Описание: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
Автор: Jeffrey K. Aronson Название: Meyler`s Side Effects of Antimicrobial Drugs, ISBN: 0444532722 ISBN-13(EAN): 9780444532725 Издательство: Elsevier Science Рейтинг: Цена: 8420.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Suitable for internal medicine physicians and general practitioners who prescribe antibiotic drugs, like penicillin and tetracycline that cure bacterial infections, and antiviral drugs used to treat patients with HIV and herpes viruses.
Автор: Eswari, Jujjvarapu Satya (national Institute Of Technology, Raipur, India) Dhagat, Swasti (national Institute Of Technology, Raipur, India) Yadav, Man Название: Computer-aided design of antimicrobial lipopeptides as prospective drug candidates ISBN: 1138497509 ISBN-13(EAN): 9781138497504 Издательство: Taylor&Francis Рейтинг: Цена: 28327.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The authors focus on the properties of various lipopeptides which are produced as metabolites by bacteria and have shown to have antimicrobial properties. They provide a step-by-step method in identifying drug molecules for target compounds and testing various properties for drug efficacy. Both experienced researchers and beginners will benefit.
Автор: Nightingale Charles H Название: Antimicrobial Pharmacodynamics ISBN: 0824729250 ISBN-13(EAN): 9780824729257 Издательство: Taylor&Francis Рейтинг: Цена: 35983.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antimicrobial Pharmacodynamics in Theory and Clinical Practice
Автор: Wilson John W Название: Mayo Clinic Antimicrobial Therapy ISBN: 0190696923 ISBN-13(EAN): 9780190696924 Издательство: Oxford Academ Рейтинг: Цена: 6454.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The medical management of infectious diseases and antimicrobial therapy can be a daunting task for health care professionals. Infectious diseases experts at Mayo Clinic provide a coordinated, unified approach to infectious disease treatment for the general patient population as well as the complex patients seen at this internationally renowned destination medical center. Over twenty contributors represent the spectrum of infectious disease experience within the Mayo Clinic framework of patient-centered care. Highlights of Mayo Clinic Antimicrobial Therapy: Quick Guide, Third Edition include simplified and thorough drug dosing recommendations for renal function and renal replacement therapies, drugs of choice for specific organisms (including bacteria, fungi, and viruses), and updated and simplified antimicrobial and management recommendations for specific infectious syndromes. New features of the third edition include dosing recommendations for extended infusions and obese and neonatal patient populations and treatment options targeted for hepatitis B and C infections, prosthetic joint infections, post-transplant infections, and infections resulting from bioterrorism. This compact, user-friendly resource brings the specialized knowledge of Mayo Clinic to your fingertips.
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