The Enzymology of the Cell Surface Tension at the Cell Surface, Aser Rothstein; Edmund N. Harvey

Автор: Greg Lever
Название: Large-Scale Quantum-Mechanical Enzymology
ISBN: 3319193503 ISBN-13(EAN): 9783319193502
Издательство: Springer
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Цена: 13415.00 р.
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Описание: This work establishes linear-scaling density-functional theory (DFT) as a powerful tool for understanding enzyme catalysis, one that can complement quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics simulations. The thesis reviews benchmark studies demonstrating techniques capable of simulating entire enzymes at the ab initio quantum-mechanical level of accuracy. DFT has transformed the physical sciences by allowing researchers to perform parameter-free quantum-mechanical calculations to predict a broad range of physical and chemical properties of materials. In principle, similar methods could be applied to biological problems. However, even the simplest biological systems contain many thousands of atoms and are characterized by extremely complex configuration spaces associated with a vast number of degrees of freedom. The development of linear-scaling density-functional codes makes biological molecules accessible to quantum-mechanical calculation, but has yet to resolve the complexity of the phase space. Furthermore, these calculations on systems containing up to 2,000 atoms can capture contributions to the energy that are not accounted for in QM/MM methods (for which the Nobel prize in Chemistry was awarded in 2013) and the results presented here reveal profound shortcomings in said methods.

Автор: Greg Lever
Название: Large-Scale Quantum-Mechanical Enzymology
ISBN: 3319369474 ISBN-13(EAN): 9783319369471
Издательство: Springer
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Цена: 11397.00 р.
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Описание: This work establishes linear-scaling density-functional theory (DFT) as a powerful tool for understanding enzyme catalysis, one that can complement quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics simulations.

Автор: Sonya Bahar
Название: The Essential Tension
ISBN: 940241052X ISBN-13(EAN): 9789402410525
Издательство: Springer
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Цена: 8537.00 р.
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Описание: Part III addresses experimental studies of cooperation and competition, as well as controversial ideas such as the evolution of evolvability and Stephen Jay Gould`s suggestion that "spandrels" at one level of selection serve as possible sources of variability for the next higher level.

Автор: Lee E. Limbird
Название: Cell Surface Receptors: A Short Course on Theory and Methods
ISBN: 1461285356 ISBN-13(EAN): 9781461285359
Издательство: Springer
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Цена: 27931.00 р.
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Описание: Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors.

Автор: Cornelia Kasper; Frank Witte; Ralf P?rtner
Название: Tissue Engineering III: Cell - Surface Interactions for Tissue Culture
ISBN: 3642447279 ISBN-13(EAN): 9783642447273
Издательство: Springer
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Цена: 39895.00 р.
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Описание: Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues, by Margit Schulze and Edda Tobiasch. Microenvironment Design for Stem Cell Fate Determination, by Tali Re`em and Smadar Cohen. Stem Cell Differentiation Depending on Different Surfaces, by Sonja Kress, Anne Neumann, Birgit Weyand and Cornelia Kasper.