Mathematical Modeling of Mitochondrial Swelling, Messoud Efendiev
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 30624.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Описание: The monograph applies sophisticated topological symmetry tools to biological applications of information theory, along with a Black-Scholes model invocation of the Data Rate Theorem which links information and control theories.
Автор: Peter Sutovsky Название: Cellular and Molecular Basis of Mitochondrial Inheritance ISBN: 3030045692 ISBN-13(EAN): 9783030045692 Издательство: Springer Рейтинг: Цена: 13415.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
Автор: J.J. Lemasters; C.R. Hackenbrock; R.G. Thurman; H. Название: Integration of Mitochondrial Function ISBN: 1489925538 ISBN-13(EAN): 9781489925534 Издательство: Springer Рейтинг: Цена: 26216.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Bernhard Kadenbach Название: Mitochondrial Oxidative Phosphorylation ISBN: 1493901567 ISBN-13(EAN): 9781493901562 Издательство: Springer Рейтинг: Цена: 25075.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation, showing how most of these occur in eukaryotic cells, but not in bacteria or archaea. Coverage includes mitochondrial genes and human disease.
Автор: Palmeira Название: Mitochondrial Bioenergetics ISBN: 1493978306 ISBN-13(EAN): 9781493978304 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Preface...Table of Contents...Contributing Authors... 1. Overview of Mitochondrial BioenergeticsVitor M.C. Madeira 2. Evaluation of Respiration with Clark Type Electrode in Isolated Mitochondria and Permeabilized Animal CellsAna M. Silva and Paulo J. Oliveira 3. High-Resolution FluoRespirometry and OXPHOS Protocols for Human Cells, Permeabilized Fibres from Small Biopsies of Muscle and Isolated MitochondriaCarolina Doerrier, Luiz F. Garcia-Souza, Gerhard Krumschnabel, Yvonne Wohlfarter, Andrбs T. Mйszбros, and Erich Gnaiger 4. High-Throughput Analysis of Mitochondrial Oxygen ConsumptionJames Hynes, Rachel L. Swiss, and Yvonne Will 5. Modulation of Cellular Respiration by Endogenously Produced Nitric Oxide in Rat Hippocampal SlicesAna Ledo, Rui M. Barbosa, and Joгo Laranjinha 6. Mitochondrial Membrane Potential (ΔΨ) Fluctuations Associated with the Metabolic States of MitochondriaJoгo S. Teodoro, Anabela P. Rolo, and Carlos M. Palmeira 7. Fluorescence Measurement of Mitochondrial Membrane Potential Changes in Cultured CellsDavid G. Nicholls 8. Comparison of Mitochondrial Incubation Media for Measurement of Respiration and Hydrogen Peroxide ProductionTimea Komlуdi, Ondrej Sobotka, Gerhard Krumschnabel, Nicole Bezuidenhout, Elisabeth Hiller, Carolina Doerrier, and Erich Gnaiger 9. Measurement of Proton Leak in Isolated MitochondriaCharles Affourtit, Hoi-Shan Wong, and Martin D. Brand 10. Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single or Two Photon Confocal MicroscopySean M. Davidson and Michael R. Duchen 11. Mitochondrial Permeability Transition Pore and Calcium HandlingRandi J. Parks, Elizabeth Murphy, and Julia C. Liu 12. Redox Equivalents and Mitochondrial BioenergeticsJames R. Roede, Young-Mi Go, and Dean P. Jones 13. Mitochondrial Bioenergetics by 13 C-NMR Isotopomer AnalysisRui A. Carvalho 14. Computational Modeling of Mitochondrial Function from a Systems Biology PerspectiveSonia Cortassa, Steven J. Sollott, and Miguel A. Aon 15. Monitoring the Mitochondrial Dynamics in Mammalian CellsLuca Simula and Silvia Campello 16. Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated MitochondriaHoi-Shan Wong, Pierre-Axel Monternier, Adam L. Orr, and Martin D. Brand 17. Plate-Based Measurement of Respiration by Isolated MitochondriaShona A. Mookerjee, Casey L. Quinlan, Helen Wong, Pratiksha Dighe, and Martin D. Brand 18. Detection of Iron Depletion- and Hypoxia-Induced Mitophagy in Mammalian CellsShun-ichi Yamashita and Tomotake Kanki 19. The Importance of Calcium Ions for Determining Mitochondrial Glycerol-3-Phosphate Dehydrogenase Activity When Measuring Uncoupling Protein 1 (UCP1) Function in Mitochondria Isolated from Brown Adipose TissueKieran J. Clarke and Richard K. Porter 20. Isolation and Analysis of Mitochondrial Small RNAs from Rat Liver Tissue and HepG2 CellsJulian Geiger and Louise T. Dalgaard 21. Imaging of Mitochondrial pH Using SNARF-1Venkat K. Ramshesh and John J. Lemasters 22. Relation between Mitochondrial Membrane Potential and ROS FormationJan Suski, Magdalena Lebiedzinska, Massimo Bonora, Paolo Pinton, Jerzy Duszynski, and Mariusz R. Wieckowski
Автор: Lee-Jun C. Wong Название: Mitochondrial Disorders ISBN: 1493959506 ISBN-13(EAN): 9781493959501 Издательство: Springer Рейтинг: Цена: 17684.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The variability of clinical symptoms in mitochondrial diseases calls for a systematic presentation of the full range of protocols used in their assessment. This volume provides cutting-edge methods of analysis as well as expert guidance on how to apply them.
Автор: Volkmar Weissig; Marvin Edeas Название: Mitochondrial Medicine ISBN: 1493922874 ISBN-13(EAN): 9781493922871 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction.
Автор: Gaetano Santulli Название: Mitochondrial Dynamics in Cardiovascular Medicine ISBN: 3319856308 ISBN-13(EAN): 9783319856308 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.
Автор: Gaetano Santulli Название: Mitochondrial Dynamics in Cardiovascular Medicine ISBN: 3319553291 ISBN-13(EAN): 9783319553290 Издательство: Springer Рейтинг: Цена: 28051.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.
Автор: Paulo J. Oliveira Название: Mitochondrial Biology and Experimental Therapeutics ISBN: 3030103587 ISBN-13(EAN): 9783030103583 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
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