Автор: Parre?o, Viviana Название: The Guinea Pig Model ISBN: 1032446404 ISBN-13(EAN): 9781032446400 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Нет в наличии.
Описание: This book summarizes the development and statistical validation of a guinea pig model as an alternative for potency testing of the viral antigens included in combined vaccines applied in cattle to control the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows, in one serum sample, to test the vaccine quality for all the viral antigens included in aqueous as well as in oil-adjuvanted formulations of bovine vaccines. The methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus were recommended by CAMEVET as guidelines for the 30 countries in the forum, including the US.
Key FeaturesReviews combined vaccines used for cattleSummarizes animal models used for vaccine testingFocuses on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virusProvides guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicity
Название: Nanoparticulate vaccine delivery systems ISBN: 9814613304 ISBN-13(EAN): 9789814613309 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyer's patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyer's patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer.
Автор: Pfeifer Blaine A., Hill Andrew Название: Vaccine Delivery Technology: Methods and Protocols ISBN: 1071607944 ISBN-13(EAN): 9781071607947 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses the vaccine development process and the role delivery concepts contribute to a global goal of effective health outcomes.
Автор: Camilla Foged; Thomas Rades; Yvonne Perrie; Sarah Название: Subunit Vaccine Delivery ISBN: 1493914162 ISBN-13(EAN): 9781493914166 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.
Автор: Camilla Foged; Thomas Rades; Yvonne Perrie; Sarah Название: Subunit Vaccine Delivery ISBN: 1493948512 ISBN-13(EAN): 9781493948512 Издательство: Springer Рейтинг: Цена: 17096.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
.- 1 Immunological Background
.- 2 Classification of Vaccines
.- 3 Aluminum Adjuvants - Basic Concepts and Progress in Understanding
.- 4 Emulsions as Vaccine Adjuvants
.- 5 The application of liposomes as vaccine adjuvants
.- 6 Developing Bilayer-based Delivery Systems for Oral Delivery of Subunit Vaccines
.- 7 Cubosomes - Structure, Preparation and Use as an Antigen Delivery System
.- 8 ISCOMs as a Vaccine Delivery System
.- 9 Virus-like Particles, a Versatile Subunit Vaccine Platform
.- 10 Polymeric Particulates for Subunit Vaccine Delivery
.- 11 Gels as Vaccine Delivery Systems
.- 12 Implants as Sustained Release Delivery Devices for Vaccine Antigens
.- 13 Dendritic Cell-based Vaccines
.- 14 Parenteral Vaccine Administration - Tried and True
.- 15 Nasal Administration of Vaccines
.- 16 Pulmonary Administration of Subunit Vaccines
.- 17 Vaginal Delivery of Subunit Vaccines
.- 18 Transcutaneous Administration
.- 19 Pharmaceutical Analysis and Quality Control of Vaccines
.- 20 The Physical Analysis of Vaccines
.- 21 Characterizing the Association between Antigens and Adjuvants.
Автор: Madkour, Loutfy H. Название: Nanoparticle-Based Drug Delivery in Cancer Treatment ISBN: 1032135204 ISBN-13(EAN): 9781032135205 Издательство: Taylor&Francis Рейтинг: Цена: 35983.00 р. Наличие на складе: Нет в наличии.
Автор: Sunil Thomas Название: Vaccine Design ISBN: 1493980386 ISBN-13(EAN): 9781493980383 Издательство: Springer Рейтинг: Цена: 20123.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 1: Vaccines for Human Diseases has an introductory section on how vaccines impacted diseases, the immunological mechanism of vaccines, future challenges for vaccinologists, and current trends in vaccinology. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases as well as vaccines for drug abuse, allergy, and tumor vaccines are also described in this volume. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 1: Vaccines for Human Diseases aims to ensure successful results in the further study of this vital field.
Автор: Dushyant Varshney; Manmohan Singh Название: Lyophilized Biologics and Vaccines ISBN: 149392382X ISBN-13(EAN): 9781493923823 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Preface.- Part I - Lyophilization History and Fundamentals.- History of Lyophilization.- Heterogeneity of protein environments in frozen solutions and in the dried state.- Advance understanding of buffer behavior during lyophilization.- Advances in Instrumental Analysis Applied to the Development of Lyophilization Cycles.- New Developments in Controlled Nucleation: Commercializing VERISEQ(R) Nucleation technology.- Part II - Lyophilized Biologics and Vaccines - Modality Considerations.- Lyophilized Biologics.- Lyophilization of Therapeutic Proteins in Vials - Process Scale-up and Advances in Quality by Design.- Advances in Process Analytical Technology in Freeze Drying.- Process Scale-up and Optimization of Lyophilized Vaccine Products.- Stabilization of Plasmid DNA and Lipid-based Therapeutics as Dehydrated Formulations.- Part III - Advances in Alternate Drying.- Alternatives to Vial Lyophilization.- Spray Drying of Biopharmaceuticals.- Current Trends and Advances in Bulk Crystallization and Freeze Drying of Biopharmaceuticals.- Case Studies and Examples of Biopharmaceutical Modalities.- Processed by Bulk Crystallization or Bulk Freeze Drying.- Part IV- Regulatory, Packaging and Technology Transfer Considerations.- Lyophilization of Biologics - An FDA Perspective.- Recent Trends in Lyophilized Delivery Devices and Packaging.- Lyophilization Technology Transfer towards Product Launch.
Автор: Almeida de Sousa Название: DNA Vaccines: Methods and Protocols ISBN: 1071608711 ISBN-13(EAN): 9781071608715 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details practical procedures on the latest DNA vaccine technology. Chapters guide readers through methods and protocols on DNA vaccine design, the adjuvant influence, production and purification methodologies, delivery systems, and approaches of the influence of DNA vaccines in the immunological response performance and in the cancer immunotherapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, DNA Vaccines: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Автор: Thomas Название: Vaccine Design ISBN: 1071618865 ISBN-13(EAN): 9781071618868 Издательство: Springer Рейтинг: Цена: 24392.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a practical guide providing step-by-step protocol to design and develop vaccines for human diseases. Divided into three volumes, Volume 1: Vaccines for Human Diseases guides readers through an introductory section on future challenges for vaccinologists and the immunological mechanism of vaccines. Chapters focus on design of human vaccines for viral, bacterial, fungal, and parasitic diseases as well as tumor vaccines. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 1: Vaccines for Human Diseases aims to be a useful practical guide to researchers to help further their study in this field.
Автор: Sunil Thomas Название: Vaccine Design ISBN: 1493933884 ISBN-13(EAN): 9781493933884 Издательство: Springer Рейтинг: Цена: 26832.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Volume 2: Vaccines for Veterinary Diseases includes vaccines for farm animals and fishes, vaccine vectors and production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation and intellectual property.
Автор: Sunil Thomas Название: Vaccine Design ISBN: 1493980394 ISBN-13(EAN): 9781493980390 Издательство: Springer Рейтинг: Цена: 18904.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 2: Vaccines for Veterinary Diseases includes vaccines for farm animals and fishes, vaccine vectors and production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation and intellectual property. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 2: Vaccines for Veterinary Diseases aims to ensure successful results in the further study of this vital field.
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