This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Chandra Mouli Pandey, Bansi Dhar Malhotra Название: Biosensors: Fundamentals and Applications ISBN: 3110637804 ISBN-13(EAN): 9783110637809 Издательство: Walter de Gruyter Цена: 35161.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on the state-of-the-art of biosensor research and development for specialists and non-specialists. It introduces the fundamentals of the subject with relevant characteristics of transducer elements, as well as biochemical recognition molecules. This book is ideal for researchers of nanotechnology, materials science and biophysics.
Описание: This book is the first overview on Deep Learning (DL) for biomedical data analysis. The reader will require some familiarity with AI, ML and DL and will learn about techniques and approaches that deal with the most important and/or the newest topics encountered in the field of DL for biomedical data analysis.
Автор: Burns Malcolm, Foster Lucy, Walker Michael Название: DNA Techniques to Verify Food Authenticity: Applications in Food Fraud ISBN: 1788011783 ISBN-13(EAN): 9781788011785 Издательство: Royal Society of Chemistry Рейтинг: Цена: 23602.00 р. Наличие на складе: Поставка под заказ.
Описание: Providing the most comprehensive and timely collection of material from those working at the forefront of DNA techniques applied to food authenticity, this book will appeal to food testing laboratories worldwide and food policy professionals and regulatory organisations who will be using these techniques to back up legislation and regulation.
Описание: This book discusses topics related to bioinformatics, statistics, and machine learning, presenting the latest research in various areas of bioinformatics.
Автор: Amandeep S. Sidhu Название: Biomedical Data and Applications ISBN: 3642021921 ISBN-13(EAN): 9783642021923 Издательство: Springer Рейтинг: Цена: 26711.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Compared with data from general application domains, modern biological data has many unique characteristics. The goal of this book is to cover data and applications identifying new issues and directions for future research in biomedical domain.
Автор: Dey Название: Acoustic Sensors for Biomedical Applications ISBN: 3319922246 ISBN-13(EAN): 9783319922249 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, application-related studies for acoustic biomedical sensors are covered in depth. The book features an array of different biomedical signals, including acoustic biomedical signals as well as the thermal biomedical signals, magnetic biomedical signals, and optical biomedical signals to support healthcare.
The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.
This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.
The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.
Название: Gene-Mapping Techniques and Applications ISBN: 0367450607 ISBN-13(EAN): 9780367450601 Издательство: Taylor&Francis Рейтинг: Цена: 7195.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explains current strategies for mapping genomes of higher organisms and explores applications of gene mapping to agriculturally important species of plants and animals. It also explores the experimental techniques used for genetic and physical mapping of genes.
Описание: This book discusses topics related to bioinformatics, statistics, and machine learning, presenting the latest research in various areas of bioinformatics.
Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part A Volume 184, highlights many aspects of AIE materials that can help future investigators, researchers, students and stakeholders perform research with ease. Emitting light is a fascinating photophysical phenomenon, its different forms have brought the attention of various disciplines of natural sciences for centuries. In the modern era of scientific generation, short-lived fluorescence light and its long-lived counterpart phosphorescence light has been employed for several chemo-sensing, bio-sensing, and bioimaging applications. The aggregation induced emission (AIE) phenomenon has appeared as a wand of modern science to convert aggregation-caused quenching (ACQ) materials into AIE active materials for a wide range of biomedical applications including biosensing, bioimaging and localization of molecules for better understanding of molecular mechanisms. This volume covers a wide range of topics which are not currently available in a single volume, including ACQ & AIE concept development; intracellular pH, temperature and viscosity sensing; imaging of cell membrane, lipid droplet, lysosome, and mitochondria; biosensing and Imaging of bacteria; nucleus and nucleic acid imaging.
Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part B Volume 185, presents many aspects of AIE materials that can help future investigators, researchers, students and stakeholders perform research with ease. Fluorescence-based monitoring and diagnosis platforms furnish extensive insight into the molecular mechanisms of cellular processes and precisely guiding therapeutics. Traditional/conventional fluorophores are exhibiting high emission in the solution state and losses their emission on aggregation and solid forms. Loss of emission at aggregation and solid forms limits conventional fluorophores utilization in monitoring and diagnosis of biological processes. The AIE molecular system emerged as an alternative sophisticated platform to over the limitations of conventional organic/inorganic fluorophores. This volume offers various topics, including tissue & protein fibrils imaging by AIE active molecules; theranostic and photodynamic therapy applications of AIE materials for cancer cell treatment; AIE active polymers and MOF materials for biological applications.
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