Drug Discovery Targeting Drug-Resistant Bacteria, Kesharwani, Prashant
Автор: Vardanyan, Ruben (university Of Arizona, Tucson, A Название: Piperidine-based drug discovery ISBN: 0128051574 ISBN-13(EAN): 9780128051573 Издательство: Elsevier Science Рейтинг: Цена: 16666.00 р. Наличие на складе: Нет в наличии.
Описание:
Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives.
Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers.
The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics.
Explores this extremely important heterocycle to a high level of detail
Describes synthesis methods for 70 current drugs based on Piperidine scaffolds
Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine
Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs
Описание: <em>Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications</em> offers the latest the field has to offer to practitioners and academics alike, presented through theoretical frameworks, case studies, and future directions. This vital resource gathers an integrated pattern of high quality publications from around the world providing current, current edge and provocative scientific work in the three domains of pharmacoinformatics: decision making domains, knowledge utilisation and representation environment, and the technological and infrastructural context.
Автор: Speck-Planche, Alejandro Название: Multi-Scale Approaches in Drug Discovery ISBN: 0081011296 ISBN-13(EAN): 9780081011294 Издательство: Elsevier Science Рейтинг: Цена: 27791.00 р. Наличие на складе: Нет в наличии.
Описание:
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
After an introduction to multi-scale approaches outlining the need for and benefits of their use, the book goes on to explore a range of useful techniques and research areas, and their potential applications to this process. Profiling drug binding by thermodynamics, machine learning for predicting enzyme sub-classes, and multitasking models for computer-aided design and virtual compound screening are discussed, before the book goes on to review Alkaloid Menispermaceae leads, natural chemotherapeutic agents and methods for speeding up the design and virtual screening of therapeutic peptides. Flavonoids as multi-target compounds are then explored, before the book concludes with a review of Quasi-SMILES as a novel tool.
Collecting together reviews and original research contributions written by leading experts in the field, Multi-Scale Approaches to Drug Discovery highlights cutting-edge approaches and practical examples of their implementation for those involved in the drug discovery process at many different levels. Using the combined knowledge of medicinal, computational, pharmaceutical and bio- chemists, it aims to support growth in the multi-scale approach to promote greater success in the development of new drugs.
Автор: Brenneman Jehrod, Iyer Malliga R. Название: Anti-Fibrotic Drug Discovery ISBN: 178801510X ISBN-13(EAN): 9781788015103 Издательство: Royal Society of Chemistry Рейтинг: Цена: 26770.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Anti-fibrotic Drug Discovery is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.
Автор: Mark von Itzstein Название: Influenza Virus Sialidase - A Drug Discovery Target ISBN: 3034807791 ISBN-13(EAN): 9783034807791 Издательство: Springer Рейтинг: Цена: 22796.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented.
Автор: Burnett Ned Название: Current Progress in Drug Discovery and Development ISBN: 1632415429 ISBN-13(EAN): 9781632415424 Издательство: Неизвестно Рейтинг: Цена: 24140.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Drug discovery is a significant part of medicine, pharmacology and biotechnology, which is concerned with the discovery of new and improved drugs. The process involves high-throughput screening (HTS), which refers to the testing of chemicals for their ability to modify the target. Other methods of drug discovery include de novo drug design, fragment-based lead discovery and protein-directed dynamic combinatorial chemistry. Drug development is the process of launching new drugs into the market after the lead compounds are identified during the drug discovery process. This stage involves two processes namely, pre-clinical development and clinical phase. Drug development ensures that all parameters of safety, pharmacokinetics, metabolism and toxicity of the new drug are analyzed prior to clinical trials. This book presents researches and studies performed by experts across the globe in the fields of drug discovery and drug development. A number of latest researches have been included to keep the readers up-to-date with the global concepts in these areas of study.
Описание: Providing a comprehensive overview of the drug discovery and development pipeline, this book focuses on the integral role that computational biology methods play in this process. Covering technological advances and their relation to drug developmental processes, readers are exposed to new methods of discovery utilising the available technology.
Описание: This book reviews diversity-oriented synthesis (DOS), a leading and dynamic area in organic chemistry and drug discovery. It first covers key chemical methods for the generation of small molecules according to DOS principles as well as important classes of molecules generated through DOS approaches.
Автор: J. Mulzer; R. Bohlmann Название: The Role of Natural Products in Drug Discovery ISBN: 3662040441 ISBN-13(EAN): 9783662040447 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products.
Автор: Sandhya Kortagere Название: In Silico Models for Drug Discovery ISBN: 1627033416 ISBN-13(EAN): 9781627033411 Издательство: Springer Рейтинг: Цена: 13415.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book surveys in silico models, offering techniques to derive novel antimicrobial targets and methods for computing binding energies of drugs to their target proteins, plus protocols, materials lists, known pitfalls and more.
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