Exosomes, Stem Cells and MicroRNA, Karl L. Mettinger; Pranela Rameshwar; Vinod Kumar
Автор: Mettinger Название: Exosomes, Stem Cells and MicroRNA ISBN: 3319744690 ISBN-13(EAN): 9783319744698 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.
Автор: Yaoliang Tang Название: Mesenchymal Stem Cell Derived Exosomes ISBN: 012800164X ISBN-13(EAN): 9780128001646 Издательство: Elsevier Science Рейтинг: Цена: 12462.00 р. Наличие на складе: Нет в наличии.
Описание: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.
Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.
Covers emerging pharmaceutical and diagnostic applications, including exosomes being tested as carriers of anticancer drugs, ongoing clinical trials, and exosomes as imaging agents for cancer diagnosis and treatment
Brings together a team of highly regarded international authors who provide a full-rounded analysis
Presents comprehensive coverage of the unique biophysical properties of exosomes
Explores current and future possibilities
Автор: Andrew Francis Hill Название: Exosomes and Microvesicles ISBN: 1493967266 ISBN-13(EAN): 9781493967261 Издательство: Springer Рейтинг: Цена: 14635.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume covers methods for the analysis of extracellular vesicles (EV) that can be applied to isolated EVs from a wide variety of sources. This includes the use of electron microscopy, tunable resistance pulse sensing, and nanoparticle tracking analysis. The chapters in this book discuss EV cargoes containing proteins and genomic materials using a number of different approaches, and isolating EVs from platelets and neuronal cells and tissues. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and comprehensive, Exosomes and Microvesicles: Methods and Protocols is a valuable resource containing methodologies for anyone interested in researching EVs.
Автор: Zhang Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 1607617684 ISBN-13(EAN): 9781607617686 Издательство: Springer Рейтинг: Цена: 19514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.
Автор: Baohong Zhang; Edmund J. Stellwag Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 149395749X ISBN-13(EAN): 9781493957491 Издательство: Springer Рейтинг: Цена: 17074.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent stem cell research has revealed that miRNA and RNAi-mediated gene regulation is one of the vital determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluripotent cell fate determination. In RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications, expert authors from laboratories across the globe contribute an accessible compendium of up-to-date, proven methods focused on the study of the titular topic. Divided into three sections, the book first gives a brief introduction to RNAi and miRNAs in stem cells, with a focus on the current status of research and future perspectives, then it continues with detailed methods and protocols for RNAi screening, transfection, and the knockdown of specific genes and pathways in several animal species, including humans and mice, concluding with a section on recently developed methods for identification of miRNAs, including a general protocol for preparation and analysis of miRNA libraries for deep sequencing, knock down of a specific gene using miRNA-based shRNA, and miRNA expression analysis using qRT-PCR. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications serves as a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and the exciting areas of medicine, including regenerative medicine, aging, cancer, and neurological disorders, that can be advanced through this expanding area of research.
Автор: Zhiguo Wang; Baofeng Yang Название: MicroRNA Expression Detection Methods ISBN: 3642425186 ISBN-13(EAN): 9783642425189 Издательство: Springer Рейтинг: Цена: 25075.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides comprehensive descriptions of the innovative strategies and methodologies for detecting miRNA expression as well as their application in miRNA research and their potential as tools for clinical diagnosis and prognosis.
Автор: Shao-Yao Ying Название: MicroRNA Protocols ISBN: 1617376566 ISBN-13(EAN): 9781617376566 Издательство: Springer Рейтинг: Цена: 22563.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: MicroRNA Protocols provides diverse, novel, and useful descriptions of miRNAs in several species, including plants, worms, flies, fish, chicks, mice, and humans. These include some useful adaptations and applications that could be relevant to the wider research community who are already familiar with the identification of miRNAs.
Автор: Fazlul H. Sarkar Название: MicroRNA Targeted Cancer Therapy ISBN: 3319376063 ISBN-13(EAN): 9783319376066 Издательство: Springer Рейтинг: Цена: 17096.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass.
Автор: Zengrong Liu; Jianwei Shen; Shuiming Cai; Fang Yan Название: MicroRNA Regulatory Network: Structure and Function ISBN: 9402415750 ISBN-13(EAN): 9789402415759 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses topics related to the topological structure and biological function of gene networks regulated by microRNAs. It focuses on analyzing the relation between topological structure and biological function, applying these theoretical results to gene networks involving microRNA, illustrating their biological mechanisms, and identifying the roles of microRNA in controlling various phenomena emerging from the networks. In addition, the book explains how to control the complex biological phenomena using mathematical tools and offers a new perspective on studying microRNA. It is a useful resource for graduate students and researchers who are working on or interested in microRNAs and gene network.
Автор: Jingshan Huang; Glen M. Borchert; Dejing Dou; Jun Название: Bioinformatics in MicroRNA Research ISBN: 1493970445 ISBN-13(EAN): 9781493970445 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. MicroRNAs, Long Non-Coding RNAs, and Their Functions in Human Disease
Min Xue, Ying Zhuo, and Bin Shan
2. MicroRNA Expression: Protein Participants in MicroRNA Regulation
4. MicroRNAs: Biomarkers, Diagnostics, and Therapeutics
Weili Huang
5. Relational Databases and Biomedical Big Data
N.H. Nisansa D. de Silva
6. Semantic Technologies and Bio-Ontologies
Fernando Gutierrez
7. Genome-Wide Analysis of MicroRNA-Regulated Transcripts
David Chevalier and Glen M. Borchert
8. Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources
Justin T. Roberts and Glen M. Borchert
9. Exploring MicroRNA:: Target Regulatory Interactions by Computing Technologies
Yue Hu, Wenjun Lan, and Daniel Miller
10. The Limitations of Existing Approaches in Improving MicroRNA Target Prediction Accuracy
Rasiah Loganantharaj and Thomas A. Randall
11. Genomic Regulation of MicroRNA Expression in Disease Development
Feng Liu
12. Next Generation Sequencing for MicroRNA Expression Profile
Yue Hu, Wenjun Lan, and Daniel Miller
13. Handling High-Dimension (High-Feature) MicroRNA Data
Yue Hu, Wenjun Lan, and Daniel Miller
14. Effective Removal of Noisy Data Via Batch Effect Processing
Ryan G. Benton
15. Logical Reasoning (Inferencing) on MicroRNA Data
Jingsong Wang
16. Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions
Sumi Singh, Ryan G. Benton, Anurag Singh, and Anshuman Singh
17. Involvement of MicroRNAs in Diabetes and Its Complications
Bin Wu and Daniel Miller
18. MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role
Lihua Zhang, Daniel Miller, Qiuping Yang, and Bin Wu
19. Expression of MicroRNAs in Thyroid Carcinoma
Gaohong Zhu, Lijun Xie, and Daniel Miller
Название: Regulatory microRNA ISBN: 3038977683 ISBN-13(EAN): 9783038977681 Издательство: Неизвестно Рейтинг: Цена: 11918.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.
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