrane Protein with High Potential as a Pharmaceutical Target Vadim Cherezov, Enrique Abola, and Raymond C. Stevens Part III: Electron Microscopy 9. Observation of Membrane Proteins in situ: AQPcic, the Insect Aquaporin Example Daniel Thomas and Annie Cavalier 10. Two-Dimensional Crystallization of Integral Membrane Proteins for Electron Crystallography David L. Stokes, William J. Rice, Minghui Hu, Changki Kim, and Iban Ubarretxena 11. Structure Determination of Membrane Protein by Both Cryo Electron Tomography and Single Particle Analysis Sylvain Trйpout, Jean-Christophe Taveau, and Olivier Lambert 12. Electron Microscope Tomography of Native Membranes Gabriel Pйranzi, Cedric Messaoudi, Leeyah Issop, and Jean-Jacques Lacapиre 13. From Electron Microscopy Maps to Atomic Structures Using Normal Mode-Based Fitting Konrad Hinsen, Edward Beaumont, Bertrand Fournier, and Jean-Jacques Lacapиre Part IV: Nuclear Magnetic Resonance 14. Determination of Membrane Protein Structures Using Solution and Solid-State NMR Pierre Montaville and Nadиge Jamin 15. Membrane Protein Fragments Reveal Both Secondary and Tertiary Structure of Membrane Proteins Philip L. Yeagle and Arlene D. Albert 16. What Can We Learn From a Small Regulatory Membrane Protein? Gianluigi Veglia, Kim N. Ha, Lei Shi, Raffaello Verardi, and Nathaniel J. Traaseth 17. Solution-State NMR Spectroscopy for Investigating 3D Structure of Membrane Proteins in Detergent Micelles: Structure of the Klebsiella pneumoniae Outer Membrane Protein, KpOmpA Marie Renault, Olivier Saurel, Pascal Demange, Virginie Reat, and Alain Milon 18. NMR Spectroscopy of Lipid Bilayers Axelle Grйlard, Cйcile Loudet, Anna Diller, and Erick J. Dufourc Part V: Molecular Modelling 19. Critical Review of General Guidelines for Membrane Proteins Model Building and Analysis Catherine Etchebest and Gaelle Debret 20. 3D-Structural Models of Transmembrane Proteins Alexandre G. de Brevern 21. Molecular Dynamics of Membrane Peptides and Proteins: Principles and Comparison to Experimental Data Patrick F.J. Fuchs 22. Membrane Protein Dynamics from Femtoseconds to Seconds Christian Kandt and Luca Monticelli 23. The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins Irina G. Tikhonova and Daniel Fourmy
Автор: E. Anibal Disalvo Название: Membrane Hydration ISBN: 3319346644 ISBN-13(EAN): 9783319346649 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is about the importance of water in determining the structure, stability and responsive behavior of biological membranes. Water confers to lipid membranes unique features in terms of surface and mechanical properties. The analysis of the hydration forces, plasticiser effects, controlled hydration, formation of microdomains of confined water suggests that water is an active constituent in a water-lipid system. The chapters describe water organization at the lipid membrane–water interphase, the water penetration, the long range water structure in the presence of lipid membranes by means of X-ray and neutron scattering, general polarization, fluorescent probes, ATR-FTIR and near infrared spectroscopies, piezo electric methods, computer simulation and surface thermodynamics. Permeation, percolation, osmotic stress, polarization, protrusion, sorption, hydrophobicity, density fluctuations are treated in detail in self-assembled bilayers. Studies in lipid monolayers show the correlation of surface pressure with water activity and its role in peptide and enzyme interactions. The book concludes with a discussion on anhydrobiosis and the effect of water replacement in microdomains and its consequence for cell function. New definitions of lipid/water interphases consider water not only as a structural-making solvent but as a mediator in signalling metabolic activity, modulating protein insertion and enzymatic activity, triggering oscillatory reactions and functioning of membrane bound receptors. Since these effects occur at the molecular level, membrane hydration appears fundamental to understand the behavior of nano systems and confined environments mimicking biological systems. These insights in structural, thermodynamical and mechanical water properties give a base for new paradigms in membrane structure and function for those interested in biophysics, physical chemistry, biology, bio and nano medicine, biochemistry, biotechnology and nano sciences searching for biotechnological inputs in human health, food industry, plant growing and energy conversion.
Автор: Nagarajan Vaidehi; Judith Klein-Seetharaman Название: Membrane Protein Structure and Dynamics ISBN: 1493962337 ISBN-13(EAN): 9781493962334 Издательство: Springer Рейтинг: Цена: 17684.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book details approaches to the structure, dynamics and interactions of membrane proteins, including measurement procedures and computational methods for structure prediction and insight on the dynamics of membrane receptors.
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