This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Описание: This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.
Автор: Smith, Moyra (division Of Genetic And Genomic Medicine, Department Of Pediatrics, University Of California Irvine, Irvine, Ca, United States) Название: Mechanisms and genetics of neurodevelopmental cognitive disorders ISBN: 0128219130 ISBN-13(EAN): 9780128219133 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases.
This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.
Описание: This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.
Автор: Jos? Mar?a Frade; Fred H. Gage Название: Genomic Mosaicism in Neurons and Other Cell Types ISBN: 1493972790 ISBN-13(EAN): 9781493972791 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuromethods Series Preface... Preface... Table of Contents... Contributing Authors...
Part I Introduction
1. Principles and Approaches for Discovery and Validation of Somatic Mosaicism in the Human Brain Alexej Abyzov, Alexander E. Urban, and Flora M. Vaccarino
Part II Aneuploidy and Ploidy Variation
2. FISH-Based Assays for Detecting Genomic (Chromosomal) Mosaicism in Human Brain Cells Yuri B. Yurov, Svetlana G. Vorsanova, Ilia V. Soloviev, Alexei M. Ratnikov, and Ivan Y. Iourov
3. Flow Cytometric and Sorting Analyses for Nuclear DNA Content, Nucleotide Sequencing and Interphase FISH Gwendolyn E. Kaeser and Jerold Chun
4. Flow Cytometric Quantification, Isolation, and Subsequent Epigenetic Analysis of Tetraploid Neurons Noelia Lуpez-Sбnchez, Iris Patiсo-Parrado, and Josй M. Frade
5. A Cytomic Approach towards Genomic Individuality of Neurons Thomas Arendt, Birgit Belter, Martina K. Brьckner, Uwe Ueberham, Markus Morawski, and Attila Tarnok
Part III DNA Copy Number Variation
6. Single Cell CNV Detection in Human Neuronal Nuclei Margaret B. Wierman, Ian E. Burbulis, William D. Chronister, Stefan Bekiranov, and Michael J. McConnell
7. Multiple Annealing and Looping-Based Amplification Cycles (MALBAC) for the Analysis of DNA Copy Number Variation Chenghang Zong
8. Competitive PCR for Copy Number Assessment by Restricting dNTPs Luming Zhou, Robert A. Palais, Yotam Ardon, and Carl T. Wittwer
9. Using Cloning to Amplify Neuronal Genomes for Whole Genome Sequencing and Comprehensive Mutation Detection and Validation Jennifer L. Hazen, Michael A. Duran, Ryan P. Smith, Alberto R, Rodriguez, Greg S. Martin, Sergey Kupriyanov, Ira M. Hall, and Kristin K. Baldwin
Part IV LINE-1 Retrotransposition
10. Analysis of LINE-1 Retrotransposition in Neural Progenitor Cells and Neurons Angela Macia and Alysson R. Muotri
11. Estimation of LINE-1 Copy Number in the Brain Tissue and Isolated Neuronal Nuclei Miki Bundo, Tadafumi Kato, and Kazuya Iwamoto
12. Analysis of Somatic LINE-1 Insertions in Neurons Francisco J. Sanchez-Luque, Sandra R. Richardson, and Geoffrey J. Faulkner
13. Single-Cell Whole Genome Amplification and Sequencing to Study Neuronal Mosaicism and Diversity Patrick J. Reed, Meiyan Wang, Jennifer A. Erwin, Apuг C.M. Paquola, and Fred H. Gage
Part V Genetic and Genomic Mosaicism in Aging and Disease
14. FISH Analysis of Aging-Associated Aneuploidy in Neurons and Non-Neuronal Brain Cells Grasiella A. Andriani and Cristina Montagna
15. Genomic Analysis and In Vivo Functional Validation of Brain Somatic Mutations Leading to Focal Cortical Malformations Jae Seok Lim and Jeong Ho Lee
16. Using Fluorescence In Situ Hybridization (FISH) Analysis to Measure Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative Diseases Julbert Caneus, Antoneta Granic, Heidi J. Chial, Huntington Potter
17. Identification of Low Allele Frequency Mosaic Mutations in Alzheimer Disease Carlo Sala Frigerio, Mark Fiers, Thierry Voet, and Bart De Strooper
Автор: Rex A. Dwyer Название: Genomic Perl ISBN: 052180177X ISBN-13(EAN): 9780521801775 Издательство: Cambridge Academ Цена: 7445.00 р. Наличие на складе: Поставка под заказ.
Описание: This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
Автор: Rolf Ohlsson Название: Genomic Imprinting ISBN: 3662219565 ISBN-13(EAN): 9783662219560 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The form and function of every living organism on the earth depends on the complex regulation of gene expression. This monograph focuses on a particular aspect of the epigenetic control of gene function: genomic imprinting.
Автор: Yoshihide Hayashizaki; Sachihiko Watanabe Название: Restriction Landmark Genomic Scanning (RLGS) ISBN: 4431685219 ISBN-13(EAN): 9784431685210 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Cedric Gondro; Julius van der Werf; Ben Hayes Название: Genome-Wide Association Studies and Genomic Prediction ISBN: 1493959646 ISBN-13(EAN): 9781493959648 Издательство: Springer Рейтинг: Цена: 17074.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book covers phenotypes of interest as well as design issues for GWAS, methods for storing and handling large datasets, quality control measures, haplotype inference, and imputation and statistical approaches to data analysis.
Автор: Jos? Mar?a Frade; Fred H. Gage Название: Genomic Mosaicism in Neurons and Other Cell Types ISBN: 1493984403 ISBN-13(EAN): 9781493984404 Издательство: Springer Рейтинг: Цена: 13415.00 р. Наличие на складе: Нет в наличии.
Название: Chromatin and Genomic Instability in Cancer, 364 ISBN: 032385561X ISBN-13(EAN): 9780323855617 Издательство: Elsevier Science Рейтинг: Цена: 31497.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associated DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more.
The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology.
Автор: Kovas Yulia, Selita Fatos Название: Oedipus Rex in the Genomic Era: Human Behaviour, Law and Society ISBN: 1349960470 ISBN-13(EAN): 9781349960477 Издательство: Springer Рейтинг: Цена: 13415.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explores the answers to fundamental questions about the human mind and human behaviour with the help of two ancient texts.
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