Описание: Discusses various aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. This book explains the principles and applications of techniques used in the field of molecular genetics. It also translates molecular genetics into cancer diagnosis.
Описание: Discusses various aspects of immunohistochemistry and in situ hybridization technologies and the role they play in reaching a cancer diagnosis. This work provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, and the benefits and limitations of each method.
Название: FISH (Fluorescence in Situ Hybridization) ISBN: 0199638845 ISBN-13(EAN): 9780199638840 Издательство: Oxford Academ Рейтинг: Цена: 21226.00 р. Наличие на складе: Поставка под заказ.
Описание: FISH (Fluorescence In Situ Hybridization) is a versatile technique that is constantly being applied to branches of research. With over 100 protocols, this book will be of significant interest to students and technicians in both clinical service and basic science laboratories who employ genetic or genomic technologies.
Автор: Joanna M. Bridger; Keith Morris Название: Fluorescence in situ Hybridization (FISH) ISBN: 1493957244 ISBN-13(EAN): 9781493957248 Издательство: Springer Рейтинг: Цена: 18294.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Fluorescence in situ Hybridization (FISH) belongs to that special category of well-established molecular biology techniques that, since their inception a few decades ago, have succeeded in keeping a prominent position within the constantly expanding list of laboratory pro- dures for biomedical research and clinical diagnostics. The design simplicity and cost-effectiveness of the early FISH protocols, combined with the signifcant acceleration of discoveries in related technical areas such as fuor- cence microscopy, digital imaging, and nucleic acid technology have prompted the div- sifcation of the original technique into an outstanding number of imaginative and useful applications, and thus have not only held back its outmoding but have also promoted its expansion into different areas of basic and applied research in the post-genomic era. The 34 chapters included in this book aim at portraying the vibrant complexity and diversity of the current FISH protocol landscape, providing cutting-edge examples of va- ous applications for genetic and developmental research, cancer research, reproductive medicine, diagnostic and prognostic purposes, microbial ecology, and evolutionary st- ies. The book is divided in four parts: (I) Core Techniques, (II) Technical Advancements and Novel Adaptations, (III) Translational FISH: Applications for Human Genetics and Medicine, and (IV) Protocols for Model Organisms.
Автор: Ashley T. Haase; Michael B.A. Oldstone Название: In Situ Hybridization ISBN: 3642744273 ISBN-13(EAN): 9783642744273 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading researchers present contemporary treatment of in situ hybridization applied to current issues in animal virus pathogenesis. The genetic programs played out in these cells and the newer methods of hybridization at the electron microscopic level provide valuable insight into the complexities of virus-host interaction.
Автор: Boye Schnack Nielsen Название: In Situ Hybridization Protocols ISBN: 1493955268 ISBN-13(EAN): 9781493955268 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Situ Hybridization Protocols, Fourth Edition contains 21 protocols that utilize the in situ hybridization technology to document or take advantage of the visualization of specific RNA molecules.
Автор: G.R. Coulton; J. de Belleroche Название: In Situ Hybridization: Medical Applications ISBN: 940105326X ISBN-13(EAN): 9789401053266 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In situ hybridization has developed as a means of localizing specific DNA and RNA sequences within tissues. Complementary DNA, RNA or oligonucleotide probes, suitably labelled, are hybridized to specific DNA or RNA targets within tissues.
Описание: This Methods in Molecular Biology book details approaches for the detection of DNA and RNA including recovery of trace amounts of DNA for amplification and analysis, new qPCR chemistries, step-by-step, reproducible protocols, materials lists, tips and more.
Автор: Peter B. Gahan Название: Circulating Nucleic Acids in Plasma and Serum ISBN: 9400790414 ISBN-13(EAN): 9789400790414 Издательство: Springer Рейтинг: Цена: 26711.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: DNA and RNA fractions have been isolated from the whole blood, serum, plasma, the surface of blood cells, urine, saliva and spinal fluid from both healthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules and their use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis and prognosis.
Автор: Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar Название: Chemical Biology of Nucleic Acids ISBN: 3642544517 ISBN-13(EAN): 9783642544514 Издательство: Springer Рейтинг: Цена: 26832.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
Автор: Jurga Название: Modified Nucleic Acids in Biology and Medicine ISBN: 3319341731 ISBN-13(EAN): 9783319341736 Издательство: Springer Рейтинг: Цена: 20733.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Автор: Volker A. Erdmann; Jan Barciszewski Название: From Nucleic Acids Sequences to Molecular Medicine ISBN: 364243083X ISBN-13(EAN): 9783642430831 Издательство: Springer Рейтинг: Цена: 25075.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by leading experts in the field , this book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medicine. Includes numerous illustrations.
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