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Inducing targeted protein degradation, Cromm, P


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Цена: 19800.00р.
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При оформлении заказа до: 2026-05-14
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Автор: Cromm, P   (П. Кромм)
Название:  Inducing targeted protein degradation
Перевод названия: П. Кромм: Вызывание целенаправленной деградации белков – от химической биологии до открытия лекарств
ISBN: 9783527350131
Издательство: Wiley
Классификация:
ISBN-10: 3527350136
Обложка/Формат: Hardback
Страницы: 384
Вес: 0.89 кг.
Дата издания: 28.12.2022
Язык: English
Размер: 250 x 179 x 24
Подзаголовок: From chemical biology to drug discovery and clinical applications
Ссылка на Издательство: Link
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Поставляется из: Англии
Описание: When the author`s two children (a boy and a girl) were young, they often crawled into bed with his wife and him in the morning, he would make up stories about two little mice, Ticklemouse and his friend Lively, who lived in the same house as the little boy or girl, depending on who was listening. Ticklemouse was the author`s right hand and Lively his left, and they loved to tickle the kids whenever the mice got excited during the story. He never knew where the stories would go as he made them up, but over time, several were repeated often enough that they became memorable. When his kids grew up and had kids of their own, the author wrote down four of the stories and discovered that they were just as popular with his grandkids. These stories of shared laughter and fun became The Adventures of Ticklemouse. The author hopes you and your children or grandchildren enjoy them as much as his did and still do.


Environmental Degradation in Asia

Автор: Ayad M. Fadhil Al-Quraishi, Yaseen T. Mustafa, Abd
Название: Environmental Degradation in Asia
ISBN: 3031121112 ISBN-13(EAN): 9783031121111
Издательство: Springer
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Цена: 18904.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This unique book focuses on environmental degradation in Asian countries including land degradation and soil erosion. The land degradation covers assessing environmental degradation using geospatial technology, land use land cover mapping, environmental and anthropogenic degradation, assessment of land degradation vulnerability, evaluation of the impact of earthquake and the environmental control of the sand dunes. It also addresses the soil degradation and environmental pollution and presents several case studies such as tectonic activity and erosion, assessment of aircraft sound, soil degradation assessment for the arid territories, soil pollution, waste engine oil contamination, soil degradation, soil erosion modelling, land use and land cover change and its effect on soil erosion changes. Additionally, the book discusses the impact of climate change, and human activities including urban environmental quality, air pollution and the impact of armed conflict on the environment. Moreover, topics such as vegetation degradation including forest changes, hydrological and agricultural drought are presented. The book includes authors and scientists from Egypt, Iraq, Iran, India, Mongolia, United Arab Emirates, Uzbekistan, Republic of Kazakhstan, USA, Turkey, South Africa, Italy, China, Malaysia, Poland and Russia. Graduate students, researchers, engineers, policy planners, policymakers and stockholders could benefit from the information and the knowledge in this book.

Bifurcations, Instabilities, Degradation in Geomechanics

Автор: George Exadaktylos; Ioannis G. Vardoulakis
Название: Bifurcations, Instabilities, Degradation in Geomechanics
ISBN: 3642080448 ISBN-13(EAN): 9783642080449
Издательство: Springer
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Цена: 26711.00 р.
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Описание: This is an up-to-date review of developments in the field of bifurcations and instabilities in geomechanics from some of the world`s leading experts. Leading international researchers and practitioners of the topics debate the developments and applications which have occurred over the last few decades.

Bifurcation and Degradation of Geomaterials in the New Millennium

Автор: Kam-Tim Chau; Jidong Zhao
Название: Bifurcation and Degradation of Geomaterials in the New Millennium
ISBN: 3319356402 ISBN-13(EAN): 9783319356402
Издательство: Springer
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Цена: 19376.00 р.
Наличие на складе: Нет в наличии.

