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Identification And Quantification Of Drugs, Metabolites, Drug Metabolizing Enzymes, And Transporters, Ma, Shuguang


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Автор: Ma, Shuguang
Название:  Identification And Quantification Of Drugs, Metabolites, Drug Metabolizing Enzymes, And Transporters
ISBN: 9780128200186
Издательство: Elsevier Science
Классификация:

ISBN-10: 0128200189
Обложка/Формат: Paperback
Страницы: 708
Вес: 1.16 кг.
Дата издания: 01.07.2020
Язык: English
Издание: 2 ed
Размер: 235 x 191 x 36
Подзаголовок: Concepts, methods and translational sciences
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decades numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.




Detection of Drugs and Their Metabolites in Oral Fluid

Автор: White, Robert
Название: Detection of Drugs and Their Metabolites in Oral Fluid
ISBN: 0128145951 ISBN-13(EAN): 9780128145951
Издательство: Elsevier Science
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Цена: 11445.00 р.
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Описание:

Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs.

This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment.

  • Compares different collection and testing systems to assist readers involved in clinical or forensic practice in selecting oral fluid as the matrix of choice
  • Provides a sound basis for the detection of drugs and their metabolites in oral fluid and the interpretation of both positive and negative
  • Places the need, or lack thereof, for specimen validity testing and confirmation testing in context with the purposes of oral fluid testing
  • Describes drugs and drug classes that can be tested, along with useful information on a patient/donor's drug status

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