B Cell Receptor Signaling, Kurosaki Tomohiro, Wienands Jurgen

Автор: Tomohiro Kurosaki; J?rgen Wienands
Название: B Cell Receptor Signaling
ISBN: 3319261312 ISBN-13(EAN): 9783319261317
Издательство: Springer
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Цена: 15957.00 р.
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Описание: Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, while also paving the way for eventually combating thesediseases.

Автор: Alexander Sigalov
Название: Multichain Immune Recognition Receptor Signaling
ISBN: 1441918876 ISBN-13(EAN): 9781441918871
Издательство: Springer
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Цена: 27931.00 р.
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Описание: This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

Автор: Gerard Pasterkamp
Название: Semaphorins: Receptor and Intracellular Signaling Mechanisms
ISBN: 1441924272 ISBN-13(EAN): 9781441924278
Издательство: Springer
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Цена: 27931.00 р.
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Описание: This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by semaphorins. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems.

Автор: Marie-Paule Lefranc
Название: The T Cell Receptor FactsBook,
ISBN: 0124413528 ISBN-13(EAN): 9780124413528
Издательство: Elsevier Science
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Цена: 13551.00 р.
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Описание: This is a reference for all functional and ORF T-cell receptor genes. Introductory chapters provide up-to-date information on T-cell receptor structural and biological properties, chain synthesis, gene chromosomal localization, and organization of the TRA, TRB, TRG and TRD loci. This is followed by entries on all 168 functional and ORF variable, diversity, joining and constant genes, and a complete overview of the potential repertoire of the human T-cell receptor alpha, beta, gamma and delta loc

Автор: Peter van den Elsen
Название: The Human T-Cell Receptor Repertoire and Transplantation
ISBN: 3662224968 ISBN-13(EAN): 9783662224960
Издательство: Springer
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Цена: 12196.00 р.
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Описание: these analyses it became clear that the MHC class I molecule com- prised a distinct groove on the external side of the molecule. * *- High resolu- tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules.

Автор: Gerald Litwack
Название: Receptor Purification
ISBN: 146126779X ISBN-13(EAN): 9781461267799
Издательство: Springer
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Цена: 18294.00 р.
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Автор: Vincent Laudet
Название: The Nuclear Receptor FactsBook,
ISBN: 0124377351 ISBN-13(EAN): 9780124377356
Издательство: Elsevier Science
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Цена: 12464.00 р.
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Описание: Devoted to nuclear receptors, this work presents an introduction and describes the mode of action of the receptors in general. It also contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure; Isolation; DNA binding properties; Ligands; Expression; Target genes; Knockouts; and more.

Автор: Xiaoting Zhang
Название: Estrogen Receptor and Breast Cancer
ISBN: 3319993496 ISBN-13(EAN): 9783319993492
Издательство: Springer
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Цена: 20733.00 р.
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Описание: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Автор: Alan A. Boulton; Glen B. Baker; Pavel D. Hrdina
Название: Receptor Binding
ISBN: 0896030784 ISBN-13(EAN): 9780896030787
Издательство: Springer
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Цена: 22563.00 р.
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