Автор: Marta Filizola Название: G Protein-Coupled Receptors - Modeling and Simulation ISBN: 9400774222 ISBN-13(EAN): 9789400774223 Издательство: Springer Рейтинг: Цена: 19377.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses.
"G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation," a new volume in the "Methods in Cell Biology" series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation. Covers the increasingly appreciated cell biology field of G-protein-coupled receptorsIncludes both established and new technologiesContributed by experts in the fieldCovers topics such as signaling, trafficking, and regulation
Название: G Protein-Coupled Receptors: From Structure to Function ISBN: 1849731837 ISBN-13(EAN): 9781849731836 Издательство: Royal Society of Chemistry Рейтинг: Цена: 26926.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design.
Автор: Bruce G. Allen; Terence E. H?bert Название: Nuclear G-Protein Coupled Receptors ISBN: 1493917544 ISBN-13(EAN): 9781493917549 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Nuclear G-Protein Coupled Receptors: Methods and Protocols is a compilation of a number of conceptual and methodological aspects important for the validation and characterization of intacrine signaling systems.
Автор: Marta Filizola Название: G Protein-Coupled Receptors - Modeling and Simulation ISBN: 9402402586 ISBN-13(EAN): 9789402402582 Издательство: Springer Рейтинг: Цена: 17096.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses.
Описание: This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader`s particular GPCR of interest.
Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.
Автор: Tiina P. Iismaa; Trevor J. Biden; John Shine Название: G Protein-Coupled Receptors ISBN: 3662219328 ISBN-13(EAN): 9783662219324 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins).
From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.
Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scientific importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine β-synthase, and Oligomerization of Porphobilinogen Synthase.
Описание: "The classic account of the human tendency to follow orders, no matter who they hurt or what their consequences." - Washington Post Book WorldIn the 1960s, Yale University psychologist Stanley Milgram famously carried out a series of experiments that forever changed our perceptions of morality and free will.
Автор: Filizola Название: G Protein-Coupled Receptors in Drug Discovery ISBN: 1493949675 ISBN-13(EAN): 9781493949670 Издательство: Springer Рейтинг: Цена: 13415.00 р. Наличие на складе: Нет в наличии.
Описание: This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.
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