Guide to Targeted Therapies: EGFR mutations in NSCLC, Federico Cappuzzo

Автор: Burstein, Harold
Название: Targeted therapies in breast cancer
ISBN: 0199735670 ISBN-13(EAN): 9780199735679
Издательство: Oxford Academ
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Цена: 2970.00 р. 4243.00 -30%
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Описание: This book provides clinicians with ultra-concise, evidence-based current information and insight on implementing the latest treatment strategies, for treating breast cancer, including targeted agents, into clinical practice.

Автор: Manfred Dietel
Название: Targeted Therapies in Cancer
ISBN: 3642432433 ISBN-13(EAN): 9783642432439
Издательство: Springer
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Цена: 20733.00 р.
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Описание: From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

Автор: Francesco Colotta; Alberto Mantovani
Название: Targeted Therapies in Cancer:
ISBN: 1441925376 ISBN-13(EAN): 9781441925374
Издательство: Springer
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Цена: 18237.00 р.
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Описание: This crucial text offers readers an overview of diverse approaches to targeted cancer therapies, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.

Автор: Daniel Gioeli
Название: Targeted Therapies
ISBN: 1617797448 ISBN-13(EAN): 9781617797446
Издательство: Springer
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Цена: 24394.00 р.
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Описание: Targeted Therapies highlights changes in the signaling network in response to inhibition of a signaling event. The text illustrates how a mechanistic understanding of the signaling network in cancer is important to developing targeted cancer therapies.

Автор: Amanda Tivnan
Название: Resistance to Targeted Therapies Against Adult Brain Cancers
ISBN: 331946504X ISBN-13(EAN): 9783319465043
Издательство: Springer
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Цена: 20516.00 р.
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Описание: This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Автор: Jenifer Prosperi
Название: Resistance to Targeted Therapies in Breast Cancer
ISBN: 331970141X ISBN-13(EAN): 9783319701417
Издательство: Springer
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Цена: 19514.00 р.
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Описание: We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling).

Автор: Antonio Russo; Rafael Rosell; Christian Rolfo
Название: Targeted Therapies for Solid Tumors
ISBN: 1493920464 ISBN-13(EAN): 9781493920464
Издательство: Springer
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Цена: 14635.00 р.
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Описание: Targeted Therapies for Solid Tumors

Автор: G. Obe
Название: Mutations in Man
ISBN: 3642695329 ISBN-13(EAN): 9783642695322
Издательство: Springer
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Цена: 13415.00 р.
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Описание: In no case has it been shown unequivocally that physical or chemical mutagens have led to an elevation of the mutation rate in the germ cells of man, but in view of the huge body of experi- mental data this seems to be a problem of detection.

Автор: Keshav K. Singh
Название: Mitochondrial DNA Mutations in Aging, Disease and Cancer
ISBN: 3662125110 ISBN-13(EAN): 9783662125113
Издательство: Springer
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Цена: 14818.00 р.
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Описание: Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson`s, Alzheimer`s, and Huntington`s diseases.