Twin And Family Studies Of Epigenetics,27, Li, Shuai

Автор: Johannes Backs, Timothy McKinsey
Название: Epigenetics in Cardiac Disease
ISBN: 3319414550 ISBN-13(EAN): 9783319414553
Издательство: Springer
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Цена: 12806.00 р. 18294.00 -30%
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Описание: This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

Автор: Tollefsbol Trygve
Название: Epigenetics in Human Disease
ISBN: 0128122153 ISBN-13(EAN): 9780128122150
Издательство: Elsevier Science
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Цена: 23075.00 р.
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Описание: Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders.

Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies.

Автор: Moskalev, Alexey
Название: Epigenetics of Aging and Longevity
ISBN: 0128110600 ISBN-13(EAN): 9780128110607
Издательство: Elsevier Science
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Цена: 19875.00 р.
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Описание:

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail.

Название: Epigenetics
ISBN: 1910190071 ISBN-13(EAN): 9781910190074
Издательство: Неизвестно
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Цена: 45980.00 р.
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Автор: Igor Kovalchuk; Franz J. Zemp
Название: Plant Epigenetics
ISBN: 1607616459 ISBN-13(EAN): 9781607616450
Издательство: Springer
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Цена: 17684.00 р.
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Описание: Epigenetics is one of the most popular and quickly evolving fields of modern science. In this book, expert researchers explore the most recent developments, examining in great detail the contribution of epigenetic regulation to cell function in plants.

Автор: Fazlul H. Sarkar
Название: Epigenetics and Cancer
ISBN: 9401780803 ISBN-13(EAN): 9789401780803
Издательство: Springer
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Цена: 20516.00 р.
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Описание: This book examines the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. It covers epigenetic regulation of mRNA as well as epigenetic regulation of miRNA in multiple cancers.

Автор: Mukesh Verma
Название: Cancer Epigenetics
ISBN: 1493918036 ISBN-13(EAN): 9781493918034
Издательство: Springer
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Цена: 24392.00 р.
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Автор: Reinhard Heil; Stefanie B. Seitz; Harald K?nig; J?
Название: Epigenetics
ISBN: 3658144599 ISBN-13(EAN): 9783658144593
Издательство: Springer
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Цена: 7317.00 р.
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Описание: Modern epigenetics unites scientists from life sciences, organic chemistry as well as computer and engineering sciences to find an answer to the question of how environmental influences can have a lasting effect on gene expression, maybe even into the next generations.

Автор: Walter Doerfler; Petra B?hm
Название: Epigenetics - A Different Way of Looking at Genetics
ISBN: 3319271849 ISBN-13(EAN): 9783319271842
Издательство: Springer
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Цена: 17074.00 р.
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Описание: This book presents epigenetics research as a new way of looking at genetics. Topics range from basic epigenetics mechanisms to development of cells and organisms and the biological basis of diseases. In addition the book focuses on immunology and the role of viruses in epigenetics.

Автор: Janos Minarovits; Hans Helmut Niller
Название: Patho-Epigenetics of Infectious Disease
ISBN: 3319247360 ISBN-13(EAN): 9783319247366
Издательство: Springer
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Цена: 18294.00 р.
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Описание: Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.

Автор: Trygve Tollefsbol
Название: Medical Epigenetics
ISBN: 0128032391 ISBN-13(EAN): 9780128032398
Издательство: Elsevier Science
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Цена: 22696.00 р.
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Описание: "

Medical Epigenetics" is an inclusive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic disease that affect these systems, and modes of treating epigenetic-based disorders and diseases. This book provides stand-alone coverage of all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. It is useful not only to physicians, nurses, medical students, and many others directly involved with healthcare, but also investigators in life sciences, biotech companies, graduate students, and all others who are interested in more applied aspects of epigenetics.

The expansion of the field of epigenetics has brought a wealth of information with respect to variations in phenotypes that are heritable. In addition, many advances have emerged that have shown epigenetic aberrations as central to a number of diseases and disorders that were previously thought to be manifested primarily through genetic factors. Along with the remarkable studies that have been made in our understanding of epigenetic-based diseases and disorders has come new information that allows treatments that target these many epigenetic aberrations. "Medical Epigenetics" brings all of this knowledge together to comprehensively review the state of medical epigenetics in one defining volume.

The basic design of "Medical Epigenetics" is to lead the reader from the fundamental mechanisms of epigenetics as they apply to humans through approaches for treating epigenetic-based diseases. This book begins with the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics. "Medical Epigenetics" closes with a chapter on future prospects in medical epigenetics. This book is by far the most complete book in the area of applied epigenetics.
Focuses on practical and applied aspects of medical epigeneticsIncludes peer-reviewed chapters with up-to-date coverage of emerging topics in medical epigenetics by leading expertsAppeals to those interested in fundamental epigenetics and inheritance, as well as those with more clinical interests including practicing physicians and other health care professionalsCovers the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics

Автор: Tollefsbol, Trygve
Название: The Epigenetics of Autoimmunity
ISBN: 0128099127 ISBN-13(EAN): 9780128099124
Издательство: Elsevier Science
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Цена: 23917.00 р.
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Описание: The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. . To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sj?gren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). . These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment.