Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.
Автор: Gary D. Lopaschuk; Naranjan S. Dhalla Название: Cardiac Energy Metabolism in Health and Disease ISBN: 1493948792 ISBN-13(EAN): 9781493948796 Издательство: Springer Рейтинг: Цена: 15957.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease.
Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
Автор: Karl-Hermann Neumann; Wolfgang Barz; Ernst Reinhar Название: Primary and Secondary Metabolism of Plant Cell Cultures ISBN: 364270719X ISBN-13(EAN): 9783642707193 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It must have been some feeling of frustration invoked by the genus loci of big conferences which brought Don Dougall, Mike Fowler, and me over a cup of coffee to think of organizing a small meeting on cell culture metabol- ism.
Автор: Alfred Locker; Alfred Locker; F. Kr?ger Название: Quantitative Biology of Metabolism ISBN: 3540043012 ISBN-13(EAN): 9783540043010 Издательство: Springer Рейтинг: Цена: 10610.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The last step implies the introduction of theoretical concepts, but we are not justified in speaking of theoretical science unless true theoretical con- siderations-models or hypotheses-precede experiment, and this is then followed by an attempt to link results with theory so as to verify the theory.
Описание: Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism.
From the Lab to Clinical Settings--Advances in Quantitative, Noninvasive Optical Diagnostics
Noninvasive fluorescence imaging techniques, novel fluorescent labels, and natural biomarkers are revolutionizing our knowledge of cellular processes, signaling and metabolic pathways, the underlying mechanisms for health problems, and the identification of new therapeutic targets for drug discoveries. Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications delves into the current state of knowledge on intrinsic fluorescent biomarkers and highlights recent developments in using these biomarkers for the metabolic mapping and clinical diagnosis of healthy and diseased cells and tissues.
Autofluorescent Biomarkers for Biomedical Diagnostics
The book's first section introduces the fundamentals of cellular energy metabolism as well as natural biomarkers within the context of their biological functions. The second section outlines the theoretical and technical background of quantitative, noninvasive, autofluorescence microscopy and spectroscopy methods, including experimental design, calibration, pitfalls, and remedies of data acquisition and analysis. The last two sections highlight advances in biomedical and biochemical applications, such as monitoring stem cell differentiation in engineered tissues and diagnosing cancer and ophthalmic diseases quantitatively and noninvasively.
Tailored to Interdisciplinary Researchers
Covering cell biology, imaging techniques, and clinical diagnostics, this book provides readers with a complete guide to studying cellular/tissue metabolism under healthy, diseased, and environment-induced stress conditions using natural biomarkers. The book is designed for graduate and advanced undergraduate students, biophysics instructors, medical researchers, and those in pharmaceutical R&D.
Автор: G. Rickey Welch; James S. Clegg Название: The Organization of Cell Metabolism ISBN: 1468453130 ISBN-13(EAN): 9781468453133 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The NATO Advanced Research Workshop on nThe Organization of Cell n Metabolism was held 31 August - 4 September, 1985, at the Hotel Hansthol m in Hansthollllt Denmark. From areas of cell biology, bio- chemistry, enzymology, and biophysical chemistry, the Workshop brought together workers whose research focuses on the character of the metabolic infrastructure of the living cell. The organizing committee was composed of the following members: James S. Clegg Douglas B. Kell Paul A. Srere G. Rickey Welch (Chairman) There has now arisen an edifice of proof that cell metabolism is highly ordered in space and time. The refinement of cytological extraction methodology and the development of more gentle isolation techniques have led to the demonstration of structural organization for most of the primary metabolic pathways. Moreover, the study of isolated enzyme complexes and membranous arrays has revealed unique functional properties of the organized state. Interest in metabolic organization has heightened very recently, due to the emergence of exciting new cytochemical and electron-microscopic advances in the elucidation of the cytOOIatrix and associated cell water. The hyaloplasmic space of eukaryotic cells has now been shown to be laced with a dense network of various filamentous structures - one role of which appears to be that of a structural support for the microcompartmentation of metabolic processe The supramolecular organization of certain processes may exceed the physical confines of intracellular particulates, involving large-scale entrainment of the cytoplasm in space and time.
Автор: M. Nasir Khan; Mohammad Mobin; Firoz Mohammad; Fra Название: Nitric Oxide in Plants: Metabolism and Role in Stress Physiology ISBN: 3319067095 ISBN-13(EAN): 9783319067094 Издательство: Springer Рейтинг: Цена: 24392.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the key features of nitric oxide (NO) in plants. Comprising nine chapters, Part I highlights its metabolism and identification in plants. Part II, which consists of eight chapters, focuses on the chemical, physical and biochemical properties of the NO molecule and its derivatives; on its functional role and mode of action; and on its signaling and interaction with phytohormones, mineral nutrients, biomolecules, ions and ion channels in plants under abiotic stresses. Combining the expertise of leading researchers in the field, the book provides a concise overview of plant NO biology and offers a valuable reference work.
Автор: J. Bell; P. Dunnill; K. Esser; E. Flaschel; M. Hoa Название: Downstream Processing ISBN: 3662153289 ISBN-13(EAN): 9783662153284 Издательство: Springer Рейтинг: Цена: 14818.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Gary Fiskum Название: Cell Calcium Metabolism ISBN: 1468456008 ISBN-13(EAN): 9781468456004 Издательство: Springer Рейтинг: Цена: 6097.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Particular attention is given to the molecular basis for plasma membrane transport activities, 2 2 including the ATP-driven Ca + pump, the Na + -Ca + exchange system, and voltage sensitive 2 Ca + channels.
Автор: Martina Heer; Jens Titze; Scott M. Smith; Natalie Название: Nutrition Physiology and Metabolism in Spaceflight and Analog Studies ISBN: 3319185209 ISBN-13(EAN): 9783319185200 Издательство: Springer Рейтинг: Цена: 6707.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an overview of microgravity-induced changes in human metabolism, muscle, bone and the cardio-vascular system, and discusses in detail the nutrient uptake required during spaceflight to counteract these adaptive mechanisms and ensure an improved physical constitution upon returning to Earth. It addresses the needs of professors, researchers and students working in the field of human physiology and nutrition.
Автор: Livio Luzi Название: Cellular Physiology and Metabolism of Physical Exercise ISBN: 8847058120 ISBN-13(EAN): 9788847058125 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book covers areas of cellular physiology and metabolism that are of interest to scientists involved in research in diabetes and metabolic diseases. Some chapters of the book are specifically research-oriented, as all the authors are actively practicing either bench or clinical research in the area. Nonetheless, since the work is fully comprehensive of the discipline, it is also suitable for university classes of graduate and undergraduate students. In particular, the book discusses classical aspects of cellular physiology and the metabolism of physical exercise, as well as novel topics like exercise in transplantation and exercise in beta-cell failure, which mark the frontiers of research in sport-related sciences and research. Exercise physiologists, biologists and physicians are the specific professional and academic targets of this work. The team of authors together with the editor are world-renowned experts in the field of physiology and metabolism applied to sport sciences.
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