Описание: This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease.
Описание: Written by active investigators who have made important contributions in their respective areas, this book offers an up-to-date and comprehensive review of the latest advances in DNA damage sensing, signaling and repair.
Автор: John Pollard; Nicola Curtin Название: Targeting the DNA Damage Response for Anti-Cancer Therapy ISBN: 3030093360 ISBN-13(EAN): 9783030093365 Издательство: Springer Рейтинг: Цена: 24392.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.
Описание: The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer.
Автор: Pollard Название: Targeting the DNA Damage Response for Anti-Cancer Therapy ISBN: 3319758349 ISBN-13(EAN): 9783319758343 Издательство: Springer Рейтинг: Цена: 24392.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR.
Автор: Kathleen Sakamoto; Eric Rubin Название: Modulation of Protein Stability in Cancer Therapy ISBN: 1441924019 ISBN-13(EAN): 9781441924018 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive monograph on the role of protein modulation in cancer therapeutics focuses on targeting molecules that regulate protein stability in a variety of tumors. Topics covered include ubiquitin ligases, deubiquitinating enzymes, and the proteasome.
Название: Protein tyrosine phosphatases in cancer ISBN: 1493981064 ISBN-13(EAN): 9781493981069 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
Автор: Andrew Emili; Jack Greenblatt; Shoshana Wodak Название: Systems Analysis of Chromatin-Related Protein Complexes in Cancer ISBN: 1493900897 ISBN-13(EAN): 9781493900893 Издательство: Springer Рейтинг: Цена: 17096.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book identifies RNA molecules associated with various chromatin-modifying machines. It explores the biological significance of chromatin machines in cancer (and the development and differentiation of stem cells).
Автор: Peter W.T. Pisters; Murray F. Brennan Название: Protein and Amino Acid Metabolism in Cancer Cachexia ISBN: 3662223481 ISBN-13(EAN): 9783662223482 Издательство: Springer Рейтинг: Цена: 13677.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer cachexia is a complex syndrome characterized by diminished nutrient intake and progressive tissue depletion manifest clinically as anorexia and weight loss.
Автор: Marcelo G. Kazanietz Название: Protein Kinase C in Cancer Signaling and Therapy ISBN: 1617796913 ISBN-13(EAN): 9781617796913 Издательство: Springer Рейтинг: Цена: 36468.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980`s with its identification as an effector of phorbol esters, natural products with tumor promoting activity.
Автор: Neel Название: Protein Tyrosine Phosphatases in Cancer ISBN: 1493936476 ISBN-13(EAN): 9781493936472 Издательство: Springer Рейтинг: Цена: 20516.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.
Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
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