This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.
Автор: Banoub, Joseph H. Название: Mass Spectrometry of Nucleosides and Nucleic Acids ISBN: 1420044028 ISBN-13(EAN): 9781420044027 Издательство: Taylor&Francis Рейтинг: Цена: 30624.00 р. Наличие на складе: Нет в наличии.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642773583 ISBN-13(EAN): 9783642773587 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular biology is one of the most rapidly growingdeveloping and at the same time most exciting disciplines. Nucleic Acids in Molecular Biology keepsscientists informed of the explosively growing informationand complies with the great interest in this field byoffering a continued high standard of review.
Автор: Jack T. Trevors; J.Dick van Elsas Название: Nucleic Acids in the Environment ISBN: 3540580697 ISBN-13(EAN): 9783540580690 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular biological techniques such as DNA/RNA extraction and purification offer new opportunities for the determination of microbial cells from soils, roots, sediments and aquatic environments. This manual provides detailed protocols for these techniques in the environmental sciences.
Описание: The book will present the progress made since the last meeting in fall 2013 concerning the analysis of circulating extra-cellular nucleic acids. There are a modest number of laboratories involved in this field, nevertheless the number of papers published by researchers is extensive. The articles which will be published in this meeting report will be a valuable contribution for researchers and research students alike and will help them to stay on top of the developments in different research areas and to „cross borders“ between them.
Автор: Nakatani Kazuhiko, Tor Yitzhak Название: Modified Nucleic Acids ISBN: 3319800760 ISBN-13(EAN): 9783319800769 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Emissive 5-Substituted Uridine Analogues.- Fluorescent purine nucleosides and their applications.- Thiazole orange-tethered nucleic acids and ECHO probes for fluorometric detection of nucleic acids.- Synthetic wavelength-shifting fluorescent probes of nucleic acids.- DNA Assisted Multichromophore Assembly.- Polymerase Synthesis of Base-Modified DNA.- Photo-cross-linking Reaction in Nucleic Acids - Chemistry and Applications.- Site-Directed Spin Labeling for EPR Studies of Nucleic Acids.- Non-Covalent Modification of Double Stranded DNA at the Mismatch and Bulged Site.- 2',4'-Bridged Nucleic Acids for Targeting Double-Stranded DNA.- Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-oxoguanine.- Genetic alphabet expansion by unnatural base pair creation and its application to high affinity DNA aptamers.
Автор: Jurga Stefan, Erdmann (Deceased) Volker A., Barciszewski Jan Название: Modified Nucleic Acids in Biology and Medicine ISBN: 3319816934 ISBN-13(EAN): 9783319816937 Издательство: Springer Рейтинг: Цена: 21953.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642465986 ISBN-13(EAN): 9783642465987 Издательство: Springer Рейтинг: Цена: 12196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642779522 ISBN-13(EAN): 9783642779527 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular biology is one of the most rapidly growing develo-ping and at thesame time most exciting disciplines. Nucleic Acids and Molecular Biology keeps scientistsinformed of the explosively growing information and complieswith with the great interest in this field by offering acontinued high standard of review.
Автор: Keller Название: Nucleic Acids as Molecular Diagnostics ISBN: 3527335560 ISBN-13(EAN): 9783527335565 Издательство: Wiley Рейтинг: Цена: 14882.00 р. Наличие на складе: Поставка под заказ.
Автор: Martin, Dr Robin Название: Gel Electrophoresis: Nucleic Acids ISBN: 1872748287 ISBN-13(EAN): 9781872748283 Издательство: Taylor&Francis Рейтинг: Цена: 7501.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Fritz Eckstein Eckstein Название: Nucleic Acids and Molecular Biology ISBN: 3642794904 ISBN-13(EAN): 9783642794902 Издательство: Springer Рейтинг: Цена: 15855.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins.Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review.
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