Описание: Simulations of shear zones and cracks in engineering materials using extended Finite Element Method.- Discrete modelling of micro-structural phenomena in granular shear zones.- Modelling hydromechanical dilation geomaterial - cavitation and localization.- Fabric evolution and its effect on strain localization in sand.- Micro-mechanical observations of strain localization in granular soils during simple shear loading.- Grainsize evolution in open systems.- Numerical modeling of failure process in cohesive geomaterials.- Hydromechanical modelling of an initial boundary value problem: Studies of non-uniqueness with a second gradient continuum.- A FE model for hydro-mechanical coupling.- Numerical simulation and length scale calibration of micropolar hypoplastic model.- Micromechanical analysis of second order work in granular media.- Stability and bifurcation in reinforced boreholes.- Shear banding in torsion shear tests on cross-anisotropic deposits of fine Nevada sand.- Effects of flooding on crushable sand.- Numerical analysis of 1D seepage failure process of sandy materials by CWENO method.- Mechanisms of deformation in porous rocks at the grain scale.- The influence of fines content on the onset of instability and critical state line of silty sand.- A multiscale investigation of strain localization in cohesionless sand.- The effect of rotational degrees of freedom on the formation of deformation patterns in granular materials using digital image correlation.- Stick-slip motion and the associated frictional instability caused by vertical oscillations.- Investigation of direct shear interface test using micro-polar continuum approach.- Energy criterion of in-plane fracture propagation in geomaterials with rotating particles.- Dynamic instability in geomaterials associated with the presence of negative stiffness elements.- Numerical modeling of particle breaking process in granular materials: compaction and evolution of size distribution.- Onset of strain localization in unsaturated soils subjected to constant water content loading.- Double-scale assessment of micro-mechanics based constitutive models for granular materials undergoing mechanical degradation.- Hypoplastic constitutive modelling of grain damage under plane shearing.- Hierarchy of failure indicators in the failure analysis of geomaterials.- Static liquefaction of granular soils: the role of grain shape and size.- Static liquefaction and instability in granular media subjected to monotonic loading - A micromechanical investigation.- Capillary effect on critical length of force chains in partially saturated granular materials within the pendular regime.- Study on the initiation of strain localization in soils by 3D non-coaxial plasticity.- Micromechanics-based constitutive modeling and DEM simulation of localized failure in soil.- Thermally induced deformation and failure in shale under drained and undrained heating.- Instability of dissociation process of methane hydrate bearing soil.- Development of image analysis tools to evaluate in-situ evolution of the grain size distribution in sand subjected to breakage.- FEMНDEM multi-scale analysis of boundary value problems involving strain localization.- Evolution of packing structure in cyclic mobility and post-liquefaction of granular soils.- Experimental versus finite element approach to study scale dependent features in granular materials' stress and deformation fields.- Onset of strain localization in fiber reinforced composites subjected to plane stress loading.- Using shear strain localisation to model the fracturing around gallery in unsaturated Callovo-Oxfordian claystone.- Experimental study on the behavior of a plasticine material.- Thermodynamic analysis of instability in unsaturated soils.- Plastic deformations in granular materials with rotation of principal stress axes.- A framework to assess the controllability of wetting on unsaturated collapsible soils.- Model tensile cracking in soil

The Proteasome — Ubiquitin Protein Degradation Pathway

Автор: Peter Zwickl; Wolfgang Baumeister
Название: The Proteasome — Ubiquitin Protein Degradation Pathway
ISBN: 3642639712 ISBN-13(EAN): 9783642639715
Издательство: Springer
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Цена: 15957.00 р.
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Описание: The penultimate chapter rounds up the in- formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.

Protein Degradation in Health and Disease

Автор: Michele Reboud-Ravaux
Название: Protein Degradation in Health and Disease
ISBN: 3642627145 ISBN-13(EAN): 9783642627149
Издательство: Springer
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Цена: 12196.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Hochstrasser-Ubiquitin-Dependent Protein Degradation V619

Автор: Hochstrasser, Mark
Название: Hochstrasser-Ubiquitin-Dependent Protein Degradation V619
ISBN: 0128186674 ISBN-13(EAN): 9780128186671
Издательство: Elsevier Science
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Цена: 26275.00 р.
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Описание:

Ubiquitination and Protein Stability - Part B, Volume 619, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors. Topics of note include chapters on Assays of SUMO protease function in mammalian cells, In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation, Methods to study proteasome regulatory particle assembly, Native mass spectrometry approaches to study the proteasome, Single-molecule methods to study the ubiquitin-proteasome system, Assays for the function of ubiquitin in the mammalian endocytic pathway, and much more.

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in this series on enzymology
The Molecular Chaperones Interaction Networks in Protein Folding and Degradation

Автор: Walid A. Houry
Название: The Molecular Chaperones Interaction Networks in Protein Folding and Degradation
ISBN: 1493911295 ISBN-13(EAN): 9781493911295
Издательство: Springer
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Цена: 24392.00 р.
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Описание:

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion.

In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases.

This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​

Lysosomal Pathways of Protein Degradation

Автор: Dice, J Fred
Название: Lysosomal Pathways of Protein Degradation
ISBN: 1587060035 ISBN-13(EAN): 9781587060038
Издательство: Taylor&Francis
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Цена: 30624.00 р.
Наличие на складе: Нет в наличии.

Ubiquitin and Protein Degradation, Part B

Автор: Deshaies, Raymond J.
Название: Ubiquitin and Protein Degradation, Part B
ISBN: 0121828042 ISBN-13(EAN): 9780121828042
Издательство: Elsevier Science
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Цена: 26275.00 р.
Наличие на складе: Нет в наличии.

Environmental Degradation of Advanced and Traditional Engineering Materials

Автор: Hihara, Lloyd H.
Название: Environmental Degradation of Advanced and Traditional Engineering Materials
ISBN: 1439819262 ISBN-13(EAN): 9781439819265
Издательство: Taylor&Francis
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Цена: 33686.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Urban Growth and Land Degradation in Developing Cities

Автор: Maconachie, Roy
Название: Urban Growth and Land Degradation in Developing Cities
ISBN: 0754648281 ISBN-13(EAN): 9780754648284
Издательство: Taylor&Francis
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Цена: 24499.00 р.
Наличие на складе: Нет в наличии.

Thermal Degradation of Polymer Blends, Composites and Nanocomposites

Автор: P. M. Visakh; Yoshihiko Arao
Название: Thermal Degradation of Polymer Blends, Composites and Nanocomposites
ISBN: 3319034634 ISBN-13(EAN): 9783319034638
Издательство: Springer
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Цена: 20516.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book examines the thermal stability and the mechanism of degrading for every class of polymer substances as well as studies the effect on reinforcement to all classes. It also explores the thermal stability when nano particles are added.


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