Clemmons David, Robinson Iain C. A. F. Igfs: Local Repair and Survival Factors Throughout Life Span 9783662505830

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Автор: Clemmons David, Robinson Iain C. A. F.
Название: Igfs: Local Repair and Survival Factors Throughout Life Span
ISBN: 9783662505830
Издательство: Springer
Классификация:

Физиология

Медицинская генетика

Эндокринология

ISBN-10: 3662505835
Обложка/Формат: Paperback
Страницы: 157
Вес: 0.25 кг.
Дата издания: 23.08.2016
Серия: Research and perspectives in endocrine interactions
Язык: English
Издание: Softcover reprint of
Иллюстрации: 1 tables, black and white; xiii, 157 p.; 1 tables, black and white; xiii, 157 p.
Размер: 23.39 x 15.60 x 0.94 cm
Читательская аудитория: General (us: trade)
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.
Дополнительное описание: GH & IGF1: Aspects of Global and Local Release and Actions.- Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation.- IGFBP2 Supports ex vivo Expansion of Hematopoietic Stem Cells.- The Role of Insulin-like Growth Factor-I in Centr

Igfs: Local Repair and Survival Factors Throughout Life Span, Clemmons David, Robinson Iain C. A. F.