Автор: Kursad Turksen Название: Autophagy in Health and Disease ISBN: 3030074579 ISBN-13(EAN): 9783030074579 Издательство: Springer Рейтинг: Цена: 14025.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases.
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
Автор: Kursad Turksen Название: Autophagy in Health and Disease ISBN: 3319981455 ISBN-13(EAN): 9783319981451 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases.
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy.
Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections.
Presents the most advanced information regarding the role of the autophagic system in life and death
Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment
Includes chapters authored by leaders in the field around the globe--the broadest, most expert coverage available
Автор: Jos? M. Fuentes Название: Toxicity and Autophagy in Neurodegenerative Disorders ISBN: 3319382128 ISBN-13(EAN): 9783319382128 Издательство: Springer Рейтинг: Цена: 15957.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
Автор: Maiuri Название: Autophagy Networks in Inflammation ISBN: 3319300776 ISBN-13(EAN): 9783319300771 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
Описание: This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
Many modern recommendations for improved health and wellness leave us feeling like we're expected to dance upon a tightrope just to avoid illness and chronic discomfort. We hear that eggs are good for us; then we hear that they're bad for us; next, we learn that we should only be eating the egg whites; then, only the yolks; and finally, that we should eat the entire egg, but only at certain times of day, or with specific nutrient pairings.
We're supposed to exercise more, but also rest more--meanwhile, we have to avoid going overboard with either activity. We should be eating less, but never skipping meals. We need more vitamin D, and should be practicing grounding and enjoying exercise outdoors... but we have to stay out of the sun.
If you're feeling frustrated, overwhelmed, dejected, exhausted, and just about ready to chuck every piece of fitness advice you've ever received out the window, then this is the book for you.
Autophagy is a hot topic within the health and wellness community, despite being a relatively new discovery; what sets it apart from other diets and lifestyle trends is that it isn't a fad, or a plan designed to sell cookbooks, pre-packaged meals, or lifestyle products--it's pure science. While some of the jargon used to describe it might be intimidating, the concepts of autophagy are less confusing than many dietary trends because they are consistent and reflective of the realities in our everyday experiences.
Furthermore, autophagy isn't only recommended as a weight loss tool, or a cure for illness; its potential benefits are vast and varied, from improved metabolic function, to reduced risk of dementia, to enhanced physical performance, and even reversed signs of aging. There may be no such thing as a panacea in this world, but autophagy sure does come close to meeting its definition.
Autophagy is a process of cellular cleansing. It's the natural process by which our cells recycle old, broken, or infected molecular matter. We all have autophagic responses at work in our bodies already, but the realities of modern life often work to slow or inhibit the process of autophagy as we grow older. If we can master the art of triggering enhanced autophagy, though, the potential rewards we can reap are truly staggering.
Within these pages, you will discover:
What autophagy is, and how it works on a cellular level
How to comprehend, and even describe, autophagic processes without any previous knowledge of cellular biology or metabolic function
The evolutionary purpose of autophagy
How to trigger autophagy through diet, physical activity, and manufactured stress
How to activate autophagy through fasting, and what to expect during a fast of almost any length
How autophagy works to promote weight loss, and then maintain reduced weight in the long-term
How to use autophagic processes to delay or prevent signs of aging
How autophagy can work to cure illness, chronic pain, and disease
How autophagy may hold the key to an eventual cure for cancer
And more...
Название: Autophagy in differentiation and tissue maintenance ISBN: 149398747X ISBN-13(EAN): 9781493987474 Издательство: Springer Рейтинг: Цена: 13415.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed book compiles state-of-the-art protocols from researchers actively working in the area of autophagy, a crucial cellular process that regulates numerous cellular functions. In order to accelerate advances in the field, the volume explores aspects of autophagy research where a better understanding of its role is vitally important, such as in the maintenance of stem cell subpopulations and the regulation of differentiation. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Autophagy in Differentiation and Tissue Maintenance: Methods and Protocols serves as an ideal guide for researchers seeking to expand our knowledge of this key cell biological action.
AMS: Discover how a one day starvation secret won the nobel prize. And how you can use it to lose weight and promote long-term health. Autophagy for Beginners: How to Combine Intermittent Fasting and Nobel Prize Winning Science for Rapid Weight Loss, Reducing Inflammation and Promoting Long-Term Health In 2016, Yoshinori Ohsumi won the Nobel Prize for his research on Autophagy. Not only does autophagy have lifechanging weight loss benefits... It may help treat cancer and neurodegenerative diseases like Alzheimer's. Why has this unique type of fasting only become established in the past couple of years? It's simple, the fat cats of our food industry establishment have billions riding on the outdated "3 square meals a day" lifestyle. And not only is this typical American lifestyle outdated, it's downright dangerous. However, there is another way. And inside this breakthrough book you'll discover: - How to lose weight faster while intermittent fasting - IBS pain? You can blame this common food - 5 superfoods you can find at your local supermarket - How inflamed is your body right now? Exactly what to ask your doctor to find out the truth. - How to increase autophagy without fasting for several days in a row - 7 best foods for nurturing gut health - Eat this "forgotten food" to reverse plaque build up in your arteries - How to properly do a water fast without feeling weak or getting hungry. - A handful of this food cuts risk of heart disease by 24% - 1 in 4 supplements failed quality tests at a leading independent lab. Discover which ones to throw out (acid test) - How to lose weight without working out every day - 3 beginner mistakes which actually prevent autophagy, and how to avoid them - Do you get autophagy during 16/8 fasting? The surprising truth ...and much, much more. Plus countless other health secrets... Including this "miracle beverage" which researchers at the University of Minnesota found lowered diabetes risk by 33%... drinking this also boosts the effectiveness of your fast... plus one drink to avoid which sneakily breaks your fast You'll also discover - How to avoid starvation mode while fasting - The raw truth about extended water fasting - Is too much autophagy bad? Get the answer from the world's leading expert - Why do dogs who eat 1 meal a day live 20% longer than dogs who eat 3 meals a day? - The 3 benefits of autophagy you probably didn't know about - Autophagy success stories - how one obese Mom lost 90lbs in less than 6 months and cured her diabetes All written in plain English. So you don't need a medical degree to understand and apply what's inside. This is not just a diet fad. This is a long-term gamechanger in the health and longevity space. Here's the deal. The traditional "calories in, calories out" weight loss method no longer works. And restrictive low-fat or vegan diets often leave you hungry and irritable. However, when you combine the keto diet with a 2016 Nobel Prize winning breakthrough known as autophagy - you get the keto diet on steroids So take control of your life and show your friends and family that there is a simple way to lose weight and be happy - scroll up and click "add to cart"
Автор: Zheng-Hong Qin Название: Autophagy: Biology and Diseases ISBN: 9811506019 ISBN-13(EAN): 9789811506017 Издательство: Springer Рейтинг: Цена: 26832.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.
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