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Glaucoma: a neurodegenerative disease of the retina and beyond part b, 


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Название:  Glaucoma: a neurodegenerative disease of the retina and beyond part b
ISBN: 9780323853415
Издательство: Elsevier Science
Классификация:



ISBN-10: 0323853412
Обложка/Формат: Hardcover
Страницы: 180
Вес: 1.00 кг.
Дата издания: 06.10.2020
Серия: Progress in brain research
Язык: English
Размер: 22.86 x 15.24 x 1.12 cm
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание: Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part B, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics covered in this new release include Glaucoma neurodegeneration and myopia, Links between obstructive sleep apnea and glaucoma neurodegeneration, Artificial intelligence and deep learning in glaucoma: Current state and future prospects, Brain networks reorganization and functional disability in glaucoma, Advanced vascular examinations of the retina and optic nerve head in glaucoma, and much more


Omic Studies of Neurodegenerative Disease - Part B,122

Автор: Michael J. Hurley
Название: Omic Studies of Neurodegenerative Disease - Part B,122
ISBN: 0128047623 ISBN-13(EAN): 9780128047620
Издательство: Elsevier Science
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Цена: 24423.00 р.
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Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields.

The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.

Metabolic And Bioenergetic Drivers Of Neurodegenerative Disease: Neurodegenerative Disease Research And Commonalities With Metabolic Diseases,154

Автор: Soderbom, Grazyna
Название: Metabolic And Bioenergetic Drivers Of Neurodegenerative Disease: Neurodegenerative Disease Research And Commonalities With Metabolic Diseases,154
ISBN: 0128200766 ISBN-13(EAN): 9780128200766
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer's and Parkinson's, as well as increasing evidence for the overlap between drivers of metabolic and neurodegenerative disease that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include Brain Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Diseases; the Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects, and the Metabolic Link to Alzheimer's Disease; the Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Diseases, the Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Diseases, and much more.

  • Summarizes the current status of and future research in Alzheimer's and Parkinson's diseases
  • Reviews the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases.
Metabolic And Bioenergetic Drivers Of Neurodegenerative Disease: Treating Neurodegenerative Diseases As Metabolic Diseases,155

Автор: Soderbom, Grazyna
Название: Metabolic And Bioenergetic Drivers Of Neurodegenerative Disease: Treating Neurodegenerative Diseases As Metabolic Diseases,155
ISBN: 0128231211 ISBN-13(EAN): 9780128231210
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer's and Parkinson's, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain - A Role in Type 2 Diabetes Mellitus and Alzheimer's disease; and much more.

Joint Imaging Applications in General Neurodegenerative Disease: Parkinsons, Frontotemporal, Vascular Dementia and Autism

Автор: Yongxia Zhou
Название: Joint Imaging Applications in General Neurodegenerative Disease: Parkinsons, Frontotemporal, Vascular Dementia and Autism
ISBN: 1536194352 ISBN-13(EAN): 9781536194357
Издательство: Nova Science
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Цена: 13462.00 р.
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Описание: Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinsons disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations. Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis. In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivity, intra- and inter-network correlation, systematic integration and efficiency analyses. Our objective, comprehensive and confirmative results indicated great potential in utilizing these quantifications for accurate disease classification and staging. With solid imaging evidence, thorough analysis and generalized applications, this book should capture the interests of readers in the broad fields of brain science, disease diagnosis and effective treatment.

Disease-Modifying Targets in Neurodegenerative Disorders

Автор: Baekelandt, Veerle
Название: Disease-Modifying Targets in Neurodegenerative Disorders
ISBN: 0128051205 ISBN-13(EAN): 9780128051207
Издательство: Elsevier Science
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Цена: 11706.00 р.
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Описание:

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.

This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.

  • Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
  • Summarizes how patients are treated today, providing a glance at future disease management
  • Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
  • Written and peer reviewed by outstanding scientists in their respective fields
Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases

Автор: Cummings
Название: Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases
ISBN: 3642063950 ISBN-13(EAN): 9783642063954
Издательство: Springer
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Цена: 27931.00 р.
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Описание: Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships.

Neuroglia in Neurodegenerative Diseases

Автор: Verkhratsky
Название: Neuroglia in Neurodegenerative Diseases
ISBN: 9811399123 ISBN-13(EAN): 9789811399121
Издательство: Springer
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Цена: 20733.00 р.
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Описание: This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Mitochondrial Inhibitors and Neurodegenerative Disorders

Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong
Название: Mitochondrial Inhibitors and Neurodegenerative Disorders
ISBN: 1468498215 ISBN-13(EAN): 9781468498219
Издательство: Springer
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Цена: 18294.00 р.
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Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.

Neurodegenerative Disorders as Systemic Diseases

Автор: Wada Keiji
Название: Neurodegenerative Disorders as Systemic Diseases
ISBN: 4431562982 ISBN-13(EAN): 9784431562986
Издательство: Springer
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Цена: 18294.00 р.
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Описание: This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

Автор: Claus W. Heizmann; Katharina Braun
Название: Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders
ISBN: 3662216914 ISBN-13(EAN): 9783662216910
Издательство: Springer
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Цена: 6097.00 р.
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Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice

Автор: Peplow Philip V., Martinez Bridget, Gennarelli Thomas A.
Название: Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice
ISBN: 1071617117 ISBN-13(EAN): 9781071617113
Издательство: Springer
Цена: 24392.00 р.
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Описание: This detailed book aims to provide an overview of novel bioinformatics resources for exploring diverse aspects of RNA biology. This edition focuses on methods dealing with non-coding RNA (miRNAs, circRNAs or lncRNAs), RNA modifications (m6A or RNA editing), single cell RNA-seq and statistical models to handle count data from RNA-seq experiments.

Genedis 2020: Genetics and Neurodegenerative Diseases

Автор: Vlamos Panayiotis
Название: Genedis 2020: Genetics and Neurodegenerative Diseases
ISBN: 3030787869 ISBN-13(EAN): 9783030787868
Издательство: Springer
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Цена: 36589.00 р.
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Описание: 1-Attitudes and smoking prevalence among undergraduate students in central Greece.

2-Care of patients with Alzheimer's disease

3-Regulation of antioxidant enzymes levels in rat brain

4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy.

5-Cerebral critical closing pressure at concomitant traumatic brain injury.

6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias

7-The Development of Antisense RNA Treatments using Engineered Protein Substrates

8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases

9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma

10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study

11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients

12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial

13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents

14-Stress system activation analysis in Greek female adolescents: a bioimpedance study

15-Kisspeptin and the genetic obesity interactome

16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis.

17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia

18-Ebola virus disease and current therapeutic strategies; A review

19-Hyperbaric Oxygen Therapy effect on "Kinesia Paradoxa" Brain Circuits

20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line

21-Phospholipid Fatty Acid Profile of Spirulina platensis

22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study

23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives

24-Force spectroscopy in mechanical protein domains unfolding

25-Investigating the genetic component of Parkinson's Disease.

26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition

27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases

28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students

29-Synthesis, in silico stuiesand biological evaluation of 1, 3,4 oxadiazino indole derivatives

30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies

31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy.

32-Microbes and the games they play

33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy

34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study

35-The effect of nutrients on Alzheimer's disease biomarkers: A metabolomic approach

36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease

37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases

38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1

39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome

40-Clinical and molecular study of common thrombophilia mutation prothrombin G2

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