Автор: Chi-Chao Chan Название: Animal Models of Ophthalmic Diseases ISBN: 3319792784 ISBN-13(EAN): 9783319792781 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience and the text is supported by numerous photos and diagrams. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents and medical students.
Автор: Malgorzata Kloc; Jacek Z. Kubiak Название: Marine Organisms as Model Systems in Biology and Medicine ISBN: 3030064425 ISBN-13(EAN): 9783030064426 Издательство: Springer Рейтинг: Цена: 34150.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book highlights the potential advantages of using marine invertebrates like tunicates, echinoderms, sponges and cephalopods as models in both biological and medical research. Bioactive compounds found in marine organisms possess antibacterial, antifungal, anti-diabetic and anti-inflammatory properties, and can affect the immune and nervous systems. Despite substantial research on the medicinal attributes of various marine invertebrates, they are still very much underrepresented in scientific literature: the majority of cell, developmental and evolutionary scientific journals only publish research conducted on a few well-known model systems like Drosophila melanogaster or Xenopus laevis.
Addressing that gap, this book introduces readers to new model organisms like starfish or nemertera. By showing their benefits with regard to regeneration, stem cell research and Evo-Devo, the authors provide a cross-sectional view encompassing various disciplines of biological research. As such, this book will not only appeal to scientists currently working on marine organisms, but will also inspire future generations to pursue research of their own.
Автор: Patricio O`Donnell Название: Animal Models of Schizophrenia and Related Disorders ISBN: 1493957880 ISBN-13(EAN): 9781493957880 Издательство: Springer Рейтинг: Цена: 17074.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Animal models of schizophrenia and other major psychiatric disorders have been sought for decades, and, as a result, we are now facing new vistas on pathophysiology that could lead to novel therapeutic approaches and even hint at possible preventive strategies. Animal Models of Schizophrenia and Related Disorders presents an overview of the information that can be obtained with several different models and a detailed account of how to generate such models in order to ensure that the manipulations used to model schizophrenia-relevant phenomena are used consistently across laboratories. This detailed volume features pharmacological models such as non-competing NMDA antagonists, emphasizing their use in vitro, neurodevelopmental models such as the neonatal ventral hippocampal lesion and the antimitotic MAM, models that reproduce environmental factors such as neonatal hypoxia, vitamin D deficits, and prenatal immune activation, as well as several different genetic model approaches. As a volume in the Neuromethods series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Practical and cutting-edge, Animal Models of Schizophrenia and Related Disorders highlights the successes in the use of animal models to gain insight on pathophysiological mechanisms of relevance to major psychiatric disorders in the hope of inspiring investigators to expand the research and test targets that could restore or ameliorate function.
Автор: Chao Ma; Jun-Ming Zhang Название: Animal Models of Pain ISBN: 1493957619 ISBN-13(EAN): 9781493957613 Издательство: Springer Рейтинг: Цена: 14635.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This authoritative book investigates a wide range of pain mechanisms. It seeks to lead scientists closer to the ultimate goal of improving the quality of life and relieving the unbearable burden of chronic pain for millions of people throughout the world.
Автор: Mary C. Olmstead Название: Animal Models of Drug Addiction ISBN: 1493957457 ISBN-13(EAN): 9781493957453 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Our understanding of addiction and how it is treated has advanced remarkably over the past decades, and much of the progress is related directly to animal research. This is true for both the behavioural aspects of drug use as well as the biological underpinnings of the disorder. In Animal Models of Drug Addiction, experts in the field provide an up-to-date review of complex behavioural paradigms that model different stages of this disorder and explain how each test is used to effectively replicate the progression of drug addiction. This detailed and practical book begins with the most common laboratory measures of addiction in animals, including intracranial self-stimulation (ICSS), drug self-administration, place conditioning, and sensitization. Later chapters describe how these paradigms are used to model the progression of drug addiction, providing insight into the clinical symptomatology of addiction from acquisition of drug use through compulsive drug taking to withdrawal and relapse. Written for the popular Neuromethods series, the contributions offer both methodological detail and a theoretical perspective, appealing to readers familiar with preclinical research on drug addiction as well as those who are newcomers to the field. Cutting-edge and authoritative, Animal Models of Drug Addiction will serve as a basis for future vital research that links the bench to the bedside in the crucial treatment of drug addiction.
Автор: Ricardo Mart?nez Murillo; Alfredo Mart?nez Название: Animal Models of Brain Tumors ISBN: 1493958941 ISBN-13(EAN): 9781493958948 Издательство: Springer Рейтинг: Цена: 17684.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book brings together developments in `in vivo` experimental tumor research of the last two decades that have advanced understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms.
Автор: Alan A. Boulton; Glen B. Baker; Roger F. Butterwor Название: Animal Models of Neurological Disease, I ISBN: 0896032086 ISBN-13(EAN): 9780896032088 Издательство: Springer Рейтинг: Цена: 22563.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The use of animal models continues to be the most reliable way of studying pathophysiologic mechanisms as well as treatments for neurological disorders. These two companion volumes highlight new information and techniques available in this rapidly growing area.
Автор: Jun Chen; Xiao-Ming Xu; Zao C. Xu; John H. Zhang Название: Animal Models of Acute Neurological Injuries II ISBN: 1493960520 ISBN-13(EAN): 9781493960521 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.
Автор: H?kan Aldskogius Название: Animal Models of Spinal Cord Repair ISBN: 1493961802 ISBN-13(EAN): 9781493961801 Издательство: Springer Рейтинг: Цена: 17684.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book in the Neuromethods series examines a range of experimental models for research on spinal cord injury, shows how they have contributed to our current state of knowledge, and describes their advantages in the further advancement of spinal cord repair.
Автор: Jun Chen; Xiao-Ming Xu; Zao C. Xu; John H. Zhang Название: Animal Models of Acute Neurological Injuries II ISBN: 1493962221 ISBN-13(EAN): 9781493962228 Издательство: Springer Рейтинг: Цена: 18904.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume collects information on acute neurological injuries from cells and molecules to behavior and imaging, a key to understanding disease mechanisms and to developing therapeutic strategies to ameliorate or even prevent damage to the nervous system.
Автор: Emma L. Lane; Stephen B. Dunnett Название: Animal Models of Movement Disorders ISBN: 149396240X ISBN-13(EAN): 9781493962402 Издательство: Springer Рейтинг: Цена: 17684.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents techniques for modeling and assessing motor function in experimental animals from lower orders through vertebrate species to mammals. Volume I offers methods for assessing movement disorder and an extensive section on dopamine systems.
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