Описание: Suitable for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this book discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis.
Автор: A.A. Hadjiolov Название: The Nucleolus and Ribosome Biogenesis ISBN: 3709187443 ISBN-13(EAN): 9783709187449 Издательство: Springer Рейтинг: Цена: 10610.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Jos A.F. Op den Kamp Название: Biological Membranes: Structure, Biogenesis and Dynamics ISBN: 3642788483 ISBN-13(EAN): 9783642788482 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Advanced Study Institute on "Structure, Biogenesis and Dynamics of Biological Membranes, held in Cargese from June 14-26, 1993, has been dealing with four major topics in membrane biochemistry today: lipid dynamics and lipid-protein interactions, protein translocation and insertion, intracellular traffic aud protein structure and folding.
Название: Recombinant Protein Expression: Eukaryotic Hosts, 660 ISBN: 0323907377 ISBN-13(EAN): 9780323907378 Издательство: Elsevier Science Рейтинг: Цена: 26275.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Recombinant Protein Expression, Part B, Volume 660 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on Multiplexed analysis protein: Protein interactions of polypeptides translated in Leishmania cell-free system, MultiBac system and its applications, performance and recent, Production of antibodies in Shuffle, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to enhance transcription in yeast, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to deregulate transcription in yeast, Antibody or protein-based vaccine production in plants, Cell-free protein synthesis, Plant-based expression of biologic drugs, and much more.
Additional sections cover the Use of native mass spectrometry to guide detergent-based rescue of non-native oligomerization by recombinant proteins, Advancing overexpression and purification of recombinant proteins by pilot optimization through tandem affinity-buffer exchange chromatography online with native mass spectrometry, Method for High-Efficiency Fed-batch cultures of recombinant Escherichia coli, Method to transfer Chinese hamster ovary (CHO) shake flask experiments to the ambr(R) 250, and Expression of recombinant antibodies in Leishmania tarentolae.
Автор: Wolfgang Hennig Название: Structure and Function of Eukaryotic Chromosomes ISBN: 3662224380 ISBN-13(EAN): 9783662224380 Издательство: Springer Рейтинг: Цена: 14635.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents an overview of various aspects of chromosome research, written by leading experts of the respective fields, combining classic and recent molecular biological results. The variety and comprehensiveness make it a handbook of chromosome research for all scientists, teachers and graduate students interested in this field. Dieses Buch fa?t die unterschiedlichen Aspekte der Chromosomenforschung in Beitr?gen von f?hrenden Wissenschaftlern zusammen, wobei die klassischen Erkenntnisse mit neuesten Forschungsdaten zu einem umfassenden ?berblick ?ber das Gebiet kombiniert werden.
Автор: Josef A.F. Op den Kamp Название: Dynamics and Biogenesis of Membranes ISBN: 3642741967 ISBN-13(EAN): 9783642741968 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Study Institute on Dynamics and Biogenesis of Membranes held in Cargese, Corsica, June 12-23, 1989
1. Composition and dynamics of the eukaryotic replisome: a brief overview;Stuart A. MacNeill 1.1 Introduction 1.2 Replication origins and the origin recognition complex 1.3 Formation of the pre-RC at origins 1.4 The replisome progression complex 1.5 The replicative polymerases 1.6 Sliding clamp and clamp loader complexes 1.7 Okazaki fragment processing 1.8 Model systems for the studying eukaryotic replication 1.8.1 SV40 1.8.2 Yeast 1.8.3 Xenopus 1.8.4 Archaea 1.8.5 Other model systems 1.9 Conclusions Acknowledgements References
2. Evolutionary diversification of eukaryotic DNA replication machinery; Stephen J. Aves, Yuan Liu and Thomas A. Richards 2.1 Introduction 2.2 Eukaryotic diversity 2.3 Conservation of replisome proteins 2.4 Indispensable replisome proteins 2.5 Replisome proteins present in all eukaryotic supergroups 2.6 Replisome proteins not present in all supergroups 2.7 A complex ancestral replisome 2.8 Conclusions References
3. The origin recognition complex: a biochemical and structural view; Huilin Li and Bruce Stillman 3.1 Introduction 3.2 The S. cerevisiae ORC 3.3 The S. pombe ORC 3.4 The D. melanogaster ORC 3.5 The H. sapiens ORC 3.6 Future perspectives Acknowledgements References
4. Archaeal Orc1/Cdc6 Proteins; Stephen D. Bell 4.1 Introduction 4.2 Origins of DNA replication in the Archaea 4.3 Orc1/Cdc6 Structure 4.4 Structures of Orc1/Cdc6 bound to DNA 4.5 Beyond binding origins - what do Orc1/Cdc6s do?Acknowledgements References
5. Cdt1 and Geminin in DNA replication initiation; Christophe Caillat and Anastassis Perrakis 5.1 Cdt1 and Geminin: a functional preview5.2 The multiple faces of Geminin 5.2.1 Geminin functions in replication licensing 5.2.2 Geminin in the cell cycle 5.2.3 Geminin in cell differentiation 5.3 The structure of Geminin 5.3.1 The N-terminal domain 5.3.2 The coiled-coil domain 5.4 The structure of Cdt1 5.4.1 The N-terminal domain is highly regulated 5.4.2 The structurally conserved winged helix domains 5.4.3 The recruitment of Cdt1 on chromatin 5.5 The Cdt1-Geminin complex 5.5.1 The primary and secondary interfaces 5.5.2 The tertiary interface 5.5.3 Conformational change of the N-terminal domain? 5.6 Models for a Cdt1-Geminin molecular switch 5.7 Conclusions References
6. MCM structure and mechanics: what we have learned from archaeal MCM: Ian M. Slaymaker and Xiaojiang S. Chen 6.1 Introduction 6.2 Complex organization: Hexamers and double hexamers 6.3 Helicase activity 6.3.1 Steric exclusion 6.3.2 Ploughshare 6.3.3 LTag looping model (or strand exclusion) 6.3.4 Rotary pump 6.4 Domains and features of an MCM subunit 6.4.1 N domain 6.4.2 C domain 6.4.2.1 ATP binding pocket 6.4.2.2 Hairpins, helices and inserts 6.4.2.3 Winged helix domain 6.5 Inter- and intra-subunit communication 6.6 Higher-order MCM oligomers 6.7 Conclusions References
7. The Eukaryotic Mcm2-7 Replicative Helicase; Sriram Vijayraghavan and Anthony Schwacha 7.1 Introduction 7.2 The 'Mcm problem' and nonequivalent ATPase active sites 7.3 Discovery of Mcm2-7 helicase activity and the Mcm2/5 gate 7.3.1 Differences in circular ssDNA binding between Mcm2-7 and Mcm467 7.3.2 An in vitro condition that 'closes' Mcm2-7 stimulates its helicase activity 7.3.3 The Mcm2/5 'gate' model - the open conformation and DNA unwinding are mutually exclusive 7.4 The CMG complex 7.4.1 Discovery of the CMG complex 7.4.2 CMG structure - Cdc45 and GINS close the Mcm2/5 gate 7.4.3 Possible regu
Автор: Perumana R. Sudhakaran; Avadhesha Surolia Название: Biochemical Roles of Eukaryotic Cell Surface Macromolecules ISBN: 1493901605 ISBN-13(EAN): 9781493901609 Издательство: Springer Рейтинг: Цена: 22796.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cell surface molecules are critically important in regulating cell structure and function.
Автор: Lucy W. Barrett; Sue Fletcher; Steve D. Wilton Название: Untranslated Gene Regions and Other Non-coding Elements ISBN: 3034806787 ISBN-13(EAN): 9783034806787 Издательство: Springer Рейтинг: Цена: 8548.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes.
Автор: Joan H. Argyroudi-Akoyunoglou Название: Regulation of Choloroplast Biogenesis ISBN: 146136485X ISBN-13(EAN): 9781461364856 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ARW held in Crete, Greece, July 28-August 3, 1991
Автор: Tobias A. Oelschlaeger; J?rg H. Hacker Название: Bacterial Invasion into Eukaryotic Cells ISBN: 1441933301 ISBN-13(EAN): 9781441933300 Издательство: Springer Рейтинг: Цена: 46226.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Strategies of Bacterial Interaction with Eukaryotic Cells *Tobias A. Oelschlaeger and Jorg Hacker 1. BENEFICIAL BACTERIAL-HOST INTERACTIONS Already during birth and soon thereafter mammals are colonized by bacte- ria belonging to the resident microbial flora. Cutaneous and mucosal sur- faces and the gastrointestinal tract are the areas which become colonized. These indigenous or autochthonous bacteria have a variety of beneficial effects on their hosts. They play a protective role by bacterial antagonism in fighting infections (Hoszowski and Truszczynski, 1997; Hentges, 1979). Pro- duction of vitamin K is another essential contribution of the resident microbial flora to the health of the host (Hill, 1997). Even more important, studies with germ-free animals demonstrated the involvement of the microbial flora on the development of the immune system. Such animals have underdeveloped and relatively undifferentiated lymphoid tissues and low concentrations of serum immune globulins ( Cebra et at., 1998). They TOBIAS A. OELSCHLAEGER and JORG HACKER Institut filr Molekulare lnfektionsbiologie, Universitiit Wiirzburg, 97070 Wiirzburg, Germany. *Corresponding author; Phone: (0)931-312150; FAX: (0)931-312578; E-mail: t.oelschlaeger@mail.uni-wuerzburg.de xxix Tobias A. Oelschlaeger and Jorg Hacker also show defects in specific immune responsiveness and in nonspecific resistance induced by endotoxin, which may account for their lowered resis- tance. A more typical example of symbiotic interaction of bacteria with a host are bacteria like Ruminococcus in the gut of ruminants, essential for degradation of cellulose (Hobson, 1988). The closest benefical bacterial-host interactions are those of intracellular symbiotic bacteria and their host cells.
Автор: Yuriy A. Knirel; Miguel A. Valvano Название: Bacterial Lipopolysaccharides ISBN: 3709116937 ISBN-13(EAN): 9783709116937 Издательство: Springer Рейтинг: Цена: 18237.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides extensive coverage of bacterial lipopolysaccharide, also known as endotoxin. The work focuses on the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function.
